112- Wrist Trauma Flashcards

1
Q

What is the biochemical composition of tendons?

A

Water = 55% wet weight
Collagen = 80% dry weight
(95% type I)
Elastin <1% wet weight

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2
Q

What is the function of tendons?

A

Connect muscle - bone

Transmits force
Focuses pull
Acts as a pulley
Act as a spring
Holds tendons and joints together
High tensile strength
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3
Q

What is the structure of a tendon?

A

Long collagen spirals
Make up of tenocyte / fibroblast cells
Covered in sheaths (endotendon inside, epitendon on outside)
There is a hierarchical structure: fibron, fibre, subfasicle, fasicle, fibre bundle, tendon.

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4
Q

What is the enthesis?

A

The bone-tendon junction

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5
Q

What are the proterties at the enthesis?

A

Fibrocartillage band
More collagen like - more proteoglycans
Dissapates compressive forces

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6
Q

How do you differentiate between the insertion and the origin of a tendon attaching to bone?

A

Insertion - moves

Origin - doesn’t move, angle stays the same

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7
Q

What is the myotendunous junction? How is it specialised?

A

Muscle-tendon join

Also hierarchical - muscle and tendons have a continuous flow - increasing the anchoring.

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8
Q

What makes up ligaments?

A

Water - 60-70% wet weight
Collagen 70-80% dry weight
90% type I, 10% type II
Elastin <5%

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9
Q

What are ligaments?

A

Dense white fibrillar structures, have a passive stablising role in mechanical functions
- Supply proprioceptive function

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10
Q

What differences are there between ligaments and tendons?

A
Ligaments = more vascular
Ligaments = relatively acellular
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11
Q

What cells make up Ligaments?

A

Fibroblastic cells

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12
Q

What is an example of a modified ligament?

A

Articular disks

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13
Q

What is the effect of exercise on tendons and ligaments?

A

Tendons - Increase collagen fibril size, strenght and stiffness

Ligaments - Increase collagen content, number of fibrils and number of small fibrils

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14
Q

What is connective tissue?

A

ECM and support cells

eg. collagen, elastin, proteoglycans, glycoprotiens

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15
Q

Which collagen types are fibrillar?

A

I, II, III, V, XI

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16
Q

Which collagen types are fibril associated?

A

IX, XII…

17
Q

Which collagen types are sheet forming?

A

IV, VII, XV eg. basal lamina

18
Q

Which collagen types are transmembrane?

A

XIII XVII eg. adhesion receptors