1.1- what is cardiovascular disease ? Flashcards

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1
Q

what is a cardiovascular disease (CVDs) ?

A

a disease of the heart and circulation and are the main cause of death in the UK

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2
Q

what is an open circulatory system

A
  • when blood circulates in a large open system, normally in insects
  • the heart pumps blood into cavities surrounding the animals organs
  • substances can then diffuse between the blood and the cell
  • when the heart relaxes blood is drawn back into the cavities through valved openings along its length
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3
Q

what is a closed circulatory system

A
  • the blood is enclosed in blood vessels, in many animals and all vertebrates
  • generates higher blood pressures as blood is forced along the the blood vessels
  • means blood travels faster and so the blood system is more efficient
  • animals with closed circulatory systems are normally bigger and more active
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4
Q

The general path of blood by a closed system

A
  • blood leaves heart under pressure and flows along arteries and then arterioles to capillaries
  • there are lots of capillaries which come into close contact with most of the cells in the body where substances are exchanged
  • then blood returns to the heart by venules and then veins
  • valves make sure the blood flows in only one direction
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5
Q

path of blood in a single circulatory system

A
  • fish used as an example
  • heart pumps blood to the gills
  • gaseous exchange takes place; there is diffusion of CO2 from the blood into the water that surrounds the gills and then diffusion of oxygen from water to the gills
  • the blood leaves the gills and then flows around the rest of the body before returning to the heart
  • they have one ventricle and one atrium
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6
Q

what is a double circulatory system

A
  • birds and mammals have one
  • the right ventricle pumps de-oxygenated blood to the lungs where it receives oxygen
  • oxygenated blood then returns to the heart to be pumped a second time by the left ventricle out to the rest of the body
  • the blood gets an extra boost that reduces time taken for blood to circulate to the rest of the body
  • therefore birds and mammals have a high metabolic rate
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7
Q

why do many animals need a circulatory system

A
  • in multicellular organisms they are too large for substances to diffuse and move around their body quick enough unlike uni-cellular organisms that are small enough for diffusion to be adequate
  • they have to rely on a mass transport system to move substances efficiently by mass flow- a circulatory system
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8
Q

what is mass flow

A

The transport medium in animals is blood, mass flow means that blood is transported in one direction due to a difference in pressure

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9
Q

what does it mean when water is described as having a dipole nature

A
  • has an unevenly distributed electrical charge
  • hydrogen end is slightly positive and oxygen end slightly negative
  • the slightly positive end is attracted to the slightly negative end of other water molecules
  • hydrogen bonding holds water molecules together
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10
Q

what are the properties of water that make it an ideal transport medium

A

Solvent-

  • many chemicals dissolve easily in water
  • allows vital biochemical reactions to occur as the chemicals are free to move around in the aqueous environment
  • dissolved substances can be transported around organisms
  • ionic and polar substances can dissolve easily as they get surrounded by water due to its dipole nature

Thermal properties-

  • specific heat capacity of water very high
  • large amount of energy required to break hydrogen bonds
  • water warms up and cools down slowly
  • helps organisms to avoid rapid changes in internal temp
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11
Q

Basic heart structure

A
  • made of carciac muscle
  • right side receives deoxygenated from body and pumps to lungs
  • left side receives oxygenated from lungs and pumps to body
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12
Q

what are the similarities between arteries and veins

A
  • walls of both vessels contain collagen to make them strong and durable
  • contain elastic fibres to allow stretch and recoil
  • smooth muscle cells in walls allows to constrict and dialate
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13
Q

differences between veins and arteries

A
  • arteries narrow lumen- veins wide lumen
  • arteries thicker walls- veins thinner walls
  • arteries more collagen,smooth muscle and elastic fibres- veins less
  • arteries have no valves- veins do
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14
Q

how does blood move through the vessels

A
  • during systole blood is forced into arteries and walls stretch to accommodate
  • during diastole elasticity of artery walls causes them to recoil behind blood, pushing blood forward and smoothing blood flow
  • when blood reaches capillaries blood flow is steady
  • blood flows slower in capillaries as smaller lumen and friction from walls
  • allows for exchange
  • blood flows steady through veins- no pulses
  • assisted by contraction of nearby muscles
  • backflow prevented in veins due to semi lunar
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15
Q

what happens during atrial systole

A
  • blood returns to heart due to action of skeletal muscles and breathing
  • blood under low pressure into left and right atria from pulmonary veins and vena cava
  • as they fill increased pressure forces tricuspid and bicuspid valve open and leaks into ventricles
  • atria then contract to push blood into ventricles
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16
Q

what happens during ventricular systole

A
  • they contract forcing open semilunar valves
  • pushes blood through pulmonary arteries an aorta
  • pressure against atrio ventricular valves keeps them closed
17
Q

what happens during cardiac diastole

A
  • atria and ventricles relax
  • elastic recoil reduces heart pressure
  • blood under high pressure in aorta an pulmonary arteries is drawn back towards ventricles closing the semi lunar valves
  • coronary arteries fill during diastole
  • low pressure helps draw blood from pulmonary veins
18
Q

what is atherosclerosis (AT)

A
  • disease process that leads to coronary heart disease and strokes
  • fatty deposits can either block artery directly or make it more likely to be blocked by thrombosis
  • if coronary arteries complete block causes heart attack or in brain causes stroke
19
Q

what is the endothelium in an artery

A
  • endothelium is delicate layer of cells that lines inside of artery and separates blood flow from muscular wall
20
Q

what happens in AT

A
  • endothelium is damaged or becomes dysfunctional
  • then an inflammatory response
  • white blood cells leave blood vessel and move to artery wall
  • these cells accumulate chemicals from blood, mainly cholesterol which is deposited, called an atheroma
  • calcium salts and fibrous tissue also build up, resulting in hard swelling called a plaque on inner wall of artery
  • build up means artery loses some elasticity
  • plaque narrows artery lumen so more difficult for blood to flow and can lead to rise in blood pressure- positive feedback as the increase makes more plaques more common and cycle continues
21
Q

why does blood clot in arteries

A
  • vital when blood vessel damaged to seal the break- limits blood loss and prevents entry of pathogens
22
Q

what happens during the clotting cascade

A
  • platelets and damaged tissue release protein thromboplastin
  • that activates an enzyme that catalyses conversion of prothrombin to enzyme called thrombin
  • thrombin catalyses conversion of soluble protein fibrinogen to insoluble fibrin
  • mesh of fibrin forms that traps more platelets and red blood cells to form clot