11. Vestibular system Flashcards
Which 3 systems maintain balance?
- Proprioception
- Vision
- Inner ear
What is the only thing the balance system can detect?
• Only acceleration
- angle acceleration (turning)
- linear acceleration (forward/backward)
What is angular acceleration governed by?
3 semi-circular canals (head motion)
What is linear acceleration governed by?
2 otolith organs
What are the normal functions of the vestibular system?
- Subserve perception of movement in space and tilt with respect to gravity
- Provide reflex balance reactions to sudden instability of gait or posture (vestibulo-spinal reflexes)
- Stabilise the eyes on earth fixed targets - preserving visual acuity during head movements (vestibulo-ocular reflexes)
- Assist control of blood pressure and heart rate during rapid up-down tilts
- Assist synchronisation of respiration with body reorientations
- Provokes motion sickness
- Provide a reference of absolute motion in space - spatial orientation
What is the disorder relating to a false perception of movement in space?
Vertigo
vestibulo-cortical
What is the disorder relating to instability of gait and posture?
Vestibular ataxia
vestibulo-spinal
What are the 2 disorders relating to the inability to stabilise the eyes?
- Vestibular nystagmus - unilateral lesions
- Oscillopsia - during head movement in bilateral vestibular lesions
(vestibulo-ocular)
What problems can arise in the acute phase of vestibular loss, and unilateral vestibular loss, respectively?
- Slight impairment of orthostatic control
* Severe nausea and vomiting
What can a disorder of the vestibular system lead to, relating to orientation and motion?
Loss of co-ordination on:
• directional reorientation
• motion intolerance
• oversensitivity to visual motion in the environment
Which vestibular projection is related to nausea?
Vestibulo-autonomic
What are the 2 main parts of the vestibular labyrinth?
• Bony labyrinth - bounded by petrous temporal bone filled with perilymph
• Membranous labyrinth
- filled with endolymph containing the receptor cells
- located within the utricle, saccule and semicircular canals
Where are the epithelial hair cells (sensory receptors) located in the vestibular labyrinth?
- Macula - utricle and saccule
* Crista ampullaris (swelling of semicircular canals)
Where are the primary afferent neurones located in relation to the vestibular labyrinth?
- Cell bodies in vestibular ganglion
- Peripheral processes end in macula and ampulla
- Central process synapse in brainstem vestibular nuclei
What causes the deflection of the hair cells in the canals and which nerve do they signal to?
- Head movement
- Acceleration causes endolymph movement => deflection of macula (where all the hair cells are)
- When you stop, this occurs in the opposite direction
- Signals to the auditory nerve (cochlear nerve - one of 2 parts of CN VIII)
What are hair cell cilia embedded in?
- Otoconia
* Gelatinous matrix containing calcium carbonate crystals
How are the sensory hair cilia arranged?
- Stereocilia - arranged in rows of varying heights
* Kinocilium - tallest one, for morphogenesis and mechotransduction
What are the different nerve endings on hair cells?
- Type I - chalice-like endings forming ribbon synapses
* Type II - simple nerve terminals
Describe the transduction mechanisms of the hair cells (hair cell receptor potential + ganglion cell discharge)
Hair cell receptor potential
• towards the kinocilium = depolarisation
• away from the kinocilium => hyperpolarisation
Ganglion cell discharge
• towards to kinocilium => increased frequency
• away from the kinocilium => decreased frequency
What is the striola?
- Dividing ridge that runs through the middle of the macula
- Divides hair cells into populations with opposing hair bundle polarities
- Kinocilia are oriented towards from it in the utricle, and away from it in the saccule
- Tilt of the head to one side has opposite effects on corresponding hair cells of the other side
Describe the orientation of the Otolith organs
Saccule
• Approximately vertical plane
• Hair cells with their overlaying layer of otoconia project normal to the plane with directional sensitivities:
- all combinations of vertical and antero-posterior directions
Utricle
• Approximately horizontal plane
• Hair cells project vertically with directional sensitivities:
- all combinations of lateral and antero-posterior directions