11 Mycology Flashcards

1
Q

What are the characteristics of fungi?

A
Microscopic
Eukaryotic
Possess a nucleus
Have several chromosomes
DO NOT all look the same (different shapes and structures)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which fungi are most important medically?

A

Yeasts or filamentous fungi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Are fungi harmful?

A

Some can be, eg produce contaminants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are fungi a source of?

A

Antibiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the fungi cell wall made from?

A

Polysaccharide mainly β-glucan with mannan and chitin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What temperature do most medically important fungi grow optimally at?

A

Around 20-25°C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Where do most fungi tend to exist?

A

Outside the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What does the growth of fungi include?

A

Vegetative growth and spore formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

In what conditions will vegetative growth occur?

A

During times of access to a rich supply of nutrients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

In what conditions will sporulation used?

A

Used as a strategy to allow an organism to persist under harsh conditions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Does fungal growth involve sexual or asexual reproduction?

A

Both

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the properties of yeast?

A

Unicellular, spherical fungi
Typical diameter around 10um
Facultative anaerobes (can live with or without anaerobes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How do yeasts replicate asexually?

A

Some undergo binary fission (two identical daughter cells)

Some use budding (small daughter cell buds off from parent cell)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is Saccharomyces cervisiae used in?

A

Bread making and brewing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Where is Candida albicans found?

A

Intestinal tract, mouth and vagina

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do filamentous fungi look like and why?

A

Typically have a hairy appearance. Due to the hyphal growth of filamentous structures

17
Q

How long can hyphae grow and what does this result in?

A

Can grow to several cm in length which results in an elaborative and extensive branched formation

18
Q

What is the complex mass that hyphae produce called?

A

The mycelium

19
Q

What are the 3 groups of mycosis?

A

Superficial
Cutaneous and subcutaneous
Deep

20
Q

What are superficial infections and give a few examples

A

Affect the surface skin layer
Eg candidas
Eg tinea (ringworm)

21
Q

Describe cutaneous and subcutaneous infections

A

Beneath or within structures like skin, nails and hair

22
Q

Describe a deep infection.

A

Causes infection within the body eg aspergillosis (farmers lung)

23
Q

Are fungal infections fatal?

A

Unlikely to be fatal but highly unpleasant.

Could possibly be fatal in immunocomprimised patients

24
Q

Are antibacterial agent effective against fungi?

25
Are anti-eukaryotic compounds safe to use? Explain answer.
No because they could effect the patient
26
What are the differences between the membrane composition in human and fungal cells?
Cholesterol is found in mammals. Ergosterol is a derivative of cholesterol and is found in fungi - fungi need it to survive
27
How can the biosynthesis of ergosterol be restricted?
By blocking steps in the pathway which would inhibit the reaction carried out by the enzymes
28
What are the two cellular features which can be used to identify antifungals?
Cell wall | Cell membrane
29
What are the names of the 4 main antifungal agents used
Polyenes Azoles Allylamines Echinocandins
30
What are the chemical properties of polyene antifungals?
Poly-unsaturated organic molecules with 3 or more alternating C=C and C-C bonds Large macrolide lactone ring Several hydroxyl groups
31
What are polyene antifungals active against?
Fungal pathogens
32
What can prolonged use of polyene antifungals do?
Prolonged use can pose renal problems - reserved for serious systemic infections