11. GI1 Clinical Case Correlations (Dr. McGowan) Flashcards

1
Q

What does a “bird beak appearance” on barium swallow indicate?

A

Primary achalasia

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2
Q

What is the drawback to magnetic resonance cholangiopancreatography “MRCP?”

A

While it is less invasive than endoscopic retrograde cholangiopancreatography, it does not have the potential for therapeutic benefit – e.g. biopsy, stents, injection of dye, etc.

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3
Q

How might we diagnose pancreatitis from a lab?

A

Lipase and amylase levels in the blood.

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4
Q

What is emphysematous cholecystitis?

A

An infection of the gallbladder wall by gas forming organisms.

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5
Q

What are the four signs given for gastrointestinal bleeding?

A

“Coffee grounds” emesis, hematemesis, melena, or hematochezia.

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6
Q

What should we be thinking of diagnostically if we see free air on a plain film x-ray?

A

A perforated hollow organ pushing air into the space.

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7
Q

NSAID use is a risk factor for what common disease discussed in this lecture?

A

Gastric ulcer.

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8
Q

What do most people consider the liver function tests?

A

ALT/AST

Alkaline phosphatase (ALP)

Bilirubin

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9
Q

Esophagogastroduodenoscopy is contraindicated in patients with what upper G.I. symptoms?

Why?

A

Halitosis, difficulty swallowing, or (uncommonly) a palpable mass in the upper esophagus.

These are symptoms of Zenker diverticulum, which can result in a perforation if an esophagogastroduodenoscopy is performed.

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10
Q

What are the two best, first-line tests for Helicobacter pylori?

What do you need to make sure that your patient does before you do these tests?

A

Urea breath test, fecal antigen test.

Patients must stop all proton pump inhibitor use for two weeks before either test is performed.

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11
Q

What causes primary achalasia?

A

Loss of nitric oxide inhibitory neurons in the myenteric plexus of the lower esophageal sphincter, causing it to be unable to relax.

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12
Q

Which takes longer to develop symptoms, gastric ulcer or duodenal ulcer?

A

Duodenal ulcers take 3 to 5 hours after eating to develop pain.

In contrast, gastric ulcers only take 30 minutes to 90 minutes.

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13
Q

What does HIDA (hydroxy iminodiacetic acid scan) test for?

A

Gallbladder obstruction. It is a nuclear study using hydroxy iminodiacetic acid, and if the gallbladder is obstructed the gallbladder will not be visible due to an inability of the contrast to enter the gallbladder.

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14
Q

What is the gold standard test for achalasia?

A

Manometry.

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15
Q

What is Romaña’s sign and what does it indicate?

A

Romaña’s sign is unilateral orbital edema, caused by Chagas Disease (Trypanosoma cruzi infection.)

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16
Q

What is a common complication of endoscopic retrograde cholangiopancreatography ““ERCP”?

A

Pancreatitis – due to the fact that a wire is being passed through the sphincter of Oddi into the pancreatic duct.

17
Q

What special test is often performed for suspected Zollinger-Ellison syndrome?

A

Secretin stimulation test.

Secretin should inhibit gastrin production, however in Zollinger-Ellison syndrome secretin paradoxically stimulates gastrin production.

18
Q

Is primary achalasia sudden or progressive?

A

Progressive and gradual.

19
Q

What are Cushing ulcers and Curling ulcers?

A

Cushing ulcers are secondary to an intracranial lesion or injury.

Curling ulcers are secondary to severe burns.

20
Q

What are the types of pain associated with a gastric ulcer vs. a duodenal ulcer?

A

Gastric ulcers are described as sharp and burning.

Duodenal ulcers are described as gnawing.

21
Q

Smoking tobacco and drinking alcohol are synergistic risk factors for what G.I. related cancer?

A

Squamous cell carcinoma of the esophagus.

22
Q

What disease might you expect if you have a serum gastrin level of greater than 1000 ng/L?

A

Zollinger-Ellison gastrinoma

23
Q

What two cancers are associated with Helicobacter pylori infection?

A

Gastric adenocarcinoma.

Gastric mucosa associated lymphoid tissue (MALT) lymphoma.

24
Q

What strain of Helicobacter pylori significantly increases risk of ulcer?

A

Cag-A toxin positive Helicobacter pylori.