11 - Factors Affecting Drug Activity Flashcards
this occurs when two drugs with similar pharmacological actions are taken (alcohol + sedative = increased drowsiness)
additive effect
an abnormal sensitivity generally resulting in an allergic reaction
hypersensitivity
a potentially fatal hypersensitivity reaction that produces severe respiratory distress and cardiovascular collapse
anaphylactic shock
the ability of a substance to harm the kidneys
nephrotoxicity
when one drug with no inherent activity of its own increases the activity of another drug, producing an effect
potentiation
when one drug is moved from protein binding sites by a second drug, resulting in increased effects of the displaced drug
displacement
when two different molecules associate or attach o each other
complexation
a chronic and potentially fatal liver disease causing loss of function and resistance to blood flow through the liver
cirrhosis
a chronic and potentially fatal liver disease causing loss of function and resistance to blood flow through the liver
cirrhosis
when two drugs with with similar pharmaceutical actions produce an effect equal to the sim of their individual effects
synergism
when two drugs with with similar pharmaceutical actions produce an effect equal to the sim of their individual effects
synergism
this endogenous compound is used to monitor renal function
creatinine
what hepatic function decreases by a hepatic disease
first-pass metabolism
when the body creates this, hypersensitivity can happen
antibodies