11 - Factors Affecting Drug Activity Flashcards

1
Q

this occurs when two drugs with similar pharmacological actions are taken (alcohol + sedative = increased drowsiness)

A

additive effect

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2
Q

an abnormal sensitivity generally resulting in an allergic reaction

A

hypersensitivity

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3
Q

a potentially fatal hypersensitivity reaction that produces severe respiratory distress and cardiovascular collapse

A

anaphylactic shock

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4
Q

the ability of a substance to harm the kidneys

A

nephrotoxicity

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5
Q

when one drug with no inherent activity of its own increases the activity of another drug, producing an effect

A

potentiation

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6
Q

when one drug is moved from protein binding sites by a second drug, resulting in increased effects of the displaced drug

A

displacement

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7
Q

when two different molecules associate or attach o each other

A

complexation

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8
Q

a chronic and potentially fatal liver disease causing loss of function and resistance to blood flow through the liver

A

cirrhosis

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9
Q

a chronic and potentially fatal liver disease causing loss of function and resistance to blood flow through the liver

A

cirrhosis

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10
Q

when two drugs with with similar pharmaceutical actions produce an effect equal to the sim of their individual effects

A

synergism

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11
Q

when two drugs with with similar pharmaceutical actions produce an effect equal to the sim of their individual effects

A

synergism

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12
Q

this endogenous compound is used to monitor renal function

A

creatinine

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13
Q

what hepatic function decreases by a hepatic disease

A

first-pass metabolism

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14
Q

when the body creates this, hypersensitivity can happen

A

antibodies

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