10 - Basic Biopharmeceutics Flashcards
the bioavailability a drug product compared to the same drug in rapidly administered IV solution
absolute bioavailability
the blood filtering process of the nephron
glomerular filtration
drugs that activate receptors to accelerate or slow normal cellular function
agonists
the time a drug will stay in the stomach before it is emptied into the the small intestine
gastric emptying time
drugs that bind with receptors but do not activate them
antagonists
the amount of an administered dose that reaches the general circulation and the rate at which this occurs
bioavailability
the substantial degradation of an orally administered drug caused by enzyme metabolism in the liver before the drug reaches the systemic circulation
first-pass metabolism
when different molecules associate or attach to each other
complexation
the rime the drug concentration is above the MEC
duration of action
the transfer of drugs and their metabolites from the liver to the bile and the gall bladder, then into the intestine, and then back into circulation
enterohepatic cycling
a complex protein that catalyzes chemical reactions
enzyme
the blood concentration needed for a drug to produce a response
minimum effective concentration (MEC)
the blood concentration needed for a drug to produce a response
minimum effective concentration (MEC)
a drug’s blood concentration range between it’s MEC and MTC
therapeutic window
a drug’s blood concentration range between it’s MEC and MTC
therapeutic window
drug products that contain the same active ingredient but no necessarily in the same salt form, amount, or dosage form
pharmaceutical alternative
the bioavailability of a drug product compared to the same drug in any other dosage form than a rapidly administered IV solution
relative bioavailability
the bioavailability of a drug product compared to the same drug in any other dosage form than a rapidly administered IV solution
relative bioavailability
the substance resulting from the body’s transformation of an administered drug
metabolites
the time MEC is reached and the response occurs
onset of action
the attachment of a drug molecule to a protein, effectively making the drug inactive
protein binding
the minimum amount of a drug’s blood concentration to have potentially harmful affects to the patient
minimum toxic concentration (MTC)
the minimum amount of a drug’s blood concentration to have potentially harmful affects to the patient
minimum toxic concentration (MTC)
the amount of times a drugs half-life must have elapsed for the elimination of a drug to be essentially complete
five times
