1.06 - Gram Positive Rods and Gram Negative Cocci Flashcards

1
Q

What is the antiphagocytic feature of Bacillus anthracis encoded by the PXO2 plasmid

A

poly-D-glutamic acid capsule

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2
Q

The exotoxin property of B. anthracis is encoded by the ___ plasmid

A

PXO1 plasmid

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3
Q

The edema toxin of B. anthracis functions by ___

A

inhibiting neutorphil function and elevating intracellular cAMP, therefore causing local edema

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4
Q

The edema toxin is a combination of ___

A

Protective Antigen (PA) and Edema Factor (EF) of B. anthracis

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5
Q

Cuttaneous anthrax starts as ___

A

painless dark pustule

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6
Q

Pulmonary anthrax is also known as

A

Wool sorter’s disease

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7
Q

Wool sorter’s disease is caused by (mode of transmission)

A

inhalation of spores of those who handle raw wool, hides or horse hair

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8
Q

The __ test uses a medium containing penicillin to diagnose and differentiate B. anthraces from B. cereus

A

Strings of Pearls Test

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9
Q

B. anthracis is gamma phage (positive or negative)

A

Gamma phage positive

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10
Q

What is the causative agent in the Chinese Restaurant Syndrome

A

B. cereus

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11
Q

on BAP, B. anthracis produces colonies that look ____

A

large, raised, opaque, grayish white colonies with media heads and ground glass appearance

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12
Q

B. cereus is resistant to ___

A

Cephalosporin

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13
Q

The virulence factor of B. cereus is the __

A

Glucoprotein S layer which promotes adherence and interaction with PMNs

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14
Q

Clinical manifestations of B. cereus

A

Opthalmitis

Gastroenteritis which may be emetic or diarrheal form

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15
Q

Treatment for B. cereus

A

Vancomycin, clindamycin, gentamycin

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16
Q

Morphology of corynebacterium diptheria

A

Chinese letter arrangement
Club-shaped swelling at one or both ends
Metachromatic granules

17
Q

The important virulence factor of corynebacterium diphtheria is the ___ which ___ (state action of virulence factor)

A

Exotoxin which has lysogenic property

inhibits protein synthesis and EF2, lysogenic property

18
Q

Mode of transmission of corynebacterium diptheriea

A

Droplets from throat through coughing and sneezing

19
Q

Clinical manifestations of corynebacterium diptheria

A

Cutaneous - ulcer via punctured owund

Respiratory - colonize tonsils, nasal cavity and throat; pseudomembrane; bull neck appearance due to swollen lymph nodes

20
Q

Lab diagnosis for corynebacterium diptheria

A

Loeffler’s slant
potassium tellurite plate
Elek’s toxigenicity test

21
Q

Treatment of diptheria

A

antitoxin AND antibiotic (penicillin)

22
Q

Listeria monocytogenes inhabits the __

A

GI and female genitourinary tract

23
Q

This is the only gram-positive that has an endotoxin

A

Listeria monocytogenes

24
Q

Virulence factor of listeria monocytogenes which acts as a hemolysin to escape from phagosome

A

LLO (Listeriolysin O)

25
Q

Food product commonly affected by listeria monocytogenes

A

Dairy products, unpasteurized milk, and ground meat

26
Q

Treatment and prevention of listeria monocytogenes

A

Ampicillin, vancomycin, ciprofloxacin

27
Q

most important clinical manifestation of erysipelothrix rhusipathiae

A

erysipelas in swine

Erysipeloud nodular cellulitis in humans

28
Q

People at great risk for erysipelothrix rhusipathiae are___

A

fishermen, fish handlers, abattoir workers, butchers

29
Q

What medium favors the growth of neisseria species

A

Thayer-Martin medium

30
Q

Biochemical properties of neisseria meningitidis

A

catalase (+)
oxidase (+)
maltose and glucose fermenter

31
Q

Treatment of neisseria menigitidis

A

Penicillin G

3rd gen cepahlosporin *ceftriaxone, cefotaxime

32
Q

Prophylaxis for n. menigitidis

A

Rifampin and ciprofloxacin