10. Q and A session

Question 1

The nicotinic acetylcholine receptor is an example of
- G-protein coupled receptor
- tyrosine kinase receptor
- ligand gated ion channel
- voltage gated ion channel

Answer 1

C

Question 3

Glucuronidation …
- decreases a drugs water solubility
- increases a drugs pharmacological activity
- is an example of phase 1 metabolism
- is saturated in paracetamol overdose
- involves cytochrome p450s

Answer 3

D

Question 4

A drug given as a 100mg single IV dose, results in peak plasma concentration of 20 ug/ml. the apparent volume of distribution is …
- 0.5l
- 1l
- 2l
- 5l
- 10l

Answer 4

D

Question 5

The intravenous route of administration is used a drugs …
- which are highly bound to plasma proteins
- which may be easily altered in acidic pH of stomach
- with a short half life
- with a small volume of distribution
- to increase their pharmacological activity

Answer 5

B

Question 6

When the drug is in stomach acid, it will pass through stomach walls best if it is …
- alkaline
- acidic
- neutral

Answer 6

B

Question 7

Drug transport across the GI tract is not affected by …
- drug formation
- drug pKa
- gastric motility
- pH of gastric fluid
- phase II metabolism

Answer 7

E