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Question 1

Main pathway for production of NADPH

Answer 1

PPP

Question 2

Iodoacetate

Answer 2

Non-specific inhibitor for Glyceraldehyde-3-P DH

Question 3

PFK-1 inhibitors

Answer 3

ATP, Citrate

Question 4

PFK-1 Activators

Answer 4

AMP, ADP, F-2,6-BisP

Question 5

MCAD Deficiency

Answer 5

Medium-chain Acyl-CoA Dehydrogenase Deficiency
- most common inborn error of ß-oxidation
- can’t oxidize 6-10C FA’s
- severe hypoglycemia and hypoketonemia
- treated by avoiding fasting

Question 6

Diabetic Ketoacidosis

Answer 6

In uncontrolled DM type I, no insulin is produced (autoimmune disease, destroys insulin producing cells). This results in up regulation of lipolysis, and up regulation of ketone body production. Too many ketone bodies in the blood causes acidosis, or acidic blood.

Question 7

Ketogenesis vs Cholesterol Synthesis

Answer 7

Both produce HMG CoA, but Ketogenesis is located in the mitochondria, while CH synthesis is located in the ER. They also vary based on conditions of the cell _____

Question 8

Can the liver use ketone bodies?

Answer 8

No, it lacks the thiolase enzyme (it uses thiophorase)