10/22 Thiamine Deficiency

Question 1

storage capacity of B1

Answer 1

18 days

Question 2

how to measure B1 levels

Answer 2

blood sample, RBC transketolase requires TPP

add TPP or dont, if enzymze activity does not increase, no deficiency

Question 3

active form of thiamine

Answer 3

Thiamine pyrophosphate

TPP

Question 4

products of dehydration rxns utilizing TPP

Answer 4

CO2, NADH, R-CoA

Question 5

four enzymes that require TPP

Answer 5

pyruvate dehydrogenase
a-ketoglutarate dehydrogenase
branched chaing keto acid dehydrogenase
transketolast

Question 6

where does TPP get the PP

Answer 6

ATP

Question 7

negative regulators of pyruvate dehydrogenase

Answer 7

Acetyl-CoA

NADH

Question 8

foods rich in B1

Answer 8

dairy
meat (esp pork)
grains and legumes
fruits/vegs

Question 9

what lifestyle habit prevents uptake of B1

Answer 9

alcohol prevents enterocytes from taking up thiamine

Question 10

who is a B1 supplement indicated for

Answer 10

alcoholics
pregnant women
low cal diets
65+
eating disorders
elevated metabolism due to infection, inflammation, cancer, trauma

Question 11

Wernicke Cardiomyopathy

Answer 11

Beri Beri/B1 deficiency
cardiomegaly
SOB
fatigue
in alcoholics: peripheral neuropathy, low reflexes, parasthesia, E deficiency

Question 12

Tx for wernicke cardiomyopathy

Answer 12

glucose AND B1

Question 13

wernicke encephalopathy

Answer 13

caused by giving ONLY glucose to a B1 deficient pt in a hospital withouth B1
pt will become agitated, confused, ataxic

Question 14

wernicke-korsakoff

Answer 14

non-reversible
encephalopahy
impaired memory
Often given a coma cocktain in ED before cause is known

Question 15

what is a coma cocktail

Answer 15

B1, glucose, naloxone