10/13 Blood Glucose Flashcards
jamaican vomiting sickness
akee fruit (and lychee seeds) FA oxidation poison Hypoglycin A
time/condition: fed state
just ate
time/condition: post-parandial state
2-3 hours
digestion/absorption
time/condition: post-absorptive state
6-8 hours
insulin low, glucagon high
time/condition: basal state/early fasting
12 hours
glycogen running low, ketone mobilzation
time/condition: fasting state
24-72 hours
out of glycogen, increase in gluconeogenesis, increase in ketone production
time/condition: starved state/late fasting
> 72 hours
ketones are major source of E for brain
E: fed/fasting, RBCs
fed: glucose –> lactate
fasting: glucose –> lactate
E: fed/fasting, liver
fed: storage of glucose as glycogen, glycolysis, production of vLDLs
fasting: glycogenolysis, FA –> ketone production, FA –> ATP, glycerol –> glucose
E: fed/fasting, peripheral tissues
fed: AAs —> TCA cycle, AAs —> synthesis
fasting: protein breakdown to release AAs for E
E: fed/fasting, adipocytes
fed: storage of glucose/FAs/glycerol as TGs
fasting: FA oxidation
E: fed/fasting, muscle
fed: glycolysis, storage of glucose as glycogen
fasting: FA –> TCA cycle
E: fed/fasting, brain
fed: glycolysis
fasting: ketones –> TCA cycle (very little use of glucose for TCA cycle)
blood glucose maintainance in fed state
dietary carbs are source of glucose
excess is converted to glycogen by liver
blood glucose maintainance in fasted state
2-3 hours post parandial)
in liver, lactate/AAs/glycerol/glycogen contribute to blood glucose
