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D2 Summer - Growth & Development Final > 1 - Tooth Development > Flashcards

1 - Tooth Development Flashcards

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1
Q

When is the 1st sign of tooth development?

A

6-7 weeks in utero

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2
Q

Deciduous teeth begin to calcify when?

A

13-20 weeks in utero

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3
Q

When have all deciduous teeth begin to calcify?

A

18-20 weeks in utero

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4
Q

Deciduous teeth erupt when?

A

6-30 months

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5
Q

What is the 1st part of the tooth to calcify?

A

Crown

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6
Q

What are the stages of tooth development?

A
  1. Crown formation
  2. Root formation
  3. Supporting structure formation
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7
Q

What arch is where the majority of teeth originate from?

A

1st arch

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8
Q

Teeth are particular from what process?

A

Medial-nasal process

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9
Q

The primary epithelial band corresponds to what?

A

Future dental arches

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10
Q

This is a horseshoe shaped band that corresponds to future dental arches

A

Primary epithelial band

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11
Q

The primary epithelial band gives rise to what?

A
  1. Dental lamina
  2. Vestibular lamina
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12
Q

What is expressed where the tooth bud will form?

A

Shh → epithelia
Pax9 → mesenchyme

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13
Q

The neural crest mesenchyme induces _____ to become the dental lamina

A

Oral ectoderm

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14
Q

What are the stages of crown formation?

A

Initiation → bud stage → cap stage → bell stage → enamel/dentin/pulp

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15
Q

In what stage do epithelial cells show no major changes?

A

Bud stage

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16
Q

What hormones are involved in placode formation (ectoderm thickening)?

A

Shh, Lef-1, Eda-Edar

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17
Q

Shh, Lef-1, Eda-Edar are in what stage?

A

Bud stage

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18
Q

The enamel organ and dental papilla are formed in what stage?

A

Cap stage

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19
Q

Do we see epithelial growth in the Cap stage?

A

Yes

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20
Q

In what stage do we see the tooth germ?

A

Cap stage

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21
Q

What does the tooth germ consist of?

A
  1. Enamel organ
  2. Dental papilla
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22
Q

What are the outer and inner parts of the dental papilla?

A

Outer = dentin
Inner = pulp

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23
Q

In what stage do we see Enamel knot formation?

A

Cap stage

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24
Q

This is a key signaling center that consists of a cluster of non-dividing cells determines cusp formation?

A

Enamel knot

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25
Q

What does the enamel knot determine?

A

Cusp formation

26
Q

This is the enamel of the tooth

A

Enamel organ

27
Q

Cells in the enamel organ synthesize what into the ECM?

A

Glycosaminoglycans

28
Q

In what stage do we see glycosaminoglycans?

A

Cap stage

29
Q

What synthesize glycosaminoglycans?

A

Cells of the enamel organ (IEE & OEE)

30
Q

What do glycosaminoglycans do?

A

Hydrophilic and pull water into the enamel organ

31
Q

You get stellate reticulum formation by what and in what stage?

A

Glycosaminoglycans pulling water in
Cap stage

32
Q

What do glycosaminoglycans form?

A

Stellate reticulum cells

33
Q

In what stage does the stratum intermedium form?

A

Bell stage

34
Q

What stage does the crown attain full size and shape?

A

early Bell stage

35
Q

Permanent detention forms _____ to the deciduous dentition

A

Lingual

36
Q

The IEE and OEE are found in what stage?

A

Bell stage and cap

37
Q

These will differentiate into ameloblasts

A

IEE

38
Q

What will make odontoblasts and ameloblasts?

A

IEE

39
Q

The site of what determines future cusp formation?

A

IEE differentiates

40
Q

The junction of the IEE and OEE is called the

A

Cervical loop

41
Q

This is the future site of the CEJ

A

Cervical loop

42
Q

Dental papilla will form what?

A

Dentin
Pulp

43
Q

Dental follicles will form what?

A

Cementum
Periodontium

44
Q

In what stage do you see Tome’s process?

A

Secretory stage Amelogenesis

45
Q

What breaks and then separates the tooth from oral epithelium?

A

Dental lamina

46
Q

What proteins are associated with the secretory stage ameloblasts?

A

Amelogenin
Ameloblastin
Enamelin

47
Q

What are the proteases in secretory stage ameloblasts?

A

Enamelysin
Kallikrein

48
Q

In the secretory stage ameloblasts, what do they form?

A

Enamel rods and Inter-rod

49
Q

This is the 1st layer of dentin formed

A

Mantle dentin

50
Q

What are the characteristics of Mantle dentin?

A
  1. 1st formed
  2. Hypomineralized
  3. Only in the crown of the tooth
51
Q

This is formed during tooth development at 4um/day

A

Primary dentin

52
Q

This dentin is formed after tooth eruption

A

Secondary dentin

53
Q

This dentin is produced in response to injury to protect the pulp

A

Tertiary dentin

54
Q

IEE and OEE from the cervical loop proliferate downwards to form what?

A

Hertwig’s root sheath

55
Q

What happened to HERS before cementum?

A

Most of it is removed before cementum is laid down

56
Q

The hertwig’s root sheath is also the site of what?

A

CEJ

57
Q

Differentiation of cementoblasts are from what?

A

HERS
Dental follicle cells

58
Q

Remnants of hertwig’s are called

A

Epithelial rests of Malassez

59
Q

What are the kinds of Cementum?

A

Acellular = line the root
Cellular = bottom of the root

60
Q

What are the periodontal ligament fibers?

A
  1. Transseptal ligament
  2. Alveolar crest group
  3. Horizontal group
  4. Oblique group
  5. Apical group
  6. Interradicular group

D2 Summer - Growth & Development Final (11 decks)

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