1 The Principles of Prescribing Flashcards
What class of drug is oxybutinin?
Antimuscarinic
What are the side effects of antimuscarinics?
- Dry mouth
- Dizziness
- Constipation
- Blurred vision
- Cognitive impairment
What is the definition of adherence?
The extent to which the patinet’s behaviour matches agreed recommendations from the prescriber
What is compliance the old term for?
What is it’s definition?
- Adherance
- The extent to which the patient’s behaviour matches the prescriber’s recommendations
What is concordance?
A process of prescribing and medicine-taking based of partnership
What are the reasons for non-adherence to medication regiemes?
What are the side effects of NSAIDs?
- GI adverse effects
Dyspepsia
Ulceration
Bleeding
What are the side effects of thiazide diuertics (e.g. Indapamide)?
- Can cause hyperuricaemia, which may exaccerbate gout
What is the made side effects of ACE inhibitors (e.g. lisinopril)?
- Cough
What is the main side effect of corticosteroids (e.g. Prednisolone)?
- Alter mood and behaviour
What side effects can antipsychotics cause (e.g. prochlorperazine)?
- Extra pyramdial side effects
What is the main side effect of statins?
- Myalgia
- Myositis
- Myopathy
What is an example of subjective monitoring of adherance?
A patient self reporting what they are taking
What is an example of objective monitoring of adherance?
Measuring concentrations of a drug in the blood
What is a monitored dosage system (MDS)?
Monitored Dosage System (MDS) is a medication management tool that organises a patient’s solid oral dose medication according to the day of the week and the time of day it should be taken. Also known as a blister pack,
HOW DO YOU ESTIMATE A PAEDIATRICS WEIGHT?
(Age+4) x 2(kg)
What do these stand for:
% w/w?
%w/v?
% v/v?
- % w/w = weight per weight = weight of a medicine (or chemical) added to a weight of a diluent
1% = 1g of a drug in 100 g of the final product - % w/v = weight of medicine is added to a voume of a diluent
1% w/v = 1g in 100 ml of final product - % v/v = volume of medicine is added to a volume of diluent
1% v/v = 1 ml of liquid drug in 100ml of the final product
What does 1 in 1000 represent?
1g in 1000 ml
= 1 mg per ml
What ages is:
Neonate?
Infant?
Adolescent?
- Neonate = up to 1 month
- Infant = up to 1 year
- Adolescent = 12-16 years
What is the conversion of oral morphine to SC and fentanyl patch?
What do corticoid steroids contain?
Mineralacorticoid and glucocorticoid
What is acetlcysteine?
Used in paracetamol overdose
What is the dosing of acetylcysteine?
- 1 hour in 200 ml of glucose 5% - For the first you need 150 mg/kg
- Second - over 4 hours in 500 ml of glucose 5% 50 mg/kg
- Third - over 16 hours, in 1 litre of glucose 5% - 100 mg/kg
- Total dose of 300 mg/kg over 21 hours
WHAT CAN BISPHOSPHONATES CAUSE IF THEY ARE CRUSHED?
- GI adverse effects
Which drug is contraindicated post stroke?
- NSAIDs
What can you do to Indapamide and Doxazosin for patients with swallowing difficulty?
- Crush them
Where is most oral medicaiton absorbed?
When might this be a problem?
- Small bowel
- If the patient has an ileus or short bowel conditon