1. Respiratory Drugs Flashcards

1
Q

Route of drug administration (3)

A

Inhalation (topical - applying to lung tissue via air flow)
ORal
IV

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2
Q

Drugs used in ventilation (2)

A

Improve airway patency

Prevent mast cell degranulation

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3
Q

Drugs used to improve airway patency (2)

A

Bronchodilators (B2 agonists)

Anti-inflammatories (corticosteroids)

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4
Q

Drugs used to prevent mast cell degranulation (2)

A

Chromoglycate

Leukotriene receptor antagonists

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5
Q

Drugs that impair ventilation (2)

A
B-blockers
Respiratory depressants (benzodiazepines, opioids)
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6
Q

Drugs used in gas exchange (2)

A

Respiratory stimulants - theophylline

Oxygen

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7
Q

Inhaled drug delivery methods (2)

A

MDI. - meter dose inhaler (puffer)

Breath activated device (spinhaler)

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8
Q

B-agonists can be (2)

A

Short acting

Long acting

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9
Q

Description of short-acting B-agonists (2)

A
Quick onset (2-3 mins), last 4-6hrs
Oral, inhalation, IV
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10
Q

Use of short-acting B-agonists

A

To treat acute bronchial constriction (asthma)

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11
Q

Examples of short-acting B-agonists (2)

A

Salbutamol

Terbutaline

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12
Q

Description of long-acting B-agonists (2)

A
Slow onset (1-2hrs), last 12-15hrs
Inhalation only
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13
Q

Use of long-acting B-agonists

A

To treat acute bronchial constriction

Always with inhaled steroid

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14
Q

Examples of long-acting B-agonists

A

Salmeterol

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15
Q

Action of anticholinergics (3)

A

Inhibit muscarinic nerve transmission in autonomic nerves
Bronchial dilation
Reduce mucus secretion

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16
Q

Example of anticholinergic

A

Ipratropium

17
Q

Action of corticosteroids

A

Reduce inflammation in bronchial walls

18
Q

Examples of corticosteroids (4)

A

Beclomethasone
Budesonide
Fluticasone
Mometasone

19
Q

Compound preparations involve (2) and example

A

Inhaled steroid
Long-acting b-agonist
Seretide - fluticasone/salmeterol

20
Q

Use of theophylline

A

Treat asthma and COPD

21
Q

Actions of theophylline (4)

A

Relax bronchial smooth muscle
Increase heart muscle contractility and efficiency
Increase HR
Increase BP, renal blood flow and anti-inflammatory effects