1, pharmacology of asthma

Question 1

whats the best vasodilating CCB

Answer 1

DHPs e.g. amlodipine (>diltiazem > verapamil)

Question 2

whats the best negatively isotropic CCB

Answer 2

verapamil

Question 3

example of a short and long acting nitrate

Answer 3

GTN = short

isosorbide dinitrate = long

Question 4

what is the NICE guidelines for stable angina for ongoing prophylaxis

Answer 4

1. BB OR CCB
2. BB + CCB
3. BB + CCB + either:
   long acting nitrate
   ivabradine
   nicorandil
   ranolazine

Question 5

what do beta blockers do to help angina

Answer 5

decreases cardiac contractility i..e negative inotrope

Question 6

what do calcium channel blockers do to help angina

Answer 6

increases ARTERIAL vasodilation which reduces after load (which therefore reduces preload)

Question 7

what to nitrates do to help angina

Answer 7

VENOdilator
dilates veins = lower CVP = lowers preload (end diastolic pressure)= reduces cardiac wall tension
reduces cardiac o2 demand