1. Organs of the immune system, Natural immunity; The complement system Flashcards
Organs of the immune system; Primary what is it made of
Thymus
*Bursa (B-equivalents): Embryonic liver Bone marrow
Organs of the immune system; secondary what is it made of
Lymph nodes
*Spleen
*MALT Mucosa Associated LymphTissue
*GALT Gut Associated LymphTissue
Natural immunity: Main molecular components
Complement factors and their receptors
o Heat shock proteins
o Fc receptors
o Inflammatory cytokines, histamine,
Natural immunity: Main cellular components
Macrophages
o Natural killer cells
o Granulocytes
o Dendritic cells
Natural immunity:Functional characteristics
None antigen specific
o No immunological memory
o Rapid reactivity
o Linear amplification of the reaction
Natural immunity: humoral factors
Complement system
o Lysosin
o C-reactive protein
o Interferon
The complement system: The cascade is activated in three ways:
Classic adaptive pathway
o Natural hereditary alternative pathway:
o MBL: mannose binding lectin
The complement system: The cascade is activated in three ways: classic adaptive pathway
Known antigen-antibody complex
The complement system: The cascade is activated in three ways: natural hereditary alternative pathway:
o unknown antigen appears
The complement system: The cascade is activated in three ways: MBL: mannose binding lectin
Binds oligosaccharides of certain virus/bacteria
The 3 Funtions of the Complement
- Complement has an intrinsic ability to LYSE bacterial membrane.
- Complement initiates CHEMOTAXIS, Complement-factors attract phagocytes to the site of the reaction.
- Stimulate OPSONIZATION, facilitating bacterial phagocytosis (resulting in Inflammation)