1- Mood Disorders Flashcards
Low mood, loss of interest/enjoyment, neuro vegetative disturbance, reduced energy, irritability/temper outbursts, and social/occupation dysfunction are sx of what disorder?
Major depressive disorder
Is MDD more common in men or women?
Women
What is the DSM5 criteria for MDD?
A. 5+ sx present for at least 2 weeks. 1 sx is either depressed mood or loss of interest or pleasure
- Depressed mood most of day, nearly every day,
- Diminished interest/pleasure
- Weight change
- Insomnia/hypersomnia
- Fatigue
- Feelings of worthlessness/inappropriate guilt
- Diminished ability to concentrate
- Thoughts of self harm/SI
B. Clinical impairment in social/occupation functioning
C. no due to physiologic effect of substance or GMC
D. Not better explained by schizophrenia/other disorder
E: Never had manic or hypomanic episode
What is disorder is Sig-E-Caps a pneumonic for? What does is stand for?
MDD
Sleep Interest Guilt Energy Concentration Appetite Psychomotor changes SI
What disorder is PHQ-9 screening used for?
MDD (score of ≥ 10)
What is the DSM5 criteria for Persistent depressive disorder?
A. Depressed mood for most of the day for most days for at least 2 yrs
B. Depressed + 2+ of the the following:
- appetite changes, sleep changes, energy changes, low self esteem, poor concentration, feelings of hopelessness
C. During 2 yr period (1 for peds), pt has never been w/o sx in Criteria A and B for more than 2 months
D. Criteria for MDD may be continuously present for 2 yrs
E. Have never been mania, hypomania, or cyclothymia
F. Does not occur during course of psychotic disorder
G. Not due to GMD or substance induced
H. Sx cause clinically significant distress/impairment
If pt has a response to tx of a depressive disorder this will result in what % improvement in sx?
50% (will be reflected by 50% increase in PHQ-9 score)
What does it mean if pt is in remission for a depressive disorder ?
SX w/in “normal” range of tests PHQ-9 ≤ 4
If pt is in remission for ≥ 6 months for a depressive disorder, what is this considered?
Recovery
What is the tx for mild to mod MDD?
- Antidepressant (SSRI, SNRI)
- Psychotherapy (CBT - individual, couple, group)
- Combined therapy (synergistic)
What is the goal of CBT therapy in pt w/ MDD?
- Education, coping skills, stress management
- To ID and correct incorrect beliefs
What is the goal of behavioral therapy for MDD?
Thought exercises or real experiences to reduce sx
What is the tx for severe MDD?
- Antidepressant (SSRI, SNRI)
- Psychotherapy (CBT )
- Combined therapy (synergistic)
- ElectroConvulsive therapy (if SI or food refusal)
What is the antidepressant course for antidepressants?
- SSRI (Prozac, Zoloft, Paxil)
- SSNI/SSRI (Effexor, Cymbalta)
- Miscellaneous (Wellbutrin)
- Combo w/ atypical antipsychotics
What is the DSM5 Criteria for Bipolar I?
A. At least 1 manic episode
B. Occurrence of manic and/or MDD episodes not better explained by other d/o on schizophrenia spectrum
How is a manic episode defined?
A. Distinct period of abn/persistently elevated mood ≥ 1 wk
B. During mood disturbance must 3+ of the following sx:
- Inflated self esteem, decreased sleep, more talkative, flight of ideas, distractibility, increased goal directed activity, excessive involvement in pleasurable activities
C. Marked functional impairment or hospitalization to prevent harm to self/others
D. Not due to drug or GMC
What disorder is DIGFAST a pneumonic for? What does is mean?
Mania
Distractibility Impulsivity Grandiosity Flight of ideas Activity (increased, goal directed) Sleep (decreased need) Talkative
What is the DSM5 criteria for Bipolar II disorder?
A. Presence/hx of at least 1 hypomanic episode & 1 MDD episode
B. Never had a manic episode
C. Not better explained by schizoaffective d/o
D: Depressive sx causing clinically significant distress/impairment in functioning
What is the criteria for hypomania?
A. Persistently elevated mood, lasting ≥ 4 days that is clearly different from non-depressed mood
B. During period of mood disturbance, 3+ Mania/DIGFAST sx
C. Clear change in function, uncharacteristic of person
D. Change in mood/function is observable by others
E. not severe enough to cause marked impairments. No psychosis
F. No due to drug or GMC
What disorder is the MDQ screening used for? Is is diagnostic?
Mood disorders (depression or biopolar)
Not diagnostic, only screening tool. If positive must be evaluated for depressive or bipolar disorder w/ DSM criteria
What is the med tx for Bipolar 1 (severe mania)?
1st line: Lithium or Valproate. AND 1st gen or atypical neuoleptic (Aripiprazole, Risperidone, olanzapine, quetiapine)
2nd line: Different anticonvulsant &/or atypical
3rd line: ECT
What is the med tx for Bipolar II (hypomania)?
1st line: Risperidone or olanzapine
2nd line: Different atypical or 1st gen antipsychotic or anticonvulsant
3rd line: Benzodiazepines
What is the non-med tx for Bipolar I and II?
- Psycho-education (depression bipolar support)
- Importance of med compliance/avoidance of substance abuse
- Circadian stability (regular sleep patterns)