[1] Maternal Diabetes (pre-existing DM) Flashcards
What percentage of pregnant women have pre-existing DM?
~0.4%
What is the most common type of pre-existing diabetes in pregnancy?
Type 1
Is pre-existing type 2 diabetes becoming more or less common in pregnancy?
More common
What women are more commonly affected by pre-existing diabetes?
Older, more obese and unplanned pregnancies
Which type of pre-existing diabetes has a higher rate of complications in pregnancy?
Both the same
What are the implications of pregnancy on pre-existing diabetes?
- Anti-insulin effects of placental hormones
- Vomiting in early pregnancy can complicate diet and medication balance
- Reduced ‘warning signs’ of hypoglycaemia
- Can accelerate retinopathy and nephropathy
What is the result of the anti-insulin effects of placental hormones in pre-existing diabetes in pregnancy?
Up to 3x larger insulin requirement
What are the implications of pre-existing diabetes on pregnancy in the first trimester?
- Increased rate of miscarriage
- Increased risk of congenital abnormality
What is the risk of miscarriage due to pre-existing diabetes related to?
Glycaemic control
What congenital defects does pre-existing diabetes increase the risk of?
- Neural tube defects
- Congenital heart disease
What is the risk of fetal abnormality in women with HbA1c >10 %?
25%
What are the implications of pre-existing diabetes on pregnancy in the second trimester?
- Pre-eclampsia
- Macrosomia
- Polyhydramnios
What other things can increase the risk of pre-eclampsia besides pre-existing diabetes?
- Hypertension
- Diabetic nephropathy
What are the implications of pre-existing diabetes in the third trimester of pregnancy?
- Still birth
- Growth restriction
When may women with pre-existing diabetes be likely to develop fetal growth restriction?
With pre-existing vascular disease or pre-eclampsia