1 - hypertension Flashcards
what is hypertension?
High blood pressure with systolic pressure of 140mmHg or above and diastolic pressure of 90mmHg or above
What is blood pressure?
it is the pressure exerted by the blood on the walls of the blood vessels
what determines blood pressure?
cardiac output = heart rate X stroke volume
what is pulse pressure?
its the difference between the systolic and diastolic pressure (120/80 has a pulse pressure of 40)
what is the mean arterial pressure? (MAP)
is the pressure that propels the blood through the tissues.
MAP = diastolic pressure + 1/3 pulse pressure
what are factors causing an increase in MAP?
an increase in both cardiac output and peripheral resistance increase in BP and MAP.
what are factors that increase stroke volume and heart rate?
EDV = end diastolic volume - blood left in the left ventricle when the heart is fully relaxed.
ESV = end systolic volume - blood left in the left ventricle when the heart is fully contracted
how is BP regulated?
- renin angiotensin aldosterone system
- natriuretic peptide (ANP & BNP) release
- antidiuretic hormone ADH & regulation of blood volume
- renin is produced by the kidney, aldosterone retains salt and water in the kidneys, increasing blood volume & BP
renal control of BP through the renin angiotensin aldosterone system
- renin is released in response to low BP
- renin then acts on the plasma protein angiotensin to form angiotensin I
- angiotensin I is then converted into angiotensin II by an angiotensin converting enzyme (ACE)
what are the impacts of aldosterone release?
- increase sodium reabsorption means increased water reabsorption (osmosis)
- increased water reabsorption means increased blood volume
- increased blood volume means increased BP
what are the impacts of natriuretic peptide (NP) release?
- ANP (atrial natriuretic peptide) helps to reduce BP
- decrease in renin release & inhibits ADH & aldosterone release
- a decrease in ADH & aldosterone will reduce water reabsorption & sodium retention, lowering blood volume and BP
- decreased ang II also causes vasodilation & decrease BP
- BNP equally important - released by ventricles
how does regulation of sodium and water balance maintain BP?
the renin angiotensin system, the release of ADH and neural regulation via the sympathetic nervous system all helps maintain BP homeostasis
- mechanisms don’t work alone, they are all interconnected
what is primary/essential hypertension
- no underlying cause
- cannot be cured, but can be controlled
- 90% cases of hypertension
factors that contribute to primary/essential hypertension
- hereditary and environmental factors
- diet, high salt intake
- obesity
- age, post 40 years
- diabetes
- stress
- smoking, nicotine is a vasoconstrictor
- excessive alcohol intake
how to control primary/essential hypertension
- diet constrictions of salt and cholesterol
- losing weight
- stop smoking
- reduce stress
- you CANT change your genetics
- you CAN change your lifestyle