(1) Heritability - mutations Flashcards
1
Q
What gene is responsible for schizo?
A
No single gene is responsible
2
Q
Linkage to susceptibility for schizo found for what pairs, but are they replicated?
A
21 of 23 chromosome pairs, but not replicated
3
Q
May be due to
A
rare mutations
4
Q
Different genes may cause schizo in
A
Different families and would be missed in population studies
5
Q
Mutation in
A
DISC1 (schizophrenia 1) - occurs rarely
6
Q
Is in some families with high incidence of schizophrenia: this gene is involved in
A
a. neuronal migration during development
b. neuronal differentiation and growth
c. guidance of axons during brain development
d. assembly of neurotransmitter receptors
e. formation of synapses
7
Q
Mutations in this gene also associated with…
A
depression, bipolar, autism
