1: Hemostasis And Coagulation

Question 1

Key cellular components of hemostasis

Answer 1

1. Cells of the vascular intimate
2. Extravascular tissue factor (TF-bearing cells)
3. Platelets

Question 2

Refers to the role of blood vessels and platelets in the initial response to a vascular injury or to the commonplace desquamation of dying or damaged endothelia’s cells

Answer 2

Primary hemostasis

Question 3

Key players of primary hemostasis

Answer 3

Platelet and blood vessel

Question 4

End product of primary hemostasis

Answer 4

Platelet plug

Question 5

Describes the activation of a series of coagulation proteins in the plasma, mostly serine proteases, to form a fibrin clot

Answer 5

Secondary hemostasis

Question 6

Key players of secondary hemostasis

Answer 6

1. Coagulation system
2. Enzymes and cofactors
3. Platelets

Question 7

End product of secondary hemostasis

Answer 7

Stabilized fibrin clot

Question 8

The final events of homeostasis

Answer 8

Fibrinolysis

Question 9

The gradual digestion and removal of fibrin clot as healing occurs

Answer 9

Fibrinolysis

Question 10

Key players of fibrinolysis

Answer 10

Fibrinolytic system

Question 11

End product of fibrinolysis

Answer 11

Dissolution of fibrin clot

Question 12

Timing of hemostasis

Answer 12

Primary
- vasoconstriction
- platelet adhesion
- platelet aggregation

Secondary
- activation of clotting factors
- fibrin formation

Fibrinolysis
- activation of fibrinolytic factors
- clot lysis

Question 13

Occupy the connective tissue layer and produces collagen

Answer 13

Fibroblasts

Question 14

Tunica adventitia is composed of

Answer 14

Connective tissue cell-support

Question 15

Thickest coat of blood vessel

Answer 15

Tunica media

Question 16

Tunica media is consists of

Answer 16

Elastic tissue and smooth muscles

Question 17

Allows the blood vessel to contract and regulate blood flow

Answer 17

Tunica media

Question 18

Tunica intima is for

Answer 18

Vasoconstriction and vasodilation

Question 19

Tunica intima contains

Answer 19

Endothelial cells

Question 20

Hemostatic components of a vascular system

Answer 20

1. Extravascular tissue
2. Subendothelial tissue
3. Endothelial cell (ULWF)

Question 21

Vascular intima of the blood vessel:

Innermost vascular lining

Answer 21

Endothelial cells

Question 22

Vascular intima of the blood vessel:

Supporting the endothelial cells

Answer 22

Internal elastic lamina composed of elastin and collagen

Question 23

Vascular intima of the blood vessel:

Subendothelial connective tissue

Answer 23

Collagen and fibroblasts in veins
Collagen, fibroblasts, and smooth muscle cells in arteries

Question 24

Separating procoagulant proteins and platelets in blood from collagen and tissue factor in fibroblast and smooth muscle cells

Answer 24

ECs us a physical barrier

Question 25

Anticoagulant properties of vascular intima

Answer 25

1. Nitric oxide 2. Prostacyclin 3. Tissue factor pathway inhibitor 4. Thrombomodulin 5. Endothelial protein C receptor 6. Glycosaminoglycan heparan sulfate 7. Tissue plasminogen activator

Question 26

Anticoagulant properties of vascular intima “Relaxing factor"

Answer 26

Nitric oxide

Question 27

Anticoagulant properties of vascular intima Induces smooth muscle relaxation and subsequent vasodilation

Answer 27

Nitric oxide

Question 28

Anticoagulant properties of vascular intima Promotes angiogenesis and healthy arterioles

Answer 28

Nitric oxide

Question 29

Anticoagulant properties of vascular intima Eicosanoid platelet inhibitor

Answer 29

Prostacyclin

Question 30

Anticoagulant properties of vascular intima Vasodilator

Answer 30

Prostacyclin

Question 31

Anticoagulant properties of vascular intima Synthesized through the eicosanoid pathway

Answer 31

Prostacyclin

Question 32

Anticoagulant properties of vascular intima Controls the activation of the tissue factor pathway also called the Extrinsic Coagulation Pathway

Answer 32

Tissue Factor Pathway Inhibitor

Question 33

Anticoagulant properties of vascular intima Limits the activation of the TF:VIIa:Xa (Extrinsic complex)

Answer 33

Tissue Factor Pathway Inhibitor

Question 34

Anticoagulant properties of vascular intima Facilitated by the endothelial protein C receptor (EPCR)

Answer 34

Thrombomodulin

Question 35

Anticoagulant properties of vascular intima Catalyzes the activation of the protein pathway -> Protein C coagulation system activator

Answer 35

Thrombomodulin

Question 36

Downregulates coagulation by digesting activated factor C and VIII, inhibiting thrombin formation

Answer 36

Protein C pathway

Question 37

Anticoagulant properties of vascular intima Integral component of the protein C control system

Answer 37

Endothelial Protein C receptor (EPCR)

Question 38

Anticoagulant properties of vascular intima Regulates thrombin generation

Answer 38

Glycosaminoglycan Heparan Sulfate

Question 39

Anticoagulant properties of vascular intima Enhances the activity of antithrombin, a blood plasma serine protease inhibitor

Answer 39

Glycosaminoglycan Heparan Sulfate

Question 40

Anticoagulant properties of vascular intima Activates fibrinolysis

Answer 40

Tissue Plasminogen Activator

Question 41

Procoagulant Properties of Vascular Initima

Answer 41

1. Vasoconstriction 2. Collagen 3. VWF 4. ADAMTS-13 5. P-selectin 6. Intercellular Adhesion Molecule (ICAMs) 7. Platelet Endothelial Cell Adhesion Molecule (PECAMs) 8. Smooth Muscle Cells and Fibroblasts 9. Tissue Factor

Question 42

Procoagulant Properties of Vascular Initima Is the contraction of blood vessels

Answer 42

Vasoconstriction

Question 43

Procoagulant Properties of Vascular Initima Binds VWF; binds and activates platelets

Answer 43

Collagen

Question 44

VWF is from storage site called

Answer 44

Weibel-parade bodies

Question 45

Procoagulant Properties of Vascular Initima Binds platelets to exposed subendothelial collagen -> necessary for platelet adhesion to collagen at the site of the injury

Answer 45

VWF

Question 46

Procoagulant Properties of Vascular Initima Described as a "carpet"

Answer 46

VWF

Question 47

Procoagulant Properties of Vascular Initima Carrier to factor VIII, primarily binds to platelet membrane receptor GPIb to promote adhesion

Answer 47

VWF

Question 48

Procoagulant Properties of Vascular Initima Cleves large vWF multimers into shorter chains that support normal platelet adhesion

Answer 48

ADAMTS-13

Question 49

Procoagulant Properties of Vascular Initima VWF regulator

Answer 49

ADAMTS-13

Question 50

ADAMTS-13

Answer 50

A disintegrin-like metalloproteinase with thrombospondin motif type 1 member 13

Question 51

Procoagulant Properties of Vascular Initima Adhesion molecule that promotes platelet and leukocyte binding

Answer 51

P-selectin

Question 52

Procoagulant Properties of Vascular Initima Immunoglobulin-like adhesion molecules and further promote platelet and leukocyte binding

Answer 52

ICAMs and PECAMs

Question 53

Procoagulant Properties of Vascular Initima Support the constitutive membrane protein tissue factor

Answer 53

Smooth muscle cells and fibroblasts

Question 54

Procoagulant Properties of Vascular Initima Tissue factor

Answer 54

FVII and TFPI

Question 55

White clot

Answer 55

Platelets and vWF Arteries and arterioles

Question 56

Red Clot

Answer 56

Platelet, vWF, Fibrin, RBCs In veins

Question 57

Fibrinolytic Properties of Vascular Intima

Answer 57

1. Tissue Plasminogen Activator (TPA) 2. Plasminogen Activator Inhibitor-1 (PAI-1) 3. Thrombin Activatable Fibrinolysis Inhibitor (TAFI)

Question 58

Fibrinolytic Properties of Vascular Intima For removal of fibrin to restore vessel patency

Answer 58

Tissue Plasminogen Activator

Question 59

During thrombus formation, ____ and ____ bind to polymerized fibrin

Answer 59

Tissue Plasminogen Activator and Plasminogen

Question 60

Fibrinolytic Properties of Vascular Intima Activates fibrinolysis by converting plasminogen to plasmin

Answer 60

Tissue Plasminogen Activator

Question 61

Fibrinolytic Properties of Vascular Intima TPA control protein that inhibits plasmin generation and fibrinolysis

Answer 61

Plasminogen Activator Inhibitor-1

Question 62

Fibrinolytic Properties of Vascular Intima Thrombin-thrombomodulin complex

Answer 62

Thrombin Activatable Fibrinolysis Inhibitor (TAFI)

Question 63

Fibrinolytic Properties of Vascular Intima Activated by thrombin bound to EX membrane thrombomodulin

Answer 63

Thrombin Activatable Fibrinolysis Inhibitor (TAFI)

Question 64

Activators of Fibrinolysis

Answer 64

Tissue Plasminogen Activator Urokinase Plasminogen Activator

Question 65

Control of Fibrinolysis

Answer 65

1. Plasminogen Activator Inhibitor-1 (PAI-1) 2. A2- antiplasmin 3. Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)