1. fear assoc with amyg (damage studies)

Question 1

describe urbach-weith disease

Answer 1

hardening brain tissue in medial temporal lobe (amyg sits in anterior MTL)
orality, lack of fear
- kluver-bucy syndrome in primates

Question 2

patient sm

Answer 2

adolphs et al
bilat amyg damage - calcification
IQ normal - trouble recog, generating and drawing fear expresions
no problem with other emotions

thought to be assoc with lack of assoc of salient facial features in expression ie eye widening with fear/threat-

bechara - not condition to aversive stimuli in CC - describe procedure + present fear response

Question 3

problems with case studies such as sm

Answer 3

no past history

can say for sure that only amyg lesion causing the behavioural response

Question 4

describe le doux rat paradigm

Answer 4

CC of tone with shock - freezing beh
lesions (connections elsewhere in tact) in amyg abolish fear conditioning down the sensory processing pathway

lesions to thall acts as relay centre of sensory info and also prevents conditioning - amyg not recieve the info

Question 5

why is CC pairing more robust against extinction when pairings are infrequent in learning?

Answer 5

based on expectation
when the presentation of the threat following a stimuli is infrequent it induces a level of uncertainty

in extinction - remain weary that could still appear after time of no pairings

Question 6

le doux high road

Answer 6

thall - visual cortex - amyg

Question 7

le doux low road

Answer 7

thall - amyg

crude, fast, rapid procesing

Question 8

le doux model with fear conditioning

Answer 8

1. CS processed in central thall (MGN/LGN)
2. convey to lat nucleus of amyg (LN)

3, to central nucleus of amyg (ce)

4. Hypothallamus - output to regions assoc with internal reactions, activates ANS/PNS
   + Basal nucleus output to NAcc and VP for motor

Question 9

brain regions involved in pavlovian fear conditioning

Answer 9

Somatosensory thalamus to-

Lateral Nucleus of the amygdala to-

Central Nucleus of the amygdala to-

Hypothalamus

Question 10

role of hipp with amyg

Answer 10

conditioning in the CONTEXT
greater mag response to CS when in a specific context assoc with it
if lesioned - no conextual conditioning - generalised (PTSD)