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Blood and Lymph - Leukemias > 1 > Flashcards

1 Flashcards

1
Q

APML

A

t(15;17) PML-RARA

tx: ATRA+arsenic
complications: DIC

very good prognosis

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2
Q

Good prognoses - AML chromosomal abnormalities

A

t(8;21) RUNX1

t(16;16) or inv(16) CBFB

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3
Q

Good markers for AML

A

NPM1 and CEBPA mutations

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4
Q

Bad marker for AML

A

FLT3 internal tandem duplications

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5
Q

t-AML causes

A

alkylating agents -> lose Chr5/7

topoisomerase II inhibitors -> rearrange 11q23 MLL

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6
Q

Poor prognoses - AML chromosomal abnormalities

A

t(1;22) RBM15-MLK1 (megakaryoblasts)

11q23 MLL abnormalities

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7
Q

CML

A

t(9;22) BCR-ABL 210kD protein

Tx: Gleevec

Good prognosis

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8
Q

Good prognosis - B-ALL chromosomal abnormalities

A

t(12;21) RUNX1

Otherwise, best if ages 1-10, if B-ALL vs T-ALL, and with hyperdiploidy

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9
Q

Bad prognoses - B-ALL chromosomal abnormalities

A

t(9;22) BCR-ABL 190kD protein

11q23; MLL

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10
Q

Classical Hodgkins - best prognosis and worst prognosis

A

Best prognosis is lymphocyte-rich Hodgkins

Worst is lymphocyte-poor

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11
Q

Defining feature of Nodular Lymphocyte-Predominant Hodgkins

A

Popcorn cells - multilobated nuclei

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12
Q

Mantle cell Non-Hodgkin’s B-CLL

A

t(11;14) IgH -> Cyclin D (G1->S)

“small”

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13
Q

Marginal zone Non-Hodgkin’s B-CLL

A

Associated with chronic infl., marginal zone only exists if B cells are proliferating ya dummy

“small”

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14
Q

Follicular Non-Hodgkin’s B-CLL

A

t(14;18) IgH -> BCL2 -|apoptosis

“small”

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15
Q

Burkitt’s lymphoma

A

Non-Hodgkin’s B-CLL, intermediate size

IgH -> c-myc (oncogene)

defining features: in Africans, see a jaw mass
Starry sky appearance of blood slides

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16
Q

Large cell B-CLL

A

very diffuse, very aggressive

17
Q

Defining features of a plasma cell neoplasm

A

Rouleaux formation

IL-6

M spike

18
Q

Rouleaux formation

A

RBCs stack on each other in smear

19
Q

Defining feature of Hodgkin’s lymphoma

A

Reed-Steinberg cell, immature B cell which produces tons of cytokines

Blood and Lymph - Leukemias (2 decks)

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