1/2020 Opioids

Question 1

Skeletal Muscle Rigidity in opioids

Answer 1

More common with the potent lipophilic compounds such as SUFENTANIL, REMIFENTANIL, FENTANYL, ALFENTANIL,

Believed to result from mu receptor stimulation in the CNS [ultimately influencing dopamine and GABA motor pathways]

Chest wall rigidity, laryngeal muscle rigidity, neck and extremity rigidity.

Question 2

CYP3A4 inhibitors

Answer 2

will increase the amount / levels / effects of opioids

Azole, Cipro, doxy, clarithromycin, erythromycin, diclofenac, propofol, protease inhibitors.