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Question 1

PET is nearly universally positive at diagnosis inDLBCL, FL and nodal MZL, but less sensitive for _____.

Answer 1

Extranodal MZL

Question 2

Latge population based studies have demonstrated a strong associatiob between seropositivity for HCV abd development of B-cell lymphoma. The prevalence was increased among ____ and ____

Answer 2

DLBCL
MZL

Question 3

Direct acting antiviral agents (DAA) approved for tx in combination with PEG interferon and ribavirin of pxs with HCV genotype 1 infection

Answer 3

Telaprevir
Boceprevir

Question 4

Used for pxs with significant renal dysfunction receiving high dose methotrexate

Answer 4

Glucarpidase

Question 5

Components of FLIPI-2 (5)

Answer 5

Age
Hemoglobin
Longest diameter of largest involved lymph nide
B2 microglubin
Bone marrow involvement

Question 6

Gelf Criteria (7)
-clinically useful to guide initiation of tx in Follicular lymphoma

Answer 6

1. Involvement of >/= 3 nodal sites, each with a diameter of >/= 3 cm
2. Any nodal or extranodal tumor mass woth a diameter of >/= 7cm
3. B symptoms
4. Splenimegaly
5. Pleural effusion or peritoneal ascites
6. Cytopenia (leukocytes <1 x 10^9/Lor platelets <100)
7. Leukemia (>5 x 10^9/L)

Question 7

Has a critical role in the pathogenesis of EMZL of stomach. It’s eradication can lead to tunor remisssion

Answer 7

H.pylori

Question 8

Preferred regimen for FL high tumor burden

Answer 8

1. BR or OR
2. CHOP + O or R
3. CVP + O or R
4. Lenalidomide + rituximab

Question 9

Definition of Laboratory TLS

Answer 9

25% increase in levels of serum uric acid, potassium, phosphorus
25% decrease in calcium levels

Question 10

IPI (5)

Answer 10

1. Age > 60yrs
2. Serum LDH > normal
3. PS 2-4
4. Stage III or IV
5. Extranodal involvement > 1 site

Low 0-1
Low-int 2
High - int 3
High 4 or 5

Question 11

CNS-IPI

Answer 11

Age > 60yrs
LDH > Normal
PS> 1
Stage III or I
Extranodal involvement or > 1 siye
Kidney or adrenal involvement

Low 0-1
Int 2-3
High 4-6 or kidney or adrenal involvement