1 Flashcards
Exercise & A1C
8+ weeks of exercise shown to decrease A1C by 0.6% in T2DM even if no weight loss occurs.
DM Exercise Recommendations
light activity q30 mins while awake for BGC
Initial T2DM Management
1) Set A1C goal
2) Reduce CV RFs
3) Evaluate use of metformin
4) PE & monitoring
Which medications are associated with an increased r/f development of T2DM?
- Glucocorticoids
- HCTZ
- Atypical antipsychotics
- HMG Co-A reductase inhibitors
- & more!
ADA goals for A1C in T1DM
< 6%
Fibromyalgia body sites
widespread pain index
neck jaw shoulder girdle upper & lower arm chest abdomen upper & lower back upper & lower leg hip (trochanters)
Kyphosis
- Older adults can lose 1-3” of height
- Height loss c/b compression fractures of vertebrae
- Most commonly occurs after 70 y/o
- Generally caused by osteoporosis of vertebrae
- Appears as “hump” in thoracic region
- Most common in elderly females
- Sx that may occur with severe cases include: difficulty breathing, fatigue, and back pain.
Scoliosis
abnormal lateral curvature that occurs most often during the growth spurt just before puberty
Lateral Epicondylitis
AKA “tennis elbow”
• Inflammation of tendon insertion of the extensor carpiradialis brevis muscle.
• Associated with lateral tenderness at insertion site
• Pain worsens with grasping or
twisting
Medial Epicondylitis
AKA golfer’s elbow
• Associated with pulling pain
hyperextension
Elbow pain with extension is indicative of hyperextension
Probenecid (Probalan)
- Uricosuric agent used to increase renal excretion of uric acid in you patients.
- Does not affect formation of uric acid.
- Uric acid is not metabolized; it is excreted.
Scoliosis Curvature
- Curvatures >40° requires surgical implant of Harrington rod.
- Curvatures 5-20° should be monitored for changes.
- Curvatures 20-40° require bracing.
Avascular necrosis
lack of blood flow to bone(s) causes bone death
Colles’ fracture
- Most common type of wrist fracture
* AKA “dinner fork fracture” because of the appearance of arm and wrist fracture.
Diagnostics for ankylosing spondylitis (AS)
• MRI & XR to assess for changes in joints and bones.
• HLA-B27 is a genetic marker present in 95% of those with the disorder.
• CRP & ESR = markers of inflammation; however, not present in all AS cases
patients.
Baker’s cyst
swelling caused by fluid from the knee joint protruding to the back of the knee
positive Kernig’s sign
Patient will resist leg straightening when hip is flexed as a result of painful hamstrings from lumbar nerve root inflammation.
positive Brudzinski sign
patient’s neck is passively flexed and there is flexing of the hips and knees to relieve pressure and pain
Nuchal rigidity
touching the chin to the chest causes pain
positive Babinski reflex
toes fan when the plantar surface is stroked from the heel to the great toe. Adults should have a negative Babinski reflex
Polymyalgia Rheumatica
• Treated with oral corticosteroids s/a prednisone.
• A hallmark of the disorder is dramatic improvement of sx after starting oral prednisone.
• Usually, sx can be controlled with long-term (2-3 years) low-dose oral prednisone, which can be tapered when sx are under
control.
• Usually a self- limiting illness (a few months to 3 years).
The fat pads on an infant’s feet can mimic ___ ______.
pes planus
Bruised kidney
S/S: • back pain • Muscle spasms • N/V • Direct hit to the side of the body
Appendicitis
Typically begins with anorexia and N/V for the first 12-24h. Diffuse abdominal pain = late sign. Usually diffuse at first and gradually localizes to RLQ.
ruptured vertebral disc
Manifests as pain and muscle spasm without N/V
Suspected cauda equine
syndrome
• New-onset saddle anesthesia • Worsening sciatica • Decreased DTRs of lower extremity on affected side. • Initial action = order MRI ASAP • Patient needs to f/u with a neurologist ASAP
pain medication for a child <12 years
Regular-strength Tylenol = safest
Grade III ankle sprain
• Possible complete rupture of some of the ligaments. • Unable to bear weight and walk • Lots of ecchymoses with malleolar tenderness. • Needs XR plus possible US and/or MRI). • Refer to ED
most common RFs for development of polyneuropathy
DM and ETOH abuse
Transillumination of hydrocele
will show that light glow is much larger and brighter on the affected scrotum, compared with the unaffected one
drugs that cause ED
1) SSRI (Paxil = worst)
2) ACEIs
3) CCBs
4) BBs
5) benzodiazepines
6) antihistamines
Risk factors for breast CA
- obesity (BMI of 30+
- older age
- moderate-to-high intake of ETOH
- first pregnancy at age 30 or older
- early menarche (before age 12)
- late menopause (55 or older)
- hx of breast mass w/ atypical hyperplasia
- positive FMH
- genetic mutations (BRCA 1 & 2)
Etonogestrel implant (Nexplanon)
progesterone-only
What is the is priority action when a patient presents with any eye complaint that is not an emergent situation?
Snellen (visual actuity)
Aspirin toxicity
- vomiting, confusion, and tinnitus
- immediately discontinue
presbycusis
- Normal, age-related hearing loss
- sensorineural hearing loss
Sensorineural hearing loss would show as a Weber test that lateralizes to the __________ ___.
unaffected ear
Acute closed angle glaucoma
- Sudden, severe onset unilat. eye pain + decreased visual acuity
- Blurry / impaired vision
- Eye is firm to touch
- DX = tonometry to test for increased IOP
- Refer to ED ASAP if suspected b/c of r/f permanent vision loss
- May see halos or rings
pterygium
- Overgrowths of conjunctiva
- Frequently present as eye redness and irritation.
- **Encroaches onto the cornea
- Patients usually don’t seek tx until discomfort or vision changes
In conductive hearing loss, sound lateralizes to the ________ ___ during a Weber test.
affected ear
chalazion
- presents as painless, localized eye swelling.
- distinguishing factor b/t a chalazion and hordeolum: chalazion = painless, without erythema
- Tx = moist, warm compresses to the area several x/day
What ABX route is needed to tx MRSA?
oral (at least)
Contact dermatitis is usually _____ onset and not usually ___________.
acute; symmetrical
Varicella vaccine, like most vaccines is not
100% effective at prevention.
What can Kerley B lines on XR indicate?
pulmonary edema or malignancy
Who should consider getting varicella titers drawn?
- HCPs and their families
- immunocompromised persons
Clostridium tetani
- gram positive
- found in soil (esp. manure)
Hep A
- transmitted fecal-oral (shed in stool)
- vaccine is not live
- peak infectivity = 2 weeks before jaundice onset or increase in liver enzymes
- RFs = MSM, travel (food prep)
- usually self-limiting
Polio transmission
fecal-oral
Major s/e of Chantix (varenicline)
- mood changes
- depression
- agitation
- suicidal ideation
Bells’ Palsy is r/t viruses such as:
- HSV
- Herpes zoster
- EBV
- cytomegalovirus
- adenovirus
- Rubella
- mumps
Hypochromic anemia
- Hypochromic RBCs = pale in color
- microcytic anemias are hypochromic in nature
How does metformin improve sx of PCOS?
Metformin decreases insulin resistance and increases insulin sensitivity. This leads to hormone reduction, thus improved cycles.
What condition will show “string of pearls” on US?
PCOS: characteristic multiple small follicles seen on TVUS while visualizing ovaries
Speed’s test assesses what 2 conditions?
- labral tears
- biceps tendonitis
What are we concerned about in a patient with a hx of smoking who has new onset throat pain and hoarseness lasting longer than 3 weeks?
Laryngeal CA; Refer them to ENT.
Anemia of chronic disease
Usually normochromic, normocytic.
normal MCV level
80-100 fL
What interventions can help prevent the osteopenia from developing into osteoporosis?
- Aldrenonate (Fosamax) to increase bone density
- Lifestyle interventions (WB exercise)
- Calcium 1200mg + Vit D 800-1000IU daily
DEXA scans
Start @ 65 (younger in pts w/ incidence of low-trauma frax)
Normal: > -1.0
Osteopenia: -1.0 to -2.5
Osteoporosis: < -2.5
weight-bearing exercises
Walking or jogging / weight lifting / yoga
What doesn’t count? Biking and swimming
dopamine agonists (medications that increase dopamine)
Pramipexole, Ropinirole, or Rotigotine
Heberden’s nodes
- Seen at DIPJs
- Only seen in OA
Test to evaluate RCT:
Drop-arm test: abduct arm laterally to 90° and have patient lower it back down to waist slowly. Positive if arm drops suddenly to side (weakness).
Test to evaluate shoulder impingement:
Neer’s test: stabilize patient’s scapula w/ 1 hand, while passively flexing arm while it is internally rotated. Positive if pain in this position.
Hawkin’s test: place patient’s arm in 90° of shoulder flexion w/ the elbow flexed to 90° and then internally rotate the arm. Positive if pain with internal rotation.
Oral Steroids for COPD Exacerbations
- Shorten recovery time
- Improve lung fx (FEV,) & arterial hypoxemia (PaO2)
- Reduce the r/f early relapse, tx failure, and hospital LOS
- Recommended 40 mg pred qd x5d
goal INR of a patient who has had a
stroke
2.0 to 3.0
Goal INR of a patient with A-Fib
2.0 to 3.0
goal INR of a patient with prosthetic valve
2.5 to 3.5.
AHA/ACC Dyslipidemia Recommendations
1) Hx CHD/CVA need 50% reduction
2) LDL > 190 need 50% reduction
3) DM; 40-75 y/o; LDL 70-189 need 30-49% reduction
4) ASCVD 10y risk score ≥ 7.5% need 30-49% reduction
50+% = High potency 30-49% = Moderate potency
Thiazides drop SBP by _________.
≈ 2-8 points.
Systems adversely affected by NSAIDs:
- CV
- Integumentary (e.g., SJS)
- Hematopoietic (b/c ASA affects platelets)
ABX & myasthenia gravis
Contraindicated:
•E. Mycin & telithromycin
• b/c of r/f respiratory collapse
Birth control & tetracycline
• Use backup method when taking
and for one pill cycle afterward
• The meds don’t have to be
taken separately
Avoid prescribing these drug classes to patients with sulfa allergies:
- thiazides
- loop diuretics
- some protease inhibitors (e.g., darunavair, fosamprenavir),
Reye’s syndrome
A rare condition that can develop in
children & young adults recuperating from febrile viral infections who ingest ASA or salicylate meds.
The condition can progress quickly.
Stage 1) sx = severe vomiting, diarrhea, lethargy, stupor, and elevated ALT + AST.
Stage 2) personality changes, irritability, aggression, and HYPERactive reflexes.
Stages 3-5) confusion, delirium, cerebral edema, coma, seizures, and death.
Side effects of thiazide diuretics
- hyperglycemia,
- hyperuricemia
- hypertrigs
- renal dz
- hypokalemia
- hyponatremia
- hypomagnesemia
Chlamydia trachomatis
- positive NAAT
- Treat both the patient & partner
- Preferred tx = azithromycin 1g PO x single dose
Can also do: doxycycline 100mg PO BID ×7 days
digoxin toxicity
• N/V, confusion, and yellowish
green halos in the patient’s vision.
• Can cause hypokalemia and
hypercalcemia.
Lithium toxicity
- Seizures
- Slurred speech
- Increased urination
- Increased thirst
“Seizing & slurring, drinking & peeing”
Phenytoin (Dilantin) toxicity
- nystagmus
- ataxia
- confusion
Carbamazepine (Tegretol) toxicity
skin rash & jaundice
Thiazide diuretics ________ calcium
excretion by the kidneys and _________
osteoblast production.
decrease; stimulate
Which med can be prescribed to manage both HTN and BPH?
Terazosin (Hytrin) = a quinazoline
Chronic use of NSAIDs is associated with increased risk of:
• ulcers • perforation • bleeding of the GI tract • heart attacks • CV damage • strokes • acute interstitial nephritis & kidney injury • liver damage. • can also affect lungs in those w/ asthma or underlying ASA sensitivity, causing bronchospasm
Levothyroxine (Synthroid) interactions
- anticoagulants
- tricyclic antidepressants
- antacids
- calcium, iron, multivitamins
- PPIs
- estrogens
- statins
- metformin.
Certain foods interfere with
absorption. Avoid taking them together and space these
foods and drugs several hours apart:
- calcium-fortified foods
- dietary fiber
- walnuts
- soy
ABX for cat/dog/human bite in patient w/ PCN allergy:
Bactrim
combination of a statin with niacin raises the risk of:
drug-induced hepatitis & rhabdomyolysis
first-line ABX tx for an infant with pertussis:
macrolides
(azithromycin, erythromycin,
clarithromycin)
Tx for first episode of primary genital herpes
Acyclovir (Zovirax)
400 mg PO tid x7-10 days
Tx for primary syphilis (chancre),
secondary syphilis, or early latent syphilis (<1 year):
Benzathine penicillin G 2.4
mU IM in a single dose
Podofilox (Condylox) 0.5%
• gel or cream • recommended tx for condylomata acuminata (genital warts), which may appear on the vagina, external genitals, urethra, anus, penis, nasal mucosa, oropharynx, or conjunctivae. • BID x 3 consecutive days
Hydrochlorothiazide (Procardia XL) can cause________________________, leading to ___________.
bone marrow suppression; neutropenia
Average benzodiazepine half-lives:
Triazolam (Halcion) ≈ 2h
Alprazolam (Xanax) ≈ 12h
Lorazepam (Ativan) ≈ 15h
Clonazepam (Klonopin) ≈ 34h
best choice for an elderly patient with insomnia
Zolpidem (Ambien)
Quick onset (15 min) Short half-life (2h)
What type of electrolyte should an
individual with primary HTN increase in their diet?
Potassium: aim for 3,500-5,000mg per day preferably from dietary sources.
Foods high in potassium include: • avocados • sweet potatoes (yams) • coconut water • bananas • oranges • watermelon / cantaloupe /honeydew •apricots • grapefruit • dark leafy vegetables (spinach / broccoli) • edamame
After antihypertensive therapy is initiated, when should a patient’s BP be rechecked?
F/u in 1 month after initiating/adjusting an antihypertensive.
When under control, f/u can be in 3 months.
Ethnic groups at higher risk for heart disease & T2DM:
Mexican Americans
African-Americans
South Asians (e.g., India, Pakistan)
most common cause of death for
people with DM
Heart disease
Common to hear a _____ __ heart sound over the ________ ____ of the heart with ___________. As long as it disappears with _________, with no other abnormal sx, this is a normal finding.
The sound is caused by the splitting of the ______ & _________ components.
split S2; pulmonic area; inspiration; expiration
aortic & pulmonic
Initial Warfarin dosing for A-fib:
patients > 70 years = 2.5 mg,
younger patients = 5 mg
Still’s murmur
- benign murmur, common in school-age children, usually resolves by adolescence
- murmur sound = musical quality with minimal radiation
Homan’s sign
calf pain at dorsiflexion of the affected limb
A sign of a DVT, but not definitive.
S4 sounds like…
“Tennessee”
S4 is aka atrial gallop or atrial kick
best heard @ apical area using the bell
S3 sounds like…
“Kentucky.”
S3 is aka ventricular gallop or S3 gallop
In coarctation of the aorta, BP is higher in the _______ than in the _______ because of the _______ in the aorta.
Arms; legs; narrowing
Test to evaluate SLAP tears:
O’Brien’s test:
1) Patient can sit or stand. Arm is placed in 90° of shoulder flexion and 10-15° of horizontal adduction.
2) Patient fully internally rotates shoulder & pronates elbow.
3) Examiner provides a distal stabilizing force as patient is instructed to apply an upward force.
4) Repeat in a neutral shoulder and forearm position.
Positive when pain is reproduced or clicking in the shoulder with the first position and reduced/absent with the second position.
Superficial pain usually = ACJ sx
Deep pain usually = labral sx
Keratosis pilaris is often d/t skin getting too dry and follicles getting plugged. What do you do?
Exfoliate (with something like a karyolitic) to prevent clogging
&
moisturize to prevent dryness
Siolithiasis can cause:
- pain and swelling of face, jaw, and neck tht is worse before/during eating (when saliva production increases)
- dry mouth
- foul taste/smell
Parotitis can occur with:
- mumps
-sialolithiasis
bulimia
S/S of erysipelas
- fever
- chills
- h/a
- malaise
are may be raised and/or have central clearing
Anthrax
Starts off as small, itchy bumps that progress to painless ulcer with black center that scabs over.
TX = ABX x7-10 days (cipro or doxy)
When do you close face wounds?
within 24h
When do you close extremity/trunk wounds?
within 12-18h
Tx for cat/dog/human bites
- clean
- empiric ABX (augmentin)
- do not close
When can you close a wound?
- Once you’ve ensure there are no RFBs (check with XR if unable to visualize fully)
- Once they’re clean
- If they do not involve deep structures (tendons, joints, etc.)
What type of acne are closed comedones without papules/pustules?
non-inflammatory / mild
How do you treat non-inflammatory / mild acne?
Benzoyl peroxide
Blepharitis
Inflammation of eyelids. They become red & itchy. Often produce scales on lashes.
Usually r/t inflammatory processes s/a rosacea, AD, seborrheic derm
Tx for bacterial conjunctivitis
- otic macrolide (e-mycin): ointment or drops
- once on ABX x24h, no longer contagious
- wash everything thoroughly
Lifestyle changes for macular degeneration
- quit smoking
- control BP
- Mediterranean diet
- weight loss to tx correlating dz processes
- utilize larger print and brighter lights
Corneal abrasion sx
- acute onset eye pain
- excessive tearing
- photophobia
- “something is stuck in my eye”
Corneal abrasion dx
fluorescein stain = orange dye put in eye and blue ligt used to detect damage/FB
Corneal abrasion tx
NSAIDs & moisturizing drops
Iritis, aka…
“anterior uveitis”
- inflammation of uvea (middle layer of eye)
- pupil might be painful and firm to touch
“Dry” ARMD
- slow
- unilateral or bilateral
- notice most change when driving
- need brighter lights, larger prints
- blurry spots
- straight lines look bent/wavy (metamorphosia)
“Wet” ARMD
- often sudden vision changes/loss
- usually starts unilateral
- metamorphosia typically more severe
Herpes zoster (shingles) outbreak on face and near eyes. What is our concern?
CN5 has an ophthalmic branch that when infected with shingles virus can l/t permanent blindness
Examples of cholinesterase inhibitors:
Donepezil (Aricept)
Rivastigmine (Exelon)
Galantamine (Razadyne)
What do cholinesterase inhibitors do and when do we use them?
Prevent breakdown of acetylcholine (works in PNS)
Used to tx mild to moderate dementia
What is ginkgo biloba used for?
memory and cognition
**sometimes menopause sx
What is evening primrose used for?
Menopause sx
***sometimes in pregnancy to soften cervix
What is kava kava used for?
anxiety
What is valerian root used for?
insomnia
What is echinacea used for?
immune support
What area of the brain controls balance and coordination? What are some tests to evaluate it?
Cerebellum
Romberg / rapid arm movement
CN1
olfactory
CN2
otic
visual acuity (snellen)
CN3
oculomotor
focus / EOM motor / pupillary response
CN4
trochlear
CN5
trigeminal
CN6
abducens
outward EOM by LR muscle
CN7
facial
puff out cheeks, raise eyebrows, smile, etc.
CN8
vestibulocochlear
hearing & balance
CN9 & CN10
9) glossopharyngeal: innervates tongue and throat
10) vagus
9&10 often tested together by watching uvula rise and fall with pronation
CN11
accessory
CN12
hypoglossal
movement of tongue
Why should people with GI disorders be cautious when taking anticholinergics?
They slow down gastric emptying and can further aggravate GI dz
ex: PUD, UC, etc.
Wellbutrin is an ____
NDRI
What is one serious s/e of Wellbutrin?
can in crease likelihood of seizures
Which BBs are lipophilic?
Propranolol and metoprolol
Which BBs are hydrophilic?
Atenolol and sotalol
Initial tx for SVT
Valsalva: stimulates vagus nerve and slows down conduction through AV node, which lower overall HR
Cardiac causes of pulsus parodoxus:
- cardiac tamponade
- severe hypovolemia
- pericarditis
Pulmonary causes of pulsus parodoxus:
- COPD exacerbation
- PE
- OSA
- status asthmaticus
Aortic regurge
- high-pitched
- early diastolic crescendo
- LICS #3
- at end expiration when leaned forward
What do all newborns get at birth?
vitamin K & HBV vaccine
Who gets surfactant and why?
Primis born before 32 weeks that weigh less than 1300g get surfactant at birth to help with lung development (open alveoli).
What can we give to pregnant moms of primis to help stimulate surfactant in baby?
injectable betamethasone
false menses
- pink-red spotting in diaper
- d/t drop in maternal hormones
- usually resolves in 3-4 days
- benign
Varicella vaccine
- Life vaccine
- 2 doses: 1 @ 12 mos. & again @ 4-6 yrs.
- If rash develops after vax, stay away from immunocompromised/pregnant people until it clears
- primary prevention for shingles later
TDaP indications
- 11 to 12 y/o who previously completed DTaP
- 7 y/o if missed some or all of DTaP
- adults > 19 get it when:
- – pregnant or going to be around newborn
- – 65+
- – HCP
Female athlete triad
1) irregular menses/amenorrhea
2) decreased bone density (osteoporosis)
3) restrictive eating
Levels of prevention
P = “P”rimary: action to “P”revent a dz/dx
S = “S”econdary: “S”creening and early dx
T = “T”ertiary: “T”reatment/actions after dx is established