0b Spinal Cord Crash Course Flashcards
What type of cell bodies are sensory neurons?
pseudounipolar
name the 2 types of GSA sensory receptions
ProprioceptionExteroception
Track how GVA enters the spinal cord beginning with the peripheral process
peripheral process (runs back with GVEs), sympathetic chain ganglia, white rami communicantes, spinal nerve, DRG, dorsal roots
What type of cell bodies are motor neurons?
multipolar
What type of cell bodies are autonomic nerves?
multipolar
Where are cell bodies of the sympathetic nervous system located? (specific location within spinal cord & segments)
IMLCC; T1-L2
Where are cell bodies of the parasympathetic nervous system located?
S2-S4 & cranial nerves
What is the difference between monosynaptic vs polysynaptic reflexes?
interneurons in polysynaptic reflexes;monosynaptic reflex is direct conversion of sensory input to motor neurons
List spinal cord segments and the number of nerves each segment contains.How many nerves are there compared to vertebrae?
8 cervical nerves12 thoracic nerves5 lumbar nerves5 sacral nerves1 coccygeal nerve31 spinal nn. : 33 vertebrae
Dermatome C2/C3
posterior head and back
Dermatome C4-T2
adjacent in upper thorax
Dermatome T4
Nipple
Dermatome T10
Umbilicus
Dermatome S3/Co1
anus
Which spinal cord segments are part of the cervical enlargement? why?
C4-T1; brachial plexus & upper limbs
Which spinal cord segments are part of the lumbosacral enlargement? why?
L2-S3; lumbosacral plexus and lower limbs
Define Funiculi
bundle of nerve fibers forming a tract
list the 3 main Funiculi and their components
- Posterior Funiculus: Dorsal Column (medial leminiscus)
- Lateral Funiculus: Lateral Corticospinal Tract
- Anterior Funiculus: Spinothalamic Tract (anterolateral system)
Which 2 fasciculi & 2 nuclei are located in the dorsal medial leminiscus tract?
Fasciculus Gracilis (medial) Fasciculus Cuneatus (lateral)
Nucleus Gracilis
Nucleus Cuneatus
Lamina I
Posteromarginal Nucleus
Lamina II
Substantia Gelatinosa
Lamina III & IV
Nucleus Proprius
Lamina V + VI
Base of Dorsal Horn
Lamina III
Nucleus Proprius
Lamina IV
Nucleus Proprius
Lamina V
Base of Dorsal Horn
Lamina VI
Base of Dorsal Horn
Which laminae are located in the dorsal horn?
I-VI
Which lamina is located in the intermediate zone?
VII
Which laminae are located in the ventral horn?
VIII & IX
Where is lamina X located?
around the spinal central canal
Lamina VII (T1-L2)
Dorsal Nucleus of Clark
Lamina VII (T1-L2/3)
IMLCC
Lamina VII (S2-S4)
Sacral Parasympathetic Cell Column
Lamina VIII
interneurons and tracts receiving descending information
Lamina IX
Lower Motor Neurons
In Lamina IX, where are neurons that control axial muscles located?
medial
In Lamina IX, where are neurons that control extremities located?
lateral, only in spinal enlargements (cervical and lumbosacral)
Where is the Accessory Nucleus located? (lamina + spinal segment)
Lamina IX, medulla - C5
Where is the Phrenic Nucleus located? (lamina + spinal segment)
Lamina IX, C3-C5 (phrenic nerve – essential for breathing)
What is the difference between an intrasegmental and intersegmental reflex?
intrasegmental - occurs within the same spinal cord segment & intersegmental - involves multiple spinal cord segments
What occurs during Reciprocal Inhibition?
one group of muscles is excited (ipsilateral synergists) while the antagonist group is inhibited (ipsilateral antagonists)
What is Autogenic Inhibition (inverse myotactic reflex)? and why does this exist?
Protective inhibitory response to excessive tension in muscle fibers (monitored by Golgi Tendon Organ); exists so that muscles do not exert more force than bones and tendons can tolerate.
What is the Withdrawal/Flexor/Nociceptive Reflex?
a complex, intersegmental, polysynaptic reflex initiated by cutaneous receptors that involved the WHOLE LIMB. This enables withdrawal from painful or nociceptive stimulus.
How does the Crossed Extension Reflex occur? What does it do?
The Crossed Extension Reflex builds on the Withdrawal Reflex. It accompanies it with a simultaneous and opposite action in the contralateral limb. This maintains postural integrity during the withdrawal reflex.
Track the Dorsal Column/Medial Lemniscal System.
Primary Neuron: cell bodies in DRG –> Fasiculus gracilis/cuneatus –>synapse on nucleus gracilis/cuneatus (ipsilateral), Secondary Neurons called Internal Arcuate Fibers–> CROSS OVER in Medulla –> become Medial Lemniscus Fibers –> synapse on Ventral Posterolateral Nucleus VPL of Thalamus, Tertiary Neurons –> Somatosensory Cortex
What type of system is the Dorsal Column/Medial Lemniscal? What sense(s) does it transmit?
sensory/ascending; proprioception, touch, vibration, 2 point discrimination/fine touch
Track the Anterolateral/Lateral Spinothalamic Tract.
Primary Neuron: cell bodies in DRG –> ascend 2-3 segments & enter Zone of Lissauer –> synapse on Dorsal Horn Laminae 1, 2, 5, & become Secondary Neurons –> CROSSES OVER at the anterior white commissure & called Anterolateral System –> synapse on Ventral Posterolateral Nucleus VPL of thalamus, tertiary neurons –> Somatosensory Cortex
What type of system is the Anterolateral/Lateral Spinothalamic Tract? What sense does it transmist?
sensory/ascending; exteroception, nociception, crude touch
Define Somatotopical Organization?
most medial is rostral, most lateral is caudal
Deficits of a Peripheral Nerve Lesion.
motor & sensory
Deficits of a Dorsal Root Lesion.
sensory deficits only
Deficits of a Ventral Root Lesions.
motor deficits only
Deficits of a Motor Neuron Lesion of the Ventral Horn.
motor deficits only
Which types of lesions (peripheral, dorsal, ventral, motor neuron of ventral horn) are consistent with Lower Motor Neuron Lesions?
peripheral, ventral, & motor neuron lesion of ventral horn
What are the signs of Lower Motor Neuron Lesion?
Areflexia, Flaccid Paralysis, Muscle Wasting, Fasiculations
In order to damage Lower Motor Neurons, what areas does the lesion occur?
damage to axons in spinal or peripheral nerves
Define Areflexia
absent deep tendon reflexes
Define Flaccid Paralysis
complete loss of muscle tone, & voluntary/reflex movements
Define Fasiculations
spontaneous contractions of motor units
In a Lower Motor Neuron Lesion, signs occur on which side when compared to the damaged neuron?
All signs occur ipsilateral to the lesion AND in muscles supplied by the affected LMN
In an Upper Motor Neuron Lesion, signs occur on which side compared to the damaged neuron?
It depends. If Rostral to pyramidal decussation, CONTRALATERAL signs will mainly be seen (~85% of fibers cross at pyramidal decussation * form the LATERAL corticospinal tract). If Caudal to pyramidal decussation, signs will be IPSILATERAL.
What are the signs of an Upper Motor Neuron Lesion?
Paresis, Spastic Paralysis, Little Muscle Atrophy, Exaggerated Deep-Tendon Reflexes (Hyperreflexia), Babinski Sign
Define Paresis
Muscle weakening – difficulty moving; can lead to paralysis
Define Spastic Paralysis
Spasticity, increased muscle tone, increased resistance to passive stretching
Define Babinski Sign
Abnormal superficial plantar reflex
Dorsal Column Lesion Signs
IPSILATERAL loss of vibration, position, fine touch, & 2 pt discrimination
Lateral Corticospinal Tract Lesion Signs
IPSILATERAL UMN symptoms: Paresis, Spastic Paralysis, Little Muscle Atrophy, Exaggerated Deep-Tendon Reflexes (Hyperreflexia), Babinski Sign
Spinothalamic Tract Lesion Signs
CONTRALATERAL loss of pain, temp sense, crude touch
Spinal Motor Neuron Lesion Signs
IPSILATERAL LMN signs: Areflexia, Flaccid Paralysis, Muscle Wasting, Fasiculations
Autonomic Neuron Lesion Signs
IPSILATERAL miosis, ptsosis, anhydrosis; urinary incontinence; bow incontinence
High Cervical Transection Signs (above/at phrenic n.)
Respiratory Insufficiency, quadriplegia, spinal shock (period of areflexia), autonomic symptoms, spasticity below level of lesion; hyperreflexia (injury to lateral corticospinal tract), bilateral anesthesia (loss of pain/temp sense due to injury of spinothalamic tract), loss of proprioception (injury of dorsal column)
Low Cervical Transection Signs
paraplegia (NOT quadriplegia), Spinal Shock (period of areflexia), Autonomic Symptoms spasticity below level of lesion.
Hyperreflexia (lateral corticospinal tract), bilateral anesthesia (loss of pain/temp sense due to injury of spinothalamic tract), Loss of proprioception (injury of dorsal column)
High Thoracic Transection Signs
Quadriplegia, Spinal Shock (period of areflexia), Autonomic Symptoms spasticity below level of lesion.
Hyperreflexia (lateral corticospinal tract), bilateral anesthesia (loss of pain/temp sense due to injury of spinothalamic tract), Loss of proprioception (injury of dorsal column)
Brown-Sequard Syndrome (spinal cord hemisection)
- Ipsilateral Signs (dorsal column, lateral corticospinal tract, anesthesia at level of lesion [due to damage of primary afferent fibers]).
- Contralateral Signs (spinothalamic tract, beginning 1-2 segments below hemisection).
- Bilateral Signs (segmental loss of pain/them 1-2 segmetns below level of hemisection).
- Ventral Horn Signs (LMN signs by affected spinal cord segments)