08.20 Welch

Question 1

until recently, most drug research was done in..?

Answer 1

males

-women are more sensitive to cardio-toxic effects than men

Question 2

What are the food-drug interactions she mentioned?

Answer 2

• Calcium shouldn’t be taken with tetracyclin
• grapefruit juice and felodipine, the juice increases the levels of felodipine in blood by 40% which is a toxic level
• the juice may inhibit cytochrome P450 enzymes

Question 3

what are the four types of drug tolerance?

Answer 3

• pharmacodynamic (cellular): cells respond to chronic exposure and receptors change, ex-morphine
• metabolic (dispositional): ex: barbiturates
• Behavioral (learned): drugs of abuse, drunks act normal around cops bc they adjust
• Tachyphylaxis (rapid tolerance): nitroglycerine