042915 weakness Flashcards
most common cause of iatrogenic illness in elderly
adverse drug rxns
factors affecting drug response in elderly
reduced total body water reduced lean body mass increased body fat reduced serum albumin decreased creatinine clearance (even within elderly population, though, there's variations creatinine cl) phase I liver metabolism affected
thyrotoxicosis can lead to
osteoporosis (hip fracture in the ex)
how much of body mass is total body water
3/5
how much of TBW is ECF
1/3
how much of ECF is interstitial fluid
3/4
when you see mmole/L solution
convert to mOsm/L to determine osmosis
ECF vs ICF composition
ECF: high in Na, Cl, HCO3
ICF: high in K, PO4, organic anions, protein
hypercalcemia can cause lethargy: true or false
true
how does hepatic blood flow chang ein elderly
decreases
effects of age on hepatic CLEARANCE of some drugs
elderly-phase I is affected (diazepam, flurazepam, etc)
what hypnotics are not metabolized slower in elderly by the liver
lorazepam, oxazepam (phase II metabolism not affected by again)
fever in an elderly pt-differential?
neoplastic
drug
inflammatory (vasculitidies, MI, PE, GI infarct)
infection (UTIs, lower RT infec, pressure ulcers, C diff, norovirus)
if steady state, what parameter of the kidney is constant
urinary excretion of creatinine
frailty syndrome items
shrinking (weight loss more than 10/yr, sarcopenia)
weakness (grip strength)
exhaustion by self report
slowness in walking time
low activity in terms of caloric expenditure
need only 3 of these markers for frailty
