01b: Inflammatory Skin Disease Flashcards
Thickening of the epidermis is referred to as:
Acanthosis
Loss of cell connections in the epidermis is referred to as:
Acantholysis
Fluid pockets forming in epidermis (stretches it out) is a process referred to as:
Spongiosis
Describe the histology of psoriasiform epidermal hyperplasia.
Rete of epidermis extend downward to about the same level
Interface change in which there’s a thick band of leukocytes that extends from base of epidermis, into dermis.
Lichenoid interface change
Parakeratosis refers to:
Abnormality in which nuclei are retained in stratum corneum
Seborrheic dermatitis: what’s the histopathologic process/change?
Subacute spongiosis (in epidermis) with characteristic shoulder parakeratosis (distinctive scaling)
Lichenoid Dermatitis prototype is (X) inflammatory condition, which is characterized by:
X = Lichen Planus
5 P’s: Purple, Pruritic, Polygonal, Planar Papules
Vacuolar Dermatitis, such as in (X) disease, will show which histopathologic changes?
X = lupus
Lymphocytes at interface (of epidermis and dermis) that cause destruction of cells (cleared areas around cells); thickened BM
Lupus band test looks for:
Immune deposits (IgG, A, M, and complement C3)
Pemphigous vulgaris: classic skin finding is (X).
X = flaccid bullae (easily disrupted due to intraepidermal pathology)
Bullous Pemphigoid: classic skin finding is (X).
X = Tense bullae (subepidermal pathology)
Elderly man with round/oval well-demarcated skin lesions that vary from brown/black to gray and can be scraped off.
Seborrheic keratoses
Multiple seborrheic keratoses that erupt at once are associated with which disease? What is the sign called?
Visceral cancer;
Sign of Leser-Trélat
Benign proliferations of epidermis caused by (X) infection. They look like seborrheic keratoses, but on finger.
Verruca Vulgaris
X = HPV (warts)
27 yo patient presents with tan growth on index finger. With magnification, you see multiple small black dots, which you suspect are (X). Diagnosis?
X = thrombosed capillaries
Verruca Vulgaris (HPV wart)
Epidermal inclusion (sebaceous) cyst: (soft/firm), subcutaneous, (mobile/immobile) growth derived from (X).
Firm, mobile;
X = upper portion of hair follicle epithelium (infundibulum)
When suspecting epidermal inclusion cyst, what diagnostic feature should you look for?
Central (blackish) punctum
Over 90% of (X) cysts are located on the scalp. They are (Y)-colored and can be distinguished from epidermal inclusion cysts by:
X = pilar Y = skin
Lack of central punctum
Small white papule on eyelid:
Milia (epidermal inclusion cyst contining keratin)
17 yo female presents with a brown-colored “mole” on leg that she finds painful. On inspection, it’s smooth, dome-shaped papule. What’s the likely diagnosis?
Dermatofibroma
You apply lateral pressure on brown-colored, dome-shaped mole, causing a depression. This is called (X) sign and the skin finding is likely:
X = dimple or Fitzpatrick’s
Dermatofibroma
Papules commonly found grouped on the scrotum and may bleed if traumatized.
Angiokeratomas
Angiokeratomas may be hallmark of which syndrome?
Fabry (alpha galactosidase deficiency)
