01 Basics

Question 1

What characterizes a polarized germinal center?

Answer 1

Polymorphous cells with lots of tingible body macrophages (TBMs) and apoptoses

Question 2

What are the two zones present in germinal centers?

Answer 2

Light (centrocytes) and Dark (centroblasts + TBMs) zones

Question 3

What is the level of mitotic activity in germinal centers?

Answer 3

High mitotic activity

Question 4

What is the BCL-2 status in germinal centers?

Answer 4

Germinal centers usually BCL-2 Positive

Question 5

What translocation is frequently associated with germinal centers?

Answer 5

t(14;18), IGH-BCL2 translocation

Question 6

What distinguishes the appearance of germinal centers with a negative BCL-2?

Answer 6

Monotonous, ayoplaste tycology with few tingible body macrophages and scarce mitotic figures

Question 7

What is Toxoplasma lymphadenitis caused by?

Answer 7

Toxoplasma gondii acquired from feces of cats

Question 8

What are the symptoms of Toxoplasma lymphadenitis?

Answer 8

Acute lymphadenitis +/- fever; can disseminate in immunocompromised

Question 9

What are the key findings in Toxoplasma lymphadenitis?

Answer 9

• Reactive follicles
• Epithelioid histiocytes in loose clusters and encroaching on follicles
• Monocytoid B cells in sinuses