002 Module 2 Part 2

Question 1

acetogenins are from _______1________ and yield compounds like ____2____ and ____3______

Answer 1

1. Acetyl-CoA
2. Fats and
3. polyketides

Question 2

Isoprenoids are from _____1______ which yield compounds like ____2_____and____3____
They could be from _____4____ as well, yielding compounds like _____5______

Answer 2

1. MVA
2. terpenes
3. steroids
4. MEP
5. carotenoids

Question 3

The names of terpene categories if
1. C10
2. C15
3. C20
4. C30

Answer 3

1. Iridoids
2. Sesquiterpenes
3. Diterpenes
4. Steroidal alkaloids

Question 4

Shikimates are from _____1_____ which yield _______2_______

Answer 4

1. Shikimic acid
2. phenylpropanoids

Question 5

aliphatic alkaloids are from ___________

Answer 5

lysine

Question 6

aromatic alkaloids are from _______________

Answer 6

phenylalanine

Question 7

Biosynthesis proceeds by discrete chemically reasonable steps.

Answer 7

-enables us to classify the diversity and complexity of natural products structures
‒ reveals the functional relationships among natural products in a dynamic context
‒ provides essential information which enables us to control or manipulate the formation of desired
metabolites
‒ opens up possible directions in biotechnology and molecular biology through the study of enzymes
(proteomics) and genomics:

Question 8

Genomics + Proteomics + Biosynthesis =

Answer 8

Metabolomics

Question 9

some (5) types of biosynthetic pathways

Answer 9

Simple linear process
Modified linear process
Convergent process
Branching process
Metabolic grid

Question 10

Some Comments on Biosynthetic pathways:

Answer 10

1. obligatory intermediate
2. not always the case
3. widely separated phylogenetically
4. more than one biosynthetic pathway
5. different pathways
6. genetic and environmental factors
7. specific parts or organelles of the plant
8. dynamic flux

Question 11

Major Chemical Transformations in Biosynthesis

Answer 11

1. Hydrolysis
2. Esterification
3. Oxidation
4. Reduction
5. C-C Bond formation
6. Nucleophilic substitution
7. Elimination reaction
8. Cationic rearrangement