غدد Flashcards

1
Q

FBS in pre- diabetes?

A

5.6 (100 mg)- 6.9

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2
Q

In a diabetic patient on Metformin, optimum and target of A1c?

A

Optimum= < 6.5
Target= < 7

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3
Q

Canadian guideline for targets in diabetes (on medication)?
FBS ? PP? Lipid? BP??

A

FBS: 4-7 mmole/ dL
PP: 5-10
Lipid: as moderate to high risk group
BP: 130/80

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4
Q

Canadian guidelines for energy intake in diabetes?

A

for Diet daily carbohydrate intake 45-60% of energy, protein 15-20% of energy and fat ‹35% of energy o intake of saturated fats <7% and polyunsaturated fats ‹10% of total calories each

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5
Q

OGTT in whom?

A

Pre-diabetic + RF

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6
Q

What is the
recommended first-line
medication if HbA1c is ≥8.5% a diabetic patient?

A

Metformin

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7
Q

What is the glucose threshold for gestational diabetes on a glucose challenge test?.

A

≥7.8 mmol/L on a 50g glucose test

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8
Q

How do SGLT2 inhibitors benefit diabetic patients with
heart failure?

A

They lower blood glucose and reduce heart failure risk.

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9
Q

What medication is commonly used to manage gestational diabetes?

A

Glyburide

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10
Q

What is the average
HbA1c reduction achieved
with SGLT2 inhibitors?

A

By 1.5%

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11
Q

What is the main function of GLP-1 analogues in diabetes management?

A

They stimulate insulin secretion and reduce appetite, helping manage diabetes.

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12
Q

When should an OGTT be considered for a pre-diabetic patient?

A

An OGTT is recommended if the patient has additional risk factors

OGTT stands for Oral Glucose Tolerance Test.

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13
Q

What is required for a diabetes diagnosis?

A

Two abnormal tests: fasting glucose ≥7 mmol/L or HbA1c ≥6.5%

These tests confirm the presence of diabetes based on established criteria.

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14
Q

What is the recommended medication for HbA1c ≥8.5% or fasting glucose ≥7 mmol/L?

A

Metformin

Metformin is often the first-line medication for managing elevated blood glucose levels.

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15
Q

What indicates gestational diabetes?

A

Glucose challenge test

This test helps diagnose gestational diabetes during pregnancy.

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16
Q

What are SGLT2 inhibitors effective for?

A

Diabetes and heart failure

SGLT2 inhibitors help lower HbA1c by approximately 1.5%.

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17
Q

Fill in the blank: Regular _______ checks are important for managing pre-diabetes.

A

HbA1c

Monitoring HbA1c levels helps track glucose control over time.

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18
Q

What lifestyle modifications should be advised for pre-diabetic patients?

A

Diet and exercise

These changes can significantly impact glucose levels and overall health.

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19
Q

What does OGTT stand for?

A

Oral Glucose Tolerance Test

OGTT is used to assess how well the body metabolizes glucose.

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20
Q

What are the two components of OGTT?

A

Tolerance and fasting glucose levels

These components help differentiate between normal, impaired, and diabetic ranges.

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21
Q

What is the significance of waist circumference in metabolic syndrome?

A

It helps identify abdominal obesity

Waist circumference is a key measurement for assessing metabolic syndrome risk.

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22
Q

Which medications are commonly discussed for managing diabetes?

A
  • Metformin
  • SGLT2 inhibitors
  • GLP-1 analogs

Each medication has different mechanisms and effects on blood glucose levels.

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23
Q

True or False: Insulin is used for metabolically decompensated patients with pH <7.3.

A

True

Insulin administration is critical in severe metabolic imbalances.

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24
Q

What risks are associated with high HbA1c levels during pregnancy?

A

Congenital abnormalities

High HbA1c can lead to complications for both the mother and fetus.

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25
Q

What are 2 lifestyle modifications in managing pre-diabetes?

A

Dietary advice and avoiding fasting

These modifications can help lower blood glucose and prevent diabetes progression.

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26
Q

Fill in the blank: The first-line treatment for elevated blood glucose levels includes _______.

A

Metformin

Metformin is often prescribed as an initial treatment for diabetes.

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27
Q

What is the classification used in risk stratification?

A

High, moderate, and low-risk groups

Identifying risk levels helps tailor preventive measures and treatment plans.

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28
Q

What are the criteria for diagnosing diabetes?

A
  • Symptoms
  • Random blood sugar levels
  • HbA1c

Multiple criteria are used to ensure accurate diagnosis.

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29
Q

What is the importance of monitoring blood glucose levels?

A

To adjust insulin doses as needed

Regular monitoring is essential for effective diabetes management.

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30
Q

What is the emergency management approach for diabetes?

A

Use of arterial blood gas tests and insulin administration

Recognizing metabolic decompensation is crucial for timely intervention.

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31
Q

What is the main approach to managing pre-diabetes?

A

Lifestyle modifications, including diet and exercise, are the primary approach to managing pre-diabetes.

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32
Q

How frequently should HbA1c be tested in a pre-diabetic patient?

A

HbA1c should be tested more frequently in pre-diabetic patients to monitor progression.

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33
Q

When should an OGTT be considered for a pre-diabetic patient?

A

An OGTT is recommended if a pre-diabetic patient has additional risk factors.

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34
Q

What advice should be given to a patient with impaired fasting glucose (IFG) regarding fasting duration?

A

Patients with IFG should avoid extended fasting periods to prevent glucose spikes.

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35
Q

What is the primary criterion for diagnosing pre-diabetes in a 42-year-old patient with a fasting blood glucose of 6.5 mmol/L?

A

A fasting blood glucose of 6.5 mmol/L meets the threshold for pre-diabetes.

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36
Q

Why are regular HbA1c checks important for pre-diabetes?

A

Regular HbA1c checks help track glucose levels and prevent progression to diabetes.

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37
Q

What are the two main components of an OGTT?

A

The OGTT includes tolerance to glucose intake and fasting glucose levels.

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38
Q

What is the range for impaired glucose tolerance (IGT) in an OGTT?

A

IGT is indicated when glucose levels fall between normal and diabetic thresholds after glucose intake.

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39
Q

What role does the liver play in glucose production during fasting?

A

The liver releases glucose during fasting, affecting blood sugar levels, especially in IFG.

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40
Q

What dietary modifications are recommended for patients with pre-diabetes?

A

A low-carb, low-fat diet is recommended to manage pre-diabetes.

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41
Q

What is metabolic syndrome, and why is it relevant in pre-diabetes?

A

Metabolic syndrome includes risk factors like abdominal obesity and high blood pressure, increasing the risk of diabetes and cardiovascular disease.

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42
Q

What are the diagnostic criteria for diabetes based on fasting glucose?

A

Diabetes is diagnosed if fasting glucose is ≥7 mmol/L.

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43
Q

How many abnormal test results are required to confirm a diabetes diagnosis?

A

Two abnormal results are necessary to confirm a diabetes diagnosis.

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44
Q

What is the recommended first-line medication if HbA1c is ≥8.5% in a diabetic patient?

A

Metformin is recommended as first-line therapy for HbA1c ≥8.5%.

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45
Q

When is insulin indicated for diabetic patients based on pH levels?

A

Insulin is used if the patient is metabolically decompensated with a pH <7.3.

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46
Q

What is the role of long-acting insulin in managing fasting glucose levels?

A

Long-acting insulin helps control liver glucose production, stabilizing fasting glucose.

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47
Q

Why should insulin use be reported to the Ministry of Transport?

A

Reporting is legally required to ensure safe driving due to hypoglycemia risks.

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48
Q

What is the glucose threshold for gestational diabetes on a glucose challenge test?

A

The threshold varies but typically a value ≥7.8 mmol/L on a 50g glucose test indicates gestational diabetes.

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49
Q

What medication is commonly used to manage gestational diabetes?

A

Glyburide is commonly prescribed for managing blood glucose in gestational diabetes.

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50
Q

Why is close monitoring of HbA1c levels important during pregnancy?

A

High HbA1c levels increase risks of congenital abnormalities in the fetus.

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51
Q

What type of specialist should be consulted for managing diabetes during pregnancy?

A

Collaboration with an obstetrician is recommended for managing diabetes during pregnancy.

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52
Q

How do SGLT2 inhibitors benefit diabetic patients with heart failure?

A

SGLT2 inhibitors lower blood glucose and reduce heart failure risk.

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53
Q

What is the average HbA1c reduction achieved with SGLT2 inhibitors?

A

SGLT2 inhibitors can reduce HbA1c by approximately 1.5%.

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54
Q

What is the main function of GLP-1 analogs in diabetes management?

A

GLP-1 analogs stimulate insulin secretion and reduce appetite, helping manage diabetes.

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55
Q

What are the key side effects of Metformin?

A

Common side effects include gastrointestinal symptoms such as nausea and diarrhea.

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56
Q

What is the benefit of combining medications for diabetes management?

A

Combination therapies help achieve optimal glucose control by targeting different pathways.

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57
Q

What dietary advice complements medication therapy in diabetes management?

A

A balanced diet low in processed sugars and fats supports medication efficacy.

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58
Q

How is risk stratification used in diabetes care?

A

Risk stratification identifies high-risk patients for preventive treatments like statins.

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59
Q

What is a key factor in classifying metabolic syndrome related to diabetes risk?

A

Waist circumference is a primary measure, indicating abdominal obesity risk.

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60
Q

What role do the Framingham studies play in diabetes risk assessment?

A

These studies help classify patients into high, moderate, and low-risk groups.

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61
Q

Why is emergency management of diabetes important?

A

Rapid intervention can prevent complications during metabolic decompensation.

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62
Q

What test is used to assess pH and bicarbonate levels in diabetic emergencies?

A

Arterial blood gas (ABG) tests are used to evaluate metabolic decompensation.

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63
Q

Why might a venous blood gas test be used instead of an ABG in emergencies?

A

Venous blood gas can be a less invasive alternative, providing quick pH assessments.

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64
Q

What department is primarily responsible for managing acute diabetes complications?

A

The emergency department handles acute diabetes-related emergencies.

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65
Q

Why is it important to have at least two abnormal glucose tests to diagnose diabetes?

A

Multiple tests ensure accuracy and reduce the likelihood of false positives.

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66
Q

What are the ideal fasting glucose levels for managing diabetes with lifestyle alone?

A

Fasting glucose should ideally be <7 mmol/L for lifestyle-based management.

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67
Q

How often should HbA1c be monitored in diagnosed diabetes?

A

HbA1c should be checked every 3–6 months to monitor diabetes control.

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68
Q

What is the target HbA1c level for most diabetes patients?

A

The target HbA1c is typically <7% to minimize complication risks.

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69
Q

What is the main glucose-lowering effect of SGLT2 inhibitors?

A

They increase glucose excretion in the urine, lowering blood glucose levels.

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70
Q

What precautions are necessary when prescribing SGLT2 inhibitors to heart failure patients?

A

Monitor for signs of dehydration and electrolyte imbalances.

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71
Q

What are the benefits of adding GLP-1 analogs to insulin therapy?

A

They reduce insulin dose requirements and help manage weight.

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72
Q

How does pregnancy affect diabetes management in terms of insulin needs?

A

Insulin requirements often increase due to hormonal changes.

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73
Q

What is the primary action of Metformin in diabetes?

A

Metformin reduces hepatic glucose production, aiding blood sugar control.

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74
Q

When is combination therapy typically considered for diabetes?

A

When lifestyle and single-drug therapy fail to maintain target HbA1c levels.

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75
Q

What monitoring is required for patients on combination therapies?

A

Regular glucose and HbA1c checks are necessary to prevent hypoglycemia.

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76
Q

How can high-risk diabetes patients benefit from statins?

A

Statins lower cardiovascular risk, which is often elevated in diabetes.

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77
Q

What lifestyle changes can help in managing metabolic syndrome?

A

Reducing abdominal obesity through diet and exercise is key.

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78
Q

What is the main goal of emergency diabetes treatment in the ED?

A

Stabilize blood glucose and address any pH or bicarbonate imbalances.

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79
Q

Why is close coordination with specialists recommended for high-risk diabetic patients?

A

Specialized input helps tailor treatment, especially with comorbidities.

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80
Q

What is the risk of untreated gestational diabetes?

A

It can lead to fetal complications, such as macrosomia and hypoglycemia.

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81
Q

What dietary pattern is recommended to help manage diabetes and pre-diabetes?

A

A Mediterranean or low-carb diet is often recommended, as it supports blood sugar control and heart health.

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82
Q

Why is regular monitoring of HbA1c levels important in diabetes management?

A

It allows healthcare providers to assess long-term blood glucose control and adjust treatment if needed.

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83
Q

What effect does Metformin have on the body’s insulin sensitivity?

A

Metformin improves insulin sensitivity, especially in the liver, helping lower blood glucose levels.

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84
Q

How can weight loss impact HbA1c levels in patients with type 2 diabetes?

A

Weight loss generally lowers HbA1c, often resulting in better blood sugar control and possibly reduced medication needs.

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85
Q

What is the primary goal of diabetes management in pregnant women?

A

To maintain blood glucose within target ranges to reduce the risk of complications for both mother and baby.

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86
Q

How does physical activity affect insulin resistance?

A

Exercise increases insulin sensitivity, allowing muscles to better absorb glucose from the bloodstream.

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87
Q

What is the recommended fasting blood glucose range for most diabetes patients?

A

The typical target is 4.4–7.2 mmol/L, though individual goals may vary.

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88
Q

Why are SGLT2 inhibitors beneficial for diabetes patients with heart failure?

A

SGLT2 inhibitors reduce blood sugar, decrease blood pressure, and lower the risk of heart failure hospitalization.

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89
Q

How often should patients with diabetes monitor their blood glucose levels?

A

Frequency depends on treatment, but many are advised to check at least once daily, especially those on insulin.

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90
Q

Why is it important to test both fasting and postprandial (after-meal) glucose levels in diabetes management?

A

Monitoring both helps identify blood sugar trends and manage diabetes more effectively by adjusting diet or medication.

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91
Q

What is the role of continuous glucose monitoring (CGM) in diabetes care?

A

CGM provides real-time blood glucose readings, helping patients and providers make more timely management decisions.

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92
Q

How does stress management contribute to better blood glucose control in diabetes?

A

Reducing stress can lower cortisol levels, which can help decrease blood glucose levels.

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93
Q

Why should patients with diabetes avoid excessive alcohol consumption?

A

Alcohol can cause hypoglycemia, especially in patients taking insulin or certain oral diabetes medications.

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94
Q

What are the primary signs of diabetic neuropathy?

A

Symptoms include numbness, tingling, pain, and weakness, especially in the feet and hands.

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95
Q

How does sleep quality affect blood sugar levels in people with diabetes?

A

Poor sleep can worsen insulin resistance, leading to higher blood glucose levels.

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96
Q

What is the purpose of the glucose challenge test in diagnosing gestational diabetes?

A

The test assesses how well a pregnant woman’s body handles glucose to detect gestational diabetes.

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97
Q

How does high blood pressure affect diabetes complications?

A

High blood pressure can worsen diabetes complications, such as kidney disease and cardiovascular issues.

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98
Q

Why is portion control important for diabetes patients?

A

It helps prevent overeating, which can lead to blood sugar spikes and weight gain.

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99
Q

What is the effect of combining GLP-1 analogs with Metformin in diabetes treatment?

A

Combining these medications often results in better blood glucose control and weight loss.

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100
Q

How can diabetic patients prevent hypoglycemia when exercising?

A

They can monitor blood glucose levels before and after exercise and adjust food intake or insulin doses as needed.

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101
Q

What role does dietary protein play in managing diabetes?

A

Protein helps stabilize blood sugar and can prevent spikes when eaten with carbohydrates.

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102
Q

Why is it important for people with diabetes to regularly monitor cholesterol levels?

A

High cholesterol increases the risk of cardiovascular complications, which are more common in diabetes.

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103
Q

How does fiber intake affect blood sugar levels?

A

Fiber slows down the absorption of sugar, helping to maintain more stable blood glucose levels.

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104
Q

What is the target HbA1c level for most people with type 2 diabetes?

A

The general target is <7%, but this may vary depending on individual health factors.

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105
Q

Why is regular foot examination crucial for diabetes patients?

A

Diabetic neuropathy and poor circulation increase the risk of foot injuries and infections, which can lead to serious complications.

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106
Q

How does a high-salt diet impact diabetes patients?

A

Excessive salt can raise blood pressure, which can worsen diabetes-related complications.

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107
Q

What are the main dietary sources of simple sugars that people with diabetes should limit?

A

Foods high in added sugars, such as sugary drinks, desserts, and candies.

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108
Q

How can a diabetes care team support effective disease management?

A

The team can provide medical, nutritional, and psychological guidance tailored to the patient’s needs.

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109
Q

What are the benefits of GLP-1 receptor agonists for diabetes management?

A

They help lower blood glucose, promote weight loss, and may reduce cardiovascular risk.

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110
Q

What symptoms might indicate high blood sugar in a person with diabetes?

A

Symptoms include frequent urination, increased thirst, blurred vision, and fatigue.

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111
Q

Why is it important for diabetes patients to have regular kidney function tests?

A

Diabetes can damage kidneys, and regular testing can help detect early signs of kidney disease.

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112
Q

How do statins benefit diabetes patients at high risk for cardiovascular disease?

A

Statins lower cholesterol, reducing the risk of heart attack and stroke in diabetes patients.

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113
Q

What role does hydration play in blood glucose management for diabetes patients?

A

Staying hydrated helps kidneys flush out excess glucose and supports better glucose control.

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114
Q

How does aerobic exercise benefit blood glucose levels in diabetes?

A

Aerobic exercise improves insulin sensitivity and can help lower blood sugar.

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115
Q

What is the purpose of diabetes self-management education?

A

It equips patients with knowledge and skills for daily management, including monitoring, diet, and exercise.

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116
Q

Why should diabetes patients avoid trans fats?

A

Trans fats increase the risk of heart disease and worsen insulin resistance.

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117
Q

What is hyperosmolar hyperglycemic state (HHS) and its symptoms?

A

HHS is a severe form of hyperglycemia with symptoms like extreme dehydration, confusion, and high blood sugar.

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118
Q

Why is it important to monitor blood glucose before bed in diabetes?

A

It helps prevent nocturnal hypoglycemia, particularly in patients using insulin.

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119
Q

What are the common side effects of Metformin?

A

Side effects include gastrointestinal issues such as nausea, diarrhea, and stomach discomfort.

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120
Q

How do GLP-1 agonists help with weight loss in diabetes?

A

They decrease appetite and slow gastric emptying, promoting satiety and reducing calorie intake.

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121
Q

What are the symptoms of diabetic ketoacidosis (DKA)?

A

Symptoms include nausea, vomiting, abdominal pain, rapid breathing, and a fruity odor on the breath.

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122
Q

How does regular physical activity benefit blood pressure control in diabetes?

A

It helps lower blood pressure, reducing the risk of complications in diabetes patients.

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123
Q

Why is early detection of pre-diabetes important?

A

Early detection allows for lifestyle changes to prevent or delay the onset of diabetes.

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124
Q

What is the effect of dehydration on blood glucose levels?

A

Dehydration can cause blood glucose to become concentrated, raising blood sugar levels.

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125
Q

Why are combination therapies often used in diabetes management?

A

Combination therapies provide better glucose control by targeting different mechanisms of glucose regulation.

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126
Q

What dietary adjustment is recommended for diabetes patients with kidney disease?

A

Reducing protein intake can help prevent further kidney damage.

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127
Q

Why is it essential to monitor blood glucose levels after meals in diabetes?

A

Post-meal monitoring helps identify how different foods impact blood sugar and manage glucose spikes.

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128
Q

What is the Dawn Phenomenon in diabetes?

A

It is a natural rise in blood sugar in the early morning hours due to hormonal changes.

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129
Q

Why should diabetes patients avoid skipping medications without consulting a doctor?

A

Skipping medications can lead to uncontrolled blood sugar and increase the risk of complications.

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130
Q

How does regular resistance training benefit people with diabetes?

A

Resistance training improves muscle strength, increases insulin sensitivity, and aids in glucose control.

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131
Q

What is the impact of consuming high-glycemic-index foods for someone with diabetes?

A

High-glycemic foods cause rapid spikes in blood sugar, making glucose control more challenging.

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132
Q

Why is meal planning important in diabetes management?

A

Planned meals help maintain consistent blood sugar levels and reduce the risk of glucose spikes.

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133
Q

How do beta cells in the pancreas relate to diabetes?

A

Beta cells produce insulin, and their dysfunction or loss is a key factor in diabetes.

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134
Q

What is the typical duration of action for rapid-acting insulin?

A

Rapid-acting insulin usually works within 15 minutes and lasts 2–4 hours.

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135
Q

How does insulin resistance develop in type 2 diabetes?

A

Cells become less responsive to insulin over time, leading to elevated blood glucose levels.

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136
Q

What is the primary difference between type 1 and type 2 diabetes?

A

Type 1 diabetes is an autoimmune condition with insulin deficiency, while type 2 involves insulin resistance.

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137
Q

Why is carbohydrate counting beneficial for people with diabetes?

A

It helps patients estimate the insulin needed for meals and control blood sugar levels.

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138
Q

What role does the liver play in blood glucose regulation?

A

The liver releases stored glucose, helping maintain normal blood sugar during fasting.

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139
Q

How does high blood sugar affect vision in diabetes patients?

A

It can cause blurry vision and, over time, damage the blood vessels in the retina.

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140
Q

Why are diabetes patients advised to limit saturated fats?

A

Saturated fats can worsen insulin resistance and increase heart disease risk.

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141
Q

What is an insulin pump, and who might benefit from it?

A

An insulin pump is a device for continuous insulin delivery, beneficial for those requiring tight glucose control.

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142
Q

What are ketones, and why are they monitored in diabetes?

A

Ketones are byproducts of fat metabolism, which can accumulate and indicate diabetic ketoacidosis.

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143
Q

Why is it essential to address high cholesterol in diabetes patients?

A

High cholesterol contributes to cardiovascular complications, a common risk in diabetes.

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144
Q

How can fiber in the diet help manage blood sugar levels?

A

Fiber slows sugar absorption, helping to prevent rapid increases in blood glucose.

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145
Q

What are the primary goals of diabetes education programs?

A

To provide knowledge and skills for effective blood sugar management, including diet, exercise, and medication.

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146
Q

How does obesity increase the risk of developing type 2 diabetes?

A

Excess fat contributes to insulin resistance, a key factor in type 2 diabetes development.

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147
Q

What is basal insulin, and when is it used?

A

Basal insulin is long-acting insulin used to control blood sugar between meals and overnight.

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148
Q

What are the potential risks of untreated gestational diabetes?

A

It increases risks for both mother and baby, including high birth weight and future type 2 diabetes.

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149
Q

How does stress impact blood glucose levels?

A

Stress raises cortisol, which can increase blood glucose and make diabetes harder to manage.

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150
Q

What are some common causes of hypoglycemia in diabetes patients?

A

Causes include skipping meals, excessive insulin, increased physical activity, or alcohol consumption.

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151
Q

What is the Somogyi effect in diabetes?

A

It is a rebound hyperglycemia that occurs after a hypoglycemic episode, often overnight.

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152
Q

Why is high blood pressure dangerous for people with diabetes?

A

It increases the risk of kidney disease, heart disease, and stroke.

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153
Q

How often should people with diabetes see an eye specialist?

A

An annual eye exam is recommended to monitor for diabetic retinopathy.

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154
Q

Why is it essential to rotate insulin injection sites?

A

Rotating sites prevents lipodystrophy, which can interfere with insulin absorption.

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155
Q

What is the impact of consuming protein with carbohydrates for blood sugar control?

A

Protein can help slow carbohydrate absorption, leading to a more gradual increase in blood sugar.

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156
Q

Why are foot exams critical for diabetes patients?

A

Diabetes can cause nerve damage and poor circulation, increasing the risk of foot injuries and infections.

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157
Q

What lifestyle changes are often recommended to manage pre-diabetes?

A

Lifestyle changes include a balanced diet, regular exercise, weight management, and reducing sugar intake.

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158
Q

Why is Metformin often the first-line medication for type 2 diabetes?

A

Metformin is effective, has a favorable safety profile, and improves insulin sensitivity.

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159
Q

What is the main difference between rapid-acting and long-acting insulin?

A

Rapid-acting insulin works quickly to manage blood sugar after meals, while long-acting insulin provides steady control.

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160
Q

How does physical activity benefit people with type 2 diabetes?

A

Exercise improves insulin sensitivity, lowers blood glucose, and supports weight management.

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161
Q

What is a diabetic foot ulcer, and why is it a concern?

A

It’s an open sore that can become infected and lead to serious complications if untreated.

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162
Q

Why is it important to avoid smoking in diabetes?

A

Smoking worsens insulin resistance and increases the risk of heart and vascular complications.

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163
Q

What is the purpose of a glycemic target in diabetes care?

A

It provides a blood sugar goal to reduce the risk of complications and improve quality of life.

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164
Q

How does bariatric surgery impact diabetes?

A

It can significantly improve or even resolve type 2 diabetes in some individuals.

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165
Q

Why are postprandial glucose levels monitored in diabetes?

A

Postprandial monitoring helps assess blood sugar response to meals, guiding dietary and medication adjustments.

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166
Q

What is insulin-to-carbohydrate ratio, and why is it used?

A

It’s a personalized calculation to determine insulin needed per carbohydrate gram, helping manage meal-related glucose levels.

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167
Q

Why is protein important in a diabetic diet?

A

Protein has minimal effect on blood glucose and helps maintain satiety and muscle mass.

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168
Q

What symptoms might indicate hypoglycemia in someone with diabetes?

A

Symptoms include sweating, shaking, confusion, and irritability.

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169
Q

Why are combination medications beneficial in diabetes management?

A

They target different aspects of glucose regulation, often achieving better control.

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170
Q

What is gestational diabetes, and how is it diagnosed?

A

It’s high blood sugar during pregnancy, diagnosed with an oral glucose tolerance test.

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171
Q

How does alcohol affect blood glucose levels in people with diabetes?

A

Alcohol can cause hypoglycemia, especially when combined with diabetes medications or on an empty stomach.

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172
Q

What is diabetic retinopathy?

A

It’s a diabetes complication affecting the eyes, caused by damage to the blood vessels in the retina.

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173
Q

Why is it important to eat meals at regular intervals for diabetes?

A

Regular meals help maintain stable blood sugar and prevent large fluctuations.

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174
Q

How do artificial sweeteners impact blood sugar levels?

A

Most artificial sweeteners do not raise blood glucose, making them a low-calorie alternative.

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175
Q

Why should patients with diabetes get vaccinated against the flu?

A

Illnesses like the flu can worsen blood glucose control and lead to complications.

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176
Q

What does an A1c of 8.5% indicate in diabetes?

A

An A1c of 8.5% indicates poor blood sugar control and increased risk of complications.

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177
Q

Why is blood pressure control important in diabetes management?

A

Controlling blood pressure reduces the risk of heart and kidney complications in diabetes patients.

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178
Q

What is the difference between type 1 and type 1.5 diabetes?

A

Type 1.5 diabetes, or LADA, is a slower-progressing autoimmune form of diabetes that may initially be mistaken for type 2.

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179
Q

How does kidney disease affect diabetes management?

A

Kidney disease can affect medication choices and requires careful blood glucose and blood pressure management.

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180
Q

What is the role of omega-3 fatty acids in diabetes management?

A

Omega-3s support heart health, which is especially important in people with diabetes.

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181
Q

What is the purpose of regular dental check-ups for diabetes patients?

A

Diabetes can increase the risk of gum disease, so regular dental care helps maintain oral health.

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182
Q

Why is it important to manage cholesterol levels in diabetes?

A

High cholesterol increases cardiovascular risk, which is already elevated in diabetes.

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183
Q

What is hypoglycemia unawareness?

A

It’s a condition where individuals don’t feel typical low blood sugar symptoms, increasing risk of severe hypoglycemia.

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184
Q

How does a high-fiber diet benefit diabetes patients?

A

High fiber helps slow digestion, stabilize blood sugar, and improve satiety.

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185
Q

Why should diabetes patients limit processed foods?

A

Processed foods often contain added sugars and unhealthy fats, which can worsen blood sugar control.

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186
Q

What is the recommended daily intake of carbohydrates for someone with diabetes?

A

Carbohydrate intake varies by individual needs but is often between 45–60 grams per meal.

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187
Q

How does dehydration affect blood glucose levels in diabetes?

A

Dehydration can cause blood glucose levels to rise due to lower fluid volume in the blood.

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188
Q

What are some high-fiber foods beneficial for diabetes management?

A

Foods such as whole grains, legumes, fruits, and vegetables are rich in fiber and help regulate blood sugar.

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189
Q

Why is protein intake particularly important in diabetic diets?

A

Protein helps stabilize blood sugar levels and can promote satiety, reducing the likelihood of overeating.

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190
Q

What impact does smoking have on blood glucose control?

A

Smoking can increase insulin resistance and exacerbate vascular complications in people with diabetes.

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191
Q

What are the effects of alcohol on blood glucose levels for those with diabetes?

A

Alcohol can cause blood sugar to drop, especially when consumed without food, posing a risk for hypoglycemia.

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192
Q

How does stress management contribute to better diabetes control?

A

Managing stress reduces cortisol levels, which can help lower blood sugar and improve insulin sensitivity.

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193
Q

What is the recommended carbohydrate intake per meal for people with diabetes?

A

Generally, 45-60 grams per meal, depending on individual needs and activity levels.

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194
Q

What are the warning signs of diabetic ketoacidosis (DKA)?

A

Symptoms include excessive thirst, frequent urination, nausea, abdominal pain, and confusion.

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195
Q

How often should HbA1c be monitored in patients with diabetes?

A

Typically every 3-6 months, depending on how well blood sugar is controlled.

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196
Q

What lifestyle modification is recommended to reduce the risk of diabetes complications?

A

Regular physical activity, a balanced diet, smoking cessation, and weight management.

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197
Q

Why is it important for people with diabetes to monitor their feet daily?

A

Daily checks help detect minor injuries or infections early, reducing the risk of severe complications.

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198
Q

What effect does regular exercise have on blood glucose levels?

A

Exercise increases insulin sensitivity, helping muscles absorb glucose and lowering blood sugar levels.

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199
Q

What is the Dawn Phenomenon in diabetes?

A

It’s an early-morning rise in blood sugar due to hormonal changes, often seen in diabetes patients.

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200
Q

How does fiber benefit blood glucose control in diabetes patients?

A

Fiber slows down carbohydrate absorption, helping prevent blood sugar spikes.

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201
Q

What is the difference between hypoglycemia and hyperglycemia?

A

Hypoglycemia is low blood sugar, while hyperglycemia is high blood sugar.

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202
Q

Why should diabetes patients limit their intake of sugary beverages?

A

Sugary drinks cause rapid blood sugar spikes and provide empty calories without nutritional benefits.

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203
Q

What role does the liver play in blood glucose regulation?

A

The liver stores glucose and releases it as needed, helping to maintain stable blood sugar levels.

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204
Q

Why are foot infections dangerous for diabetes patients?

A

Poor circulation and neuropathy can lead to severe infections and delayed healing.

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205
Q

What are ketones, and why are they dangerous in diabetes?

A

Ketones are byproducts of fat metabolism that can accumulate and lead to ketoacidosis if uncontrolled.

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206
Q

How can diabetes increase the risk of heart disease?

A

High blood sugar damages blood vessels and increases cholesterol, raising cardiovascular risk.

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207
Q

What is metabolic syndrome, and how is it related to diabetes?

A

Metabolic syndrome is a group of conditions (high blood pressure, cholesterol, waist circumference) that raise diabetes risk.

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208
Q

How does high blood pressure affect diabetes patients?

A

High blood pressure can worsen kidney damage and increase the risk of cardiovascular events.

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209
Q

Why is it essential for diabetes patients to stay hydrated?

A

Hydration helps kidneys remove excess glucose from the blood and supports overall blood sugar control.

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210
Q

What is the goal of blood sugar management in diabetes?

A

To maintain blood glucose within a target range to prevent complications and promote well-being.

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211
Q

What are the two main types of diabetes?

A

Type 1 diabetes, which is autoimmune, and type 2 diabetes, which is often related to insulin resistance.

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212
Q

What is the primary function of insulin in the body?

A

Insulin helps cells absorb glucose from the blood to be used for energy.

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213
Q

Why is protein important in a diabetes diet?

A

Protein helps slow carbohydrate digestion and prevents rapid blood sugar increases.

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214
Q

What is the purpose of an HbA1c test in diabetes management?

A

HbA1c measures average blood glucose over 2-3 months, indicating overall glucose control.

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215
Q

Why is it important for people with diabetes to avoid processed foods?

A

Processed foods often contain hidden sugars and unhealthy fats that can worsen blood glucose control.

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216
Q

What effect does caffeine have on blood glucose?

A

Caffeine may raise blood glucose levels in some people by increasing adrenaline.

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217
Q

What is the purpose of the Oral Glucose Tolerance Test (OGTT)?

A

The OGTT helps diagnose diabetes and pre-diabetes by measuring glucose response after drinking a sugary solution.

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218
Q

What are common symptoms of diabetes?

A

Symptoms include excessive thirst, frequent urination, fatigue, blurred vision, and slow wound healing.

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219
Q

Why is it crucial for diabetes patients to manage cholesterol levels?

A

High cholesterol can exacerbate the risk of cardiovascular complications associated with diabetes.

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220
Q

What is basal insulin?

A

Basal insulin is long-acting insulin that maintains steady glucose levels between meals.

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221
Q

How does high blood glucose affect kidney function in diabetes?

A

Chronic high glucose damages kidney blood vessels, leading to diabetic nephropathy.

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222
Q

What are GLP-1 receptor agonists, and how do they help in diabetes management?

A

GLP-1 agonists increase insulin secretion and reduce appetite, aiding in glucose control and weight loss.

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223
Q

Why is regular blood sugar monitoring essential in diabetes?

A

It helps patients understand their glucose trends and adjust their treatment as needed.

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224
Q

How does high blood sugar damage nerves in diabetes?

A

Prolonged high glucose damages the nerve’s blood supply, leading to neuropathy.

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225
Q

What is the primary cause of type 1 diabetes?

A

An autoimmune attack on insulin-producing beta cells in the pancreas.

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226
Q

How can losing weight improve blood sugar control in type 2 diabetes?

A

Weight loss reduces insulin resistance, helping lower blood glucose levels.

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227
Q

What is the main treatment goal for gestational diabetes?

A

To control blood sugar levels and minimize risks for both mother and baby.

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228
Q

What role does the pancreas play in diabetes?

A

The pancreas produces insulin, which regulates blood sugar levels.

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229
Q

How does Metformin work in managing diabetes?

A

Metformin lowers blood glucose by reducing liver glucose production and improving insulin sensitivity.

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230
Q

What is diabetic retinopathy?

A

It’s an eye condition caused by damage to blood vessels in the retina due to high blood sugar.

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231
Q

How can managing stress benefit blood glucose control?

A

Lowering stress can reduce cortisol levels, leading to better glucose regulation.

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232
Q

Why is it important for people with diabetes to maintain a healthy weight?

A

Healthy weight reduces insulin resistance and lowers the risk of complications.

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233
Q

What are the common side effects of Metformin?

A

Common side effects include gastrointestinal issues like nausea and diarrhea.

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234
Q

Why is it important to rotate insulin injection sites?

A

Rotating sites prevents skin complications and ensures consistent insulin absorption.

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235
Q

How does exercise help lower blood glucose levels in diabetes?

A

Exercise increases insulin sensitivity and helps muscles use glucose for energy.

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236
Q

What are the benefits of combining medications in diabetes treatment?

A

Combination therapy can address different aspects of blood glucose regulation more effectively.

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237
Q

Why is it important for diabetes patients to have regular check-ups?

A

Regular check-ups help monitor blood glucose, check for complications, and adjust treatment plans.

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238
Q

What is insulin resistance?

A

It’s when cells do not respond effectively to insulin, leading to high blood sugar.

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239
Q

How does the HbA1c test differ from a blood glucose test?

A

HbA1c reflects average blood glucose over months, while a blood glucose test gives a single-time result.

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240
Q

What is diabetic nephropathy?

A

Kidney damage caused by high blood glucose.

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241
Q

Why is blood pressure control important in diabetes management?

A

High blood pressure can exacerbate kidney and cardiovascular complications in diabetes.

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242
Q

What is the ‘Rule of 15’ for treating hypoglycemia?

A

If blood sugar is low, consume 15 grams of carbs, wait 15 minutes, and recheck blood sugar.

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243
Q

What is insulin stacking, and why is it dangerous?

A

Insulin stacking is taking additional doses before previous insulin has fully absorbed, risking hypoglycemia.

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244
Q

How does diabetes increase the risk of infections?

A

High glucose impairs immune response, making it harder to fight infections.

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245
Q

What is the role of carbohydrates in diabetes management?

A

Carbs impact blood sugar the most, so counting and timing intake helps control glucose levels.

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246
Q

Why is foot care critical for people with diabetes?

A

Neuropathy can prevent them from feeling injuries, which can lead to infections and ulcers.

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247
Q

What does an insulin pump do?

A

It delivers insulin continuously and can be programmed to match individual blood sugar patterns.

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248
Q

What dietary pattern is often recommended for type 2 diabetes?

A

A balanced diet with controlled portions of carbohydrates, fiber, protein, and healthy fats.

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249
Q

What is a major risk factor for type 2 diabetes?

A

Obesity, as excess body fat increases insulin resistance.

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250
Q

How does sleep impact blood sugar levels?

A

Poor sleep can raise blood sugar by increasing insulin resistance and stress hormones.

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251
Q

What are ketones, and why are they monitored in diabetes?

A

Ketones are produced when fat is used for energy instead of glucose; high levels can indicate ketoacidosis.

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252
Q

What is lipohypertrophy, and how does it relate to insulin use?

A

It’s a thickening of skin from repeated injections at the same site, affecting insulin absorption.

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253
Q

How does Metformin affect glucose production?

A

It decreases glucose production in the liver, helping lower blood glucose.

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254
Q

What is basal-bolus insulin therapy?

A

A regimen combining long-acting (basal) and short-acting (bolus) insulin to manage blood glucose.

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255
Q

Why should people with diabetes limit saturated fats?

A

They can increase cholesterol, raising the risk of heart disease, which is already higher in diabetes.

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256
Q

What is a low glycemic index (GI) food, and why is it beneficial in diabetes?

A

Low GI foods cause slower blood sugar rises, helping manage glucose levels.

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257
Q

How does resistance training help manage diabetes?

A

It builds muscle, which increases insulin sensitivity and helps control blood sugar.

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258
Q

What is the goal of diabetes management in pregnancy?

A

To maintain blood glucose levels to avoid complications for both mother and baby.

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259
Q

How often should people with diabetes test their blood glucose?

A

Frequency varies; some may test multiple times daily, while others check less often based on their treatment plan.

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260
Q

What is the Somogyi effect?

A

It’s a rebound high blood sugar following low blood sugar, often due to excess insulin at night.

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261
Q

Why are regular eye exams recommended for people with diabetes?

A

To detect early signs of diabetic retinopathy and prevent vision loss.

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262
Q

What are some common symptoms of hypoglycemia?

A

Symptoms include shakiness, sweating, confusion, and, in severe cases, unconsciousness.

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263
Q

What impact does smoking cessation have on diabetes management?

A

Quitting smoking improves blood vessel health, reducing the risk of complications.

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264
Q

How does stress influence blood sugar in diabetes?

A

Stress raises cortisol, which can increase blood sugar and worsen glucose control.

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265
Q

What is insulin resistance, and how does it affect diabetes?

A

It’s when cells don’t respond well to insulin, making it hard to lower blood sugar levels.

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266
Q

Why is it essential to have a consistent meal schedule in diabetes management?

A

Consistent meals help maintain stable blood glucose levels throughout the day.

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267
Q

How does alcohol affect blood glucose levels?

A

It can cause hypoglycemia, especially when consumed without food, as the liver prioritizes processing alcohol over glucose production.

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268
Q

What is the significance of triglyceride levels in diabetes?

A

High triglycerides often accompany diabetes and increase cardiovascular risk.

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269
Q

Why is the waist-to-hip ratio relevant in assessing diabetes risk?

A

A higher ratio indicates central obesity, which is linked to insulin resistance.

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270
Q

What is hyperosmolar hyperglycemic state (HHS)?

A

A severe complication of diabetes with very high blood glucose, often without ketosis, leading to dehydration and confusion.

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271
Q

How does fiber benefit blood glucose control?

A

Fiber slows digestion, helping prevent rapid spikes in blood sugar.

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272
Q

What is the primary goal of medical nutrition therapy in diabetes?

A

To manage blood glucose, cholesterol, and blood pressure through a balanced diet.

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273
Q

Why is hydration particularly important for diabetes patients?

A

Proper hydration helps flush out excess blood sugar through urine.

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274
Q

What is the ‘dawn phenomenon,’ and how does it affect blood sugar?

A

It’s an early morning rise in blood glucose due to hormone changes, often requiring medication adjustments.

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275
Q

How do GLP-1 receptor agonists assist in type 2 diabetes management?

A

They stimulate insulin release, reduce appetite, and slow stomach emptying to lower blood sugar.

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276
Q

Why is insulin important for managing type 1 diabetes?

A

Type 1 diabetes patients lack insulin production, so it must be provided externally.

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277
Q

What is diabetic ketoacidosis (DKA)?

A

A serious complication where lack of insulin leads to high blood glucose and ketones, causing acidosis.

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278
Q

How does regular physical activity help manage diabetes?

A

It improves insulin sensitivity and helps control blood glucose.

279
Q

Why are blood lipids monitored in diabetes patients?

A

Diabetes increases the risk of high cholesterol, which can contribute to cardiovascular disease.

280
Q

What is the benefit of counting carbohydrates in diabetes?

A

It helps manage post-meal blood sugar by controlling carbohydrate intake.

281
Q

What is an insulin pen, and how is it used?

A

It’s a device for injecting insulin that allows for easier and more accurate dosing.

282
Q

Why is foot care education critical for people with diabetes?

A

Foot care education helps prevent complications from injuries that may go unnoticed due to neuropathy.

283
Q

What does improved insulin sensitivity do?

A

It helps control blood glucose.

284
Q

Why is foot care education critical for people with diabetes?

A

Neuropathy and poor circulation increase the risk of severe foot complications, requiring preventive care.

285
Q

How can weight loss help prevent type 2 diabetes in at-risk individuals?

A

Weight loss reduces insulin resistance, which can lower the risk of developing diabetes.

286
Q

What are ‘free foods’ in diabetes management?

A

Foods low in carbs and calories that don’t significantly affect blood glucose, like certain vegetables.

287
Q

What is the first step in managing a patient with diabetic ketoacidosis (DKA)?

A

The first step is initial fluid resuscitation with normal saline due to severe dehydration.

288
Q

Why should potassium not be added to the initial IV fluid in DKA management?

A

Potassium is not added initially because potassium levels need to be assessed and monitored first to avoid hyperkalemia.

289
Q

What is the recommended insulin dose for DKA management?

A

The recommended insulin dose for DKA is 0.1 units/kg/hour.

290
Q

Which markers should be closely monitored during DKA management?

A

Serum glucose, potassium, bicarbonate, and anion gap should be monitored closely.

291
Q

At what blood glucose range should DKA treatment aim to maintain levels?

A

Blood glucose should be maintained between 130 and 160 mg/dL to avoid complications like cerebral edema.

292
Q

What is the importance of monitoring anion gap in DKA?

A

Monitoring the anion gap helps determine if acidosis is resolving and guides adjustments in treatment.

293
Q

In the absence of volume overload, should diuretics be used in DKA management?

A

No, diuretics should generally be avoided as kidneys can excrete chloride effectively unless there is volume overload.

294
Q

What clinical features are common in diabetic ketoacidosis?

A

Common features include polyuria, polydipsia, polyphagia, fatigue, nausea, vomiting, and orthostatic changes.

295
Q

What role does insulin play in decreasing serum potassium during DKA treatment?

A

Insulin promotes potassium uptake by cells, which can lead to hypokalemia if not monitored.

296
Q

What should be monitored closely when transitioning from IV to subcutaneous insulin in DKA?

A

Blood glucose, ketone levels, and anion gap should be stable to avoid rebound hyperglycemia or ketoacidosis.

297
Q

Why is bicarbonate generally avoided in DKA management?

A

Bicarbonate can increase risk of hypokalemia and paradoxical CNS acidosis.

298
Q

What indicates the need to restart insulin therapy if hyperglycemia returns after DKA resolution?

A

An increase in blood glucose above 250 mg/dL with symptoms or lab signs of acidosis may indicate relapse.

299
Q

What is the initial target blood glucose level in HHS treatment?

A

Blood glucose should be gradually lowered to around 250–300 mg/dL initially to prevent rapid shifts.

300
Q

What potential cardiovascular complication is a concern in HHS due to hyperviscosity?

A

The risk of thromboembolism is higher in HHS due to blood hyperviscosity.

301
Q

What mental status changes are associated with severe DKA and HHS?

A

Confusion, lethargy, and coma can occur due to hyperosmolarity or acidosis.

302
Q

Why might DKA patients present with tachycardia?

A

Dehydration and acidosis stimulate the sympathetic nervous system, leading to tachycardia.

303
Q

How can AKI (acute kidney injury) complicate DKA management?

A

AKI impairs the kidneys’ ability to clear glucose and ketones, worsening hyperglycemia and acidosis.

304
Q

What clinical signs suggest fluid overload during DKA treatment?

A

Peripheral edema, jugular venous distension, and crackles in the lungs indicate fluid overload.

305
Q

Why is frequent electrolyte monitoring essential in DKA?

A

Rapid shifts in potassium and other electrolytes can cause dangerous imbalances during treatment.

306
Q

How is polyuria in DKA related to hyperglycemia?

A

High glucose levels exceed renal glucose reabsorption, leading to glucose in urine and osmotic diuresis.

307
Q

What is the target serum potassium level to maintain during DKA treatment?

A

A serum potassium level between 4.0-5.0 mEq/L is ideal to avoid hypokalemia.

308
Q

What other electrolyte besides potassium should be monitored closely due to insulin’s effects?

A

Magnesium should be monitored, as insulin may cause it to shift into cells, risking hypomagnesemia.

309
Q

When is phosphate supplementation considered in DKA management?

A

Phosphate supplementation may be needed if levels drop significantly or if there’s respiratory muscle weakness.

310
Q

What respiratory pattern is commonly seen in severe DKA?

A

Kussmaul respirations, a deep and labored breathing pattern, are a common compensatory response.

311
Q

What is the typical pH range indicating severe acidosis in DKA?

A

A pH below 7.0–7.2 indicates severe acidosis in DKA cases.

312
Q

Why should subcutaneous insulin be started before discontinuing IV insulin in DKA?

A

This ensures insulin levels remain stable to prevent rebound ketoacidosis.

313
Q

How does hypoglycemia risk increase as DKA treatment progresses?

A

As glucose is lowered, failure to add dextrose to IV fluids can lead to hypoglycemia.

314
Q

What complication is particularly associated with rapid fluid and electrolyte shifts in HHS?

A

Cerebral edema can occur due to rapid osmotic changes during rehydration.

315
Q

Why is fever monitoring important in patients with DKA?

A

Fever can indicate underlying infection, a common precipitant of DKA.

316
Q

How does untreated infection worsen DKA?

A

Infection triggers stress hormones like cortisol and epinephrine, worsening hyperglycemia and ketogenesis.

317
Q

Why is DKA often associated with elevated serum lactate?

A

Severe dehydration can reduce tissue perfusion, leading to anaerobic metabolism and lactate production.

318
Q

What is the significance of abdominal pain in DKA?

A

Abdominal pain may be due to acidosis or, rarely, pancreatitis as a complication of DKA.

319
Q

How does elevated anion gap help in diagnosing DKA?

A

An elevated anion gap indicates metabolic acidosis, typical of DKA due to ketone production.

320
Q

What’s the role of hyperventilation in DKA?

A

Hyperventilation helps compensate for metabolic acidosis by expelling CO2.

321
Q

How does nausea and vomiting affect DKA patients?

A

Nausea and vomiting exacerbate dehydration and electrolyte imbalances in DKA.

322
Q

What role does cortisol play in the pathophysiology of DKA?

A

Cortisol promotes gluconeogenesis and lipolysis, contributing to hyperglycemia and ketogenesis.

323
Q

When is insulin infusion discontinued in DKA?

A

When blood glucose is stable, the anion gap is closed, and the patient is ready for subcutaneous insulin.

324
Q

Why should insulin be titrated carefully in HHS patients?

A

Insulin should be adjusted to avoid rapid glucose shifts, preventing osmotic complications.

325
Q

What laboratory marker helps to track renal recovery in HHS patients?

A

A decrease in BUN and creatinine with treatment indicates improved renal function.

326
Q

What initial IV fluid is recommended for HHS?

A

Normal saline is recommended initially to restore intravascular volume in HHS patients.

327
Q

What is the general mortality rate for DKA if untreated?

A

Untreated DKA has a mortality rate of up to 5–10%, which increases with delayed intervention.

328
Q

Why does DKA cause fatigue and weakness?

A

Cellular glucose deprivation due to insulin deficiency results in energy depletion and weakness.

329
Q

What is the risk of over-correction of acidosis in DKA?

A

Over-correction can cause metabolic alkalosis, leading to electrolyte disturbances.

330
Q

How does polyphagia (increased appetite) present in DKA?

A

Despite high blood glucose, cells are starved of glucose, leading to increased appetite.

331
Q

What is the main clinical sign of hydration improvement in DKA?

A

Increased urine output and normalized vital signs indicate improved hydration.

332
Q

How does stress affect insulin requirements in hospitalized DKA patients?

A

Stress increases cortisol and epinephrine, often requiring higher insulin doses.

333
Q

Why should close monitoring continue even after DKA resolution?

A

Relapse can occur if underlying issues (e.g., infection, missed insulin) are not addressed.

334
Q

Why is glucose monitoring essential for preventing DKA relapse post-discharge?

A

Frequent monitoring helps ensure insulin dosing is effective and glucose remains stable.

335
Q

What imaging study may be considered in DKA patients presenting with abdominal pain?

A

An abdominal CT scan can rule out pancreatitis or other acute abdominal conditions.

336
Q

Why is bicarbonate therapy controversial in DKA management?

A

Bicarbonate can worsen hypokalemia and has been associated with an increased risk of cerebral edema in children.

337
Q

How does hyperglycemia-induced osmotic diuresis affect electrolytes in DKA?

A

It leads to significant loss of sodium, potassium, and chloride in the urine.

338
Q

What is the primary cause of acidosis in DKA?

A

Accumulation of ketone bodies (beta-hydroxybutyrate and acetoacetate) due to lack of insulin.

339
Q

Why should patients with DKA be monitored for signs of sepsis?

A

Infection is a common precipitating factor for DKA, and sepsis can complicate recovery.

340
Q

How does dehydration in HHS compare to that in DKA?

A

Dehydration in HHS is typically more severe and prolonged, often requiring cautious fluid resuscitation.

341
Q

Why is a slow correction of hyperglycemia recommended in HHS?

A

Rapid correction can lead to cerebral edema due to sudden changes in serum osmolality.

342
Q

How is hypernatremia managed in HHS?

A

Hypernatremia is managed with gradual fluid replacement using hypotonic solutions if needed.

343
Q

Why is it essential to calculate corrected serum sodium in hyperglycemic patients?

A

Corrected sodium provides a true indication of sodium levels in the presence of hyperglycemia.

344
Q

What is the most common electrolyte disturbance in DKA?

A

Hypokalemia is common due to insulin therapy and osmotic diuresis.

345
Q

Why are elderly patients at higher risk of HHS?

A

Age-related renal impairment and decreased thirst response increase the risk of severe dehydration.

346
Q

What are the main goals of DKA management?

A

Goals include correcting dehydration, electrolyte imbalances, hyperglycemia, and acidosis.

347
Q

How does stress hyperglycemia contribute to DKA?

A

Stress hormones like cortisol increase blood glucose, exacerbating hyperglycemia in insulin deficiency.

348
Q

When can patients with DKA transition from IV to subcutaneous insulin?

A

Transition is appropriate once the anion gap has closed, and blood glucose is stable.

349
Q

Why is frequent monitoring of blood glucose necessary during DKA treatment?

A

To avoid rapid drops in glucose that can lead to hypoglycemia and cerebral edema.

350
Q

What does a high WBC count in DKA patients indicate?

A

It may suggest an underlying infection or be a response to stress; further evaluation is needed.

351
Q

How is volume status assessed in DKA patients?

A

Volume status can be assessed by monitoring vital signs, skin turgor, urine output, and blood pressure.

352
Q

Why is close monitoring of urine output important in HHS?

A

It provides insights into hydration status and kidney function, critical in managing HHS.

353
Q

Why is cerebral edema a higher risk in children with DKA?

A

Children have a lower tolerance for osmotic shifts and fluid changes, increasing their risk of cerebral edema.

354
Q

How does prolonged hyperglycemia affect brain cells in HHS?

A

Chronic hyperglycemia increases blood osmolarity, causing water to shift out of brain cells, leading to dehydration of brain tissue.

355
Q

How is hypokalemia prevented during DKA treatment?

A

Potassium is added to IV fluids once levels drop below 5.3 mEq/L to avoid hypokalemia.

356
Q

What neurological signs may indicate cerebral edema in DKA?

A

Headache, confusion, altered mental status, and papilledema can signal cerebral edema.

357
Q

What is a hallmark symptom of HHS not commonly seen in DKA?

A

Severe neurological impairment, including seizures or coma, is more common in HHS.

358
Q

Why is continuous ECG monitoring sometimes used in DKA treatment?

A

ECG monitoring helps detect arrhythmias due to electrolyte imbalances, particularly potassium changes.

359
Q

How does insulin deficiency contribute to ketone production in DKA?

A

Insulin deficiency leads to unrestrained lipolysis, resulting in free fatty acids converted to ketones.

360
Q

How is the anion gap used in monitoring DKA?

A

The anion gap helps track resolution of ketoacidosis, with closure indicating improvement.

361
Q

Why might beta-hydroxybutyrate levels be checked in DKA?

A

It is the main ketone body in DKA and provides a more accurate measure of ketosis.

362
Q

Why does HHS have a higher mortality rate than DKA?

A

HHS patients are often older, with more comorbidities, and face greater risks from severe dehydration and hyperosmolarity.

363
Q

What is the role of dextrose in IV fluids during DKA treatment?

A

Dextrose is added when blood glucose falls to prevent hypoglycemia and ensure safe insulin continuation.

364
Q

What is osmotic diuresis, and why does it occur in DKA?

A

Osmotic diuresis is the increased urine output due to high blood glucose, which pulls water into the urine.

365
Q

How does hyperosmolality contribute to neurological symptoms in HHS?

A

Hyperosmolality causes fluid shifts out of brain cells, leading to neurological symptoms such as confusion.

366
Q

What factors influence the fluid resuscitation rate in HHS?

A

Factors include the degree of dehydration, electrolyte status, renal function, and cardiac status.

367
Q

Why is bicarbonate only given in severe DKA cases?

A

Bicarbonate may worsen acidosis through shifts in CO2 and is generally reserved for severe acidosis.

368
Q

How is serum ketone measurement helpful in managing DKA?

A

It helps assess the degree of ketosis and monitor response to therapy.

369
Q

Why might HHS patients be more prone to thrombosis?

A

Hyperosmolarity increases blood viscosity, raising the risk of thrombosis.

370
Q

How do you differentiate between mild and severe DKA?

A

Severity is based on pH, bicarbonate levels, and mental status, with severe cases having pH < 7.0.

371
Q

What are the first signs of effective DKA treatment?

A

Improved mental status, decreased anion gap, and better hydration are signs of effective treatment.

372
Q

How does cortisol influence DKA pathophysiology?

A

Cortisol promotes gluconeogenesis, increasing blood glucose and contributing to DKA.

373
Q

Why should a diabetic patient avoid missing insulin doses?

A

Missed doses can lead to insulin deficiency, triggering ketosis and potentially leading to DKA.

374
Q

Why does polyuria occur in both DKA and HHS?

A

Elevated glucose levels lead to osmotic diuresis, causing excessive urination and fluid loss.

375
Q

How does severe dehydration in HHS impact kidney function?

A

Dehydration reduces renal blood flow, impairing kidney function and potentially leading to acute kidney injury.

376
Q

What changes in breathing patterns occur with DKA?

A

Kussmaul breathing, or deep and rapid breaths, occurs as a compensatory response to acidosis.

377
Q

How does hypovolemia in DKA affect heart rate?

A

Hypovolemia leads to tachycardia as the body attempts to maintain blood pressure.

378
Q

Why might insulin requirements be higher in patients with infection-induced DKA?

A

Infection raises stress hormones that increase insulin resistance, necessitating higher insulin doses.

379
Q

What physical sign might indicate dehydration in a DKA or HHS patient?

A

Dry mucous membranes and poor skin turgor indicate dehydration.

380
Q

What clinical scenario often triggers HHS?

A

HHS is often triggered by infections, myocardial infarctions, or stroke in patients with type 2 diabetes.

381
Q

What role does patient education play post-DKA or HHS?

A

Education on insulin administration, glucose monitoring, and recognizing symptoms can prevent recurrence.

382
Q

Why is fluid administration slower in HHS compared to DKA?

A

Gradual rehydration is essential in HHS to avoid fluid overload and minimize neurological risks.

383
Q

Why is frequent reassessment critical in DKA/HHS management?

A

Continuous monitoring helps adjust therapy to prevent complications like hypoglycemia and cerebral edema.

384
Q

How can the risk of recurrent DKA be minimized?

A

Adherence to insulin therapy, regular glucose monitoring, and managing precipitating factors reduce the risk.

385
Q

What is the goal in managing blood glucose levels in DKA to prevent cerebral edema?

A

The goal is to avoid rapid blood glucose level drops and maintain gradual correction.

386
Q

How does the management of non-ketotic hyperosmolar state (NKHS) differ from DKA?

A

NKHS management involves a slower rate of fluid administration due to its chronic nature and potential comorbidities.

387
Q

Which patients are more likely to experience NKHS?

A

NKHS is more common in type 2 diabetics.

388
Q

What is the focus of fluid administration in NKHS management?

A

The focus is on rehydration, but with a slower approach compared to DKA due to the risk of overloading in chronic cases.

389
Q

How should insulin therapy be adjusted in NKHS management?

A

Insulin is typically adjusted based on blood glucose levels using a sliding scale.

390
Q

What is the mortality rate for diabetic ketoacidosis?

A

The mortality rate for DKA is around 5%.

391
Q

What is the mortality rate for non-ketotic hyperosmolar state (NKHS)?

A

The mortality rate for NKHS is higher, around 50%, often due to underlying comorbidities and age.

392
Q

Why is gradual correction important in DKA and NKHS management?

A

Gradual correction helps prevent complications like cerebral edema and electrolyte imbalance.

393
Q

Which complications are managed with statins in diabetes?

A

Statins are used to manage macrovascular complications, such as coronary artery disease, by controlling lipid levels.

394
Q

What are the primary microvascular complications of diabetes?

A

Microvascular complications include retinopathy, nephropathy, and peripheral neuropathy.

395
Q

What LDL level target is recommended to prevent macrovascular complications in diabetes?

A

The target LDL level is less than 70 mg/dL.

396
Q

Why is monitoring urinary output important in DKA management?

A

Urinary output indicates kidney function and helps assess hydration status and renal response to therapy.

397
Q

Why is it crucial to monitor potassium levels in both DKA and NKHS?

A

Potassium levels fluctuate with insulin and fluid therapy; monitoring helps prevent hypokalemia or hyperkalemia.

398
Q

How does insulin therapy affect potassium levels in DKA?

A

Insulin shifts potassium into cells, which can decrease serum potassium levels, necessitating careful monitoring and replacement if needed.

399
Q

What role does bicarbonate play in DKA management?

A

Bicarbonate is monitored as it reflects acid-base status and helps assess the resolution of metabolic acidosis.

400
Q

When is bicarbonate replacement considered in DKA?

A

Bicarbonate replacement is considered only in severe cases with a pH < 6.9 due to potential risks of rapid correction.

401
Q

What is the significance of a high anion gap in DKA?

A

A high anion gap indicates ongoing metabolic acidosis, which requires continued management with fluids and insulin.

402
Q

At what glucose level should the insulin infusion rate be reduced in DKA?

A

Insulin infusion rate is typically reduced when blood glucose approaches 200-250 mg/dL to prevent hypoglycemia.

403
Q

Why is cerebral edema a risk in DKA and NKHS?

A

Rapid shifts in osmolarity due to aggressive fluid or glucose management can cause brain swelling, especially in young patients.

404
Q

What factors increase the risk of cerebral edema in DKA patients?

A

Rapid correction of blood glucose, high initial glucose levels, and young age increase cerebral edema risk.

405
Q

How is hydration assessed during DKA management?

A

Hydration is assessed through clinical signs (e.g., skin turgor, blood pressure) and urine output monitoring.

406
Q

Why is a slower fluid administration approach used in NKHS?

A

NKHS patients are often elderly with comorbidities, so a slower approach reduces the risk of fluid overload and heart failure.

407
Q

What are typical serum osmolarity levels in NKHS?

A

Serum osmolarity in NKHS is often above 320 mOsm/kg, indicating significant hyperosmolarity.

408
Q

What initial laboratory tests are essential in evaluating DKA and NKHS?

A

Blood glucose, electrolyte panel, BUN, creatinine, serum osmolarity, and arterial blood gas (ABG) are critical initial tests.

409
Q

How often should blood glucose be monitored in DKA?

A

Blood glucose should be monitored hourly initially to guide insulin therapy adjustments.

410
Q

What is the goal of anion gap closure in DKA management?

A

The goal is to reach an anion gap within the normal range, indicating resolution of metabolic acidosis.

411
Q

Why might urinary ketones persist even after clinical resolution of DKA?

A

Urinary ketones lag behind serum ketone clearance and may remain positive despite metabolic recovery.

412
Q

What is the primary cause of NKHS in type 2 diabetes?

A

NKHS is often precipitated by infections, dehydration, or stress in patients with poorly controlled type 2 diabetes.

413
Q

How does infection influence the management of DKA or NKHS?

A

Infections can worsen hyperglycemia and dehydration, so they must be identified and treated concurrently.

414
Q

Why are antibiotics often considered in DKA or NKHS patients?

A

Infection is a common precipitant, so empiric antibiotics may be started if an infection is suspected.

415
Q

How does severe dehydration present in NKHS?

A

Severe dehydration in NKHS may present as dry mucous membranes, tachycardia, hypotension, and altered mental status.

416
Q

What is a major complication associated with severe NKHS?

A

Thromboembolic events, such as deep vein thrombosis (DVT), are common due to high blood viscosity from dehydration.

417
Q

Why is the goal glucose level lower in NKHS than in DKA?

A

Since NKHS patients are not ketotic, glucose reduction should be more gradual to avoid osmotic shifts.

418
Q

When should insulin therapy be paused in DKA treatment?

A

Insulin may be paused if potassium falls below 3.3 mmol/L, as hypokalemia can cause dangerous cardiac arrhythmias.

419
Q

What are common electrolyte abnormalities in DKA?

A

DKA often presents with hyperkalemia initially, followed by hypokalemia as insulin shifts potassium into cells.

420
Q

Why should glucose be added to IV fluids as DKA resolves?

A

Adding glucose prevents hypoglycemia as insulin is continued to clear ketones and close the anion gap.

421
Q

What mental status changes may indicate progression to NKHS?

A

Confusion, lethargy, and even coma can occur in NKHS due to hyperosmolarity and dehydration.

422
Q

What is the purpose of ABG testing in DKA?

A

ABG testing helps evaluate acid-base status and severity of acidosis, which guides treatment adjustments.

423
Q

Why is gradual reduction of blood glucose crucial in DKA/NKHS management?

A

A gradual reduction prevents osmotic shifts that could lead to cerebral edema, especially in children.

424
Q

What urine output level indicates adequate renal function during DKA treatment?

A

A urine output of at least 0.5-1 mL/kg/hr suggests adequate renal perfusion and response to fluid therapy.

425
Q

What are the primary goals in managing DKA and NKHS?

A

The primary goals are rehydration, electrolyte stabilization, blood glucose control, and resolution of acidosis (in DKA).

426
Q

How does dehydration contribute to hyperglycemia in DKA and NKHS?

A

Dehydration reduces renal clearance of glucose, exacerbating hyperglycemia in both conditions.

427
Q

What type of IV fluid is commonly used after initial saline in DKA?

A

After initial saline, dextrose with saline may be used to maintain blood glucose and continue ketosis correction.

428
Q

In what situation should lactated Ringer’s be avoided in DKA management?

A

Lactated Ringer’s is avoided if acidosis is severe, as it contains lactate, which can increase lactic acid levels.

429
Q

Why is frequent re-evaluation of electrolytes necessary in DKA/NKHS?

A

Insulin and fluids shift electrolytes, so frequent checks prevent imbalances, especially for potassium.

430
Q

What does a normal anion gap signify in a DKA patient?

A

A normal anion gap indicates resolution of ketoacidosis.

431
Q

How does DKA differ from NKHS in terms of ketone levels?

A

DKA has high ketone levels due to fatty acid breakdown, while NKHS typically has little to no ketones.

432
Q

What clinical signs indicate effective rehydration in NKHS?

A

Improved blood pressure, heart rate normalization, and increased urine output suggest effective rehydration.

433
Q

Why might metabolic acidosis persist even after initial treatment in DKA?

A

Acidosis can persist due to continued ketone production or delayed renal clearance of acids.

434
Q

What symptom suggests hypovolemic shock in DKA?

A

Severe hypotension, tachycardia, and poor perfusion suggest hypovolemic shock from dehydration.

435
Q

Why are regular capillary blood glucose checks essential during insulin infusion?

A

Frequent checks help adjust insulin and prevent hypoglycemia as blood glucose levels fluctuate.

436
Q

When should subcutaneous insulin be started after IV insulin in DKA?

A

Subcutaneous insulin can start when the patient is eating, and anion gap has normalized to transition off IV insulin.

437
Q

What are the signs of hyperglycemic hyperosmolar state (HHS) that distinguish it from DKA?

A

HHS typically lacks ketoacidosis but presents with extreme hyperglycemia, severe dehydration, and high serum osmolarity.

438
Q

What blood glucose level is often seen in HHS patients?

A

Blood glucose levels in HHS often exceed 600 mg/dL, much higher than in typical DKA cases.

439
Q

Why should patients with DKA or HHS be monitored for infection?

A

Infections are common precipitating factors for DKA and HHS, and they can worsen hyperglycemia and dehydration.

440
Q

How does dehydration in HHS affect blood viscosity?

A

Dehydration increases blood viscosity, raising the risk of thromboembolic events.

441
Q

What neurological symptoms might develop in HHS due to hyperosmolarity?

A

Symptoms can include confusion, seizures, and even coma as hyperosmolarity affects brain function.

442
Q

When might central venous pressure (CVP) monitoring be helpful in DKA/HHS management?

A

CVP monitoring may be used in severe cases to guide fluid resuscitation and prevent fluid overload.

443
Q

How is renal function typically impacted in patients with HHS?

A

Severe dehydration can lead to prerenal azotemia, characterized by elevated BUN and creatinine levels.

444
Q

What is the effect of glucagon release during DKA?

A

Glucagon promotes lipolysis and ketone production, worsening ketoacidosis.

445
Q

Why are fluids usually switched to half-normal saline in DKA after initial resuscitation?

A

Half-normal saline helps prevent hypernatremia and continues rehydration more gradually after initial volume replacement.

446
Q

What is the primary reason for polyuria in DKA?

A

High glucose levels lead to osmotic diuresis, resulting in significant fluid loss and dehydration.

447
Q

How does low insulin contribute to the development of DKA?

A

Low insulin levels lead to increased lipolysis and ketogenesis, causing ketoacidosis.

448
Q

Why is urine ketone testing less accurate than serum ketone testing in DKA?

A

Urine ketones lag behind serum changes and may not reflect real-time ketone levels.

449
Q

What can an elevated BUN/creatinine ratio indicate in DKA or HHS?

A

An elevated ratio suggests prerenal azotemia due to dehydration.

450
Q

How does metabolic acidosis manifest on an ABG in DKA?

A

Metabolic acidosis presents with a low pH and low bicarbonate on ABG testing.

451
Q

What can cause hypophosphatemia during DKA treatment?

A

Insulin shifts phosphate into cells, potentially leading to hypophosphatemia as rehydration and insulin therapy progress.

452
Q

Why is it important to avoid a rapid reduction in serum osmolarity in HHS?

A

A rapid decrease can cause osmotic shifts and cerebral edema, especially in elderly patients.

453
Q

What are the target glucose levels for transitioning from IV to subcutaneous insulin in DKA?

A

Target levels are around 200 mg/dL, along with a closed anion gap and the ability to tolerate oral intake.

454
Q

What role does sodium bicarbonate play in severe acidosis?

A

Sodium bicarbonate can buffer acidosis in life-threatening cases, though it’s typically avoided unless pH < 6.9.

455
Q

How do ketones contribute to the development of acidosis in DKA?

A

Ketones release hydrogen ions into the bloodstream, causing metabolic acidosis.

456
Q

What is the main clinical concern with persistent hyperglycemia in HHS?

A

Persistent hyperglycemia can cause severe dehydration and risk for thrombotic complications.

457
Q

How should fluids be adjusted as blood glucose levels decrease in DKA?

A
458
Q

How should fluids be adjusted as blood glucose levels decrease in DKA?

A

Once glucose drops below 250 mg/dL, fluids should be switched to include dextrose to prevent hypoglycemia.

459
Q

What is a safe rate of glucose reduction in HHS to prevent complications?

A

A gradual reduction of 50-75 mg/dL per hour is recommended to prevent rapid osmotic shifts.

460
Q

What are some signs of recovery in DKA patients?

A

Improved mental status, reduced anion gap, and stabilized electrolytes indicate recovery.

461
Q

What laboratory value is key to confirm the resolution of ketoacidosis in DKA?

A

The normalization of the anion gap is key to confirming ketoacidosis resolution.

462
Q

Why is regular mental status evaluation critical in HHS?

A

Changes in mental status may indicate worsening hyperosmolarity or potential complications like cerebral edema.

463
Q

How does polyphagia manifest in patients with DKA?

A

Polyphagia, or increased hunger, is due to cellular glucose starvation from lack of insulin.

464
Q

What electrolyte must be replaced cautiously due to risk of arrhythmias in DKA?

A

Potassium must be replaced carefully to prevent arrhythmias, especially as insulin is administered.

465
Q

When is phosphate replacement considered in DKA?

A

Phosphate replacement may be considered if levels are very low or if there are signs of weakness or respiratory failure.

466
Q

How often should electrolytes be monitored in DKA patients initially?

A

Electrolytes should be monitored every 2-4 hours initially to guide therapy adjustments.

467
Q

What can cause elevated lactate levels in DKA patients?

A

Elevated lactate may result from tissue hypoxia due to poor perfusion from severe dehydration.

468
Q

Why is hypomagnesemia a concern in DKA and HHS?

A

Hypomagnesemia can exacerbate arrhythmias and should be corrected if low.

469
Q

What role does insulin play in stopping ketone production in DKA?

A

Insulin inhibits lipolysis, reducing free fatty acid release and thus stopping ketone production.

470
Q

What initial fluid bolus is recommended for adult DKA patients with severe dehydration?

A

An initial bolus of 1-2 liters of normal saline is recommended to address severe dehydration.

471
Q

When can DKA patients be safely discharged?

A

Discharge is considered once patients are clinically stable, ketone-free, and can manage diabetes with subcutaneous insulin.

472
Q

Why is blood pH monitored in DKA?

A

Blood pH helps assess the severity of acidosis and response to treatment.

473
Q

What serum osmolality level indicates severe hyperosmolarity in HHS?

A

Serum osmolality >320 mOsm/kg indicates severe hyperosmolarity.

474
Q

How should fluids be modified in cases of pulmonary edema risk during DKA or HHS management?

A

Fluid administration should be slowed, and diuretics considered if pulmonary edema is a concern.

475
Q

Why might patients in DKA experience Kussmaul respirations?

A

Kussmaul respirations are a compensatory response to metabolic acidosis, helping expel CO2.

476
Q

How can hypoglycemia be prevented during the resolution phase of DKA treatment?

A

Adding dextrose to IV fluids when glucose falls below 250 mg/dL helps prevent hypoglycemia.

477
Q

Why is multidisciplinary care important in DKA and HHS management?

A

Multidisciplinary care ensures comprehensive management, including addressing underlying causes and complications.

478
Q

Why should arterial blood gases (ABG) be checked in severe DKA cases?

A

ABG can help assess the severity of acidosis and the need for aggressive intervention.

479
Q

What is the role of serum bicarbonate in evaluating the severity of DKA?

A

Low bicarbonate levels indicate a more severe metabolic acidosis, common in DKA.

480
Q

How does dehydration contribute to high blood glucose levels in HHS?

A

Dehydration reduces renal clearance of glucose, exacerbating hyperglycemia.

481
Q

Why is insulin administration delayed in some severe HHS cases?

A

Fluids are prioritized initially to correct dehydration; insulin is added after some fluid replacement.

482
Q

When should potassium be added to IV fluids during DKA treatment?

A

Potassium should be added once serum potassium falls below 5.3 mEq/L to prevent hypokalemia.

483
Q

What effect does hyperglycemia have on serum sodium levels in DKA?

A

Hyperglycemia causes pseudohyponatremia due to osmotic fluid shifts, lowering serum sodium.

484
Q

Why is serum osmolality important to monitor in HHS?

A

Serum osmolality helps gauge dehydration severity and risks of cerebral edema or neurological symptoms.

485
Q

How is pseudohyponatremia corrected in cases of severe hyperglycemia?

A

Sodium can be corrected by adding 1.6 mEq/L for every 100 mg/dL increase in glucose above normal.

486
Q

What might a positive urine ketone test in a DKA patient indicate?

A

It indicates ongoing ketogenesis and acidosis due to lack of insulin.

487
Q

How can excessive fluid resuscitation impact a DKA patient with renal impairment?

A

Overhydration can worsen renal function.

488
Q

What are common signs of peripheral sensory neuropathy?

A

Numbness, loss of temperature sensation, pain, and reduced pressure sensation.

489
Q

Which test is used to assess pressure sensation in patients with peripheral neuropathy?

A

The monofilament test.

490
Q

Why is it important to check foot pulsation in patients with peripheral neuropathy?

A

To assess for peripheral arterial disease, which can worsen neuropathy.

491
Q

What does Romberg’s test assess in the context of peripheral sensory neuropathy?

A

It evaluates sensory ataxia, helping determine if a patient can maintain balance when vision is removed.

492
Q

What role does proprioception play in the body?

A

Proprioception helps maintain balance and body awareness by sensing position and movement.

493
Q

What are the primary types of symptoms in diabetic neuropathy?

A

Sensory, motor, and autonomic symptoms.

494
Q

What is diabetic amyotrophy, and what are its symptoms?

A

A form of diabetic neuropathy causing pain, weakness, and muscle wasting.

495
Q

What are common autonomic symptoms in diabetic neuropathy?

A

Bladder and stomach issues, erectile dysfunction, and orthostatic hypotension.

496
Q

Why is glycemic control important in diabetic neuropathy?

A

It helps manage neuropathic pain and slow the progression of symptoms.

497
Q

What is Whipple’s triad, and what is its relevance to diabetes?

A

A diagnostic indicator of hypoglycemia, involving sweating, numbness, and palpitations that are relieved by glucose.

498
Q

At what blood glucose level do symptoms in Whipple’s triad typically occur?

A

Below 60 mg/dL.

499
Q

Why is it important to promptly recognize and treat hypoglycemia?

A

To prevent severe complications and potential loss of consciousness.

500
Q

What does the monofilament test evaluate?

A

It assesses pressure sensation in the feet to detect peripheral sensory neuropathy.

501
Q

How does peripheral arterial disease contribute to diabetic neuropathy?

A

It can worsen neuropathy by decreasing blood flow to the nerves, further impairing sensation.

502
Q

What does a positive Romberg’s test indicate?

A

Sensory ataxia, suggesting a loss of proprioception and balance issues.

503
Q

What are the sensory symptoms of diabetic neuropathy?

A

Numbness, tingling, burning sensations, and loss of sensation in the extremities.

504
Q

What is the role of motor neuropathy in diabetes?

A

It can cause muscle weakness, atrophy, and reduced coordination.

505
Q

How does autonomic neuropathy manifest in diabetes?

A

Symptoms such as gastroparesis, urinary incontinence, erectile dysfunction, and orthostatic hypotension.

506
Q

Why is it important to monitor urinary output in diabetic neuropathy patients?

A

It helps assess kidney function and detect early signs of diabetic nephropathy.

507
Q

What is the effect of poor glycemic control on diabetic neuropathy?

A

It accelerates the progression of neuropathy and worsens symptoms.

508
Q

How can autonomic neuropathy affect blood pressure regulation in diabetics?

A

It can lead to orthostatic hypotension due to impaired vascular response to changes in position.

509
Q

What is the primary treatment strategy for diabetic neuropathy?

A

Glycemic control, pain management, and symptom relief.

510
Q

What is the link between glycemic control and neuropathic pain in diabetes?

A

Good glycemic control helps reduce the intensity and progression of neuropathic pain.

511
Q

How can controlling blood glucose levels help prevent further nerve damage?

A

It prevents the accumulation of advanced glycation end products, which damage nerves.

512
Q

What is the role of medications in managing diabetic neuropathy?

A

Medications such as anticonvulsants, antidepressants, and pain relievers are used to manage neuropathic pain.

513
Q

What is the significance of regular foot exams in diabetic patients?

A

They help detect early signs of peripheral neuropathy and prevent complications like ulcers and infections.

514
Q

How does the loss of proprioception affect balance and coordination in diabetic neuropathy?

A

It leads to difficulty in maintaining body position and increases the risk of falls.

515
Q

What other conditions should be evaluated when diagnosing diabetic neuropathy?

A

Peripheral arterial disease and other vascular complications that can exacerbate neuropathy.

516
Q

What lifestyle modifications can help manage diabetic neuropathy?

A

Regular exercise, good glycemic control, and proper foot care.

517
Q

What tests are commonly used to diagnose diabetic neuropathy?

A

Monofilament testing, nerve conduction studies, and sensory testing.

518
Q

What is the risk of untreated diabetic neuropathy?

A

It can lead to ulcers, infections, amputations, and permanent nerve damage.

519
Q

How does the presence of diabetic neuropathy affect a patient’s quality of life?

A

It can impair mobility, cause chronic pain, and affect daily activities, reducing overall quality of life.

520
Q

How can patients with diabetic neuropathy protect their feet from injury?

A

Regularly checking their feet for injuries, wearing proper footwear, and avoiding walking barefoot.

521
Q

What role does smoking play in diabetic neuropathy?

A

Smoking exacerbates vascular problems and worsens neuropathy by reducing blood flow to nerves.

522
Q

Why is it important to manage blood pressure in patients with diabetic neuropathy?

A

High blood pressure can worsen neuropathy by damaging blood vessels and reducing circulation to the nerves.

523
Q

How can physical therapy help diabetic neuropathy patients?

A

It can improve strength, flexibility, and balance, helping to reduce falls and improve mobility.

524
Q

What is the importance of early detection of diabetic neuropathy?

A

Early detection allows for interventions that can slow progression and manage symptoms effectively.

525
Q

What dietary changes can help manage diabetic neuropathy?

A

A balanced diet to maintain stable blood glucose levels and prevent nutrient deficiencies that can worsen neuropathy.

526
Q

What role does vitamin supplementation play in managing diabetic neuropathy?

A

Certain vitamins, such as B12, can support nerve health and reduce symptoms of neuropathy.

527
Q

How can stress management techniques help with diabetic neuropathy?

A

Reducing stress can lower blood glucose levels and help with pain management and sleep disturbances.

528
Q

Why is foot care particularly important for diabetic neuropathy patients?

A

Diabetic neuropathy can cause loss of sensation in the feet, leading to unnoticed injuries and infections.

529
Q

What is the first step in the management of diabetic neuropathy?

A

Achieving good glycemic control to prevent further nerve damage.

530
Q

What complications can arise from untreated diabetic neuropathy?

A

Infections, ulcers, amputations, and significant impairments in mobility and sensation.

531
Q

How often should diabetic patients check their feet?

A

Daily, to detect any injuries, ulcers, or changes in the condition of the feet.

532
Q

How does sleep apnea affect diabetic neuropathy?

A

Sleep apnea can worsen glycemic control and increase the severity of neuropathic symptoms.

533
Q

Why should blood glucose not drop below 60 mg/dL in diabetic patients?

A

It can cause hypoglycemic symptoms, including dizziness, confusion, and seizures.

534
Q

What is the impact of uncontrolled blood sugar on the progression of diabetic neuropathy?

A

Uncontrolled blood sugar accelerates nerve damage and the development of symptoms.

535
Q

What is the significance of regular blood glucose monitoring for diabetic neuropathy patients?

A

It helps track glycemic control and prevent fluctuations that could exacerbate neuropathic symptoms.

536
Q

How do antioxidants benefit diabetic neuropathy patients?

A

Antioxidants may help reduce oxidative stress and protect nerve cells from further damage.

537
Q

How can managing cholesterol levels benefit diabetic neuropathy patients?

A

Lowering cholesterol can improve circulation, which helps reduce the impact of neuropathy.

538
Q

What is the role of nerve conduction studies in diagnosing diabetic neuropathy?

A

They assess the speed and strength of nerve signals to identify nerve damage or dysfunction.

539
Q

How can regular exercise benefit patients with diabetic neuropathy?

A

It improves circulation, reduces blood sugar levels, and can help alleviate neuropathic pain.

540
Q

What impact does uncontrolled blood sugar have on nerve endings?

A

It leads to the formation of advanced glycation end products that damage nerve endings.

541
Q

What type of diabetes is most associated with neuropathy complications?

A

Type 2 diabetes, due to the prolonged exposure to high blood glucose levels.

542
Q

What role do antioxidants play in preventing diabetic neuropathy?

A

Antioxidants can reduce oxidative stress, which contributes to nerve damage in diabetes.

543
Q

Why should diabetics with neuropathy avoid smoking?

A

Smoking reduces circulation and exacerbates vascular damage, worsening neuropathy.

544
Q

How does dyslipidemia relate to diabetic neuropathy?

A

High cholesterol and triglyceride levels can impair blood flow to nerves, increasing neuropathic symptoms.

545
Q

What is the relationship between high blood pressure and diabetic neuropathy?

A

High blood pressure worsens the vascular complications of diabetes, accelerating nerve damage.

546
Q

How often should blood pressure be monitored in diabetic patients with neuropathy?

A

Regularly, as hypertension can exacerbate neuropathy symptoms.

547
Q

What are the benefits of weight management for diabetic neuropathy patients?

A

Maintaining a healthy weight can help reduce the strain on nerves and improve blood glucose control.

548
Q

What is the first line of treatment for managing neuropathic pain in diabetes?

A

Tight glycemic control to prevent further nerve damage and the use of pain-relieving medications like antidepressants or anticonvulsants.

549
Q

How does glycemic variability affect nerve health in diabetics?

A

Frequent fluctuations in blood sugar levels can exacerbate nerve damage and worsen neuropathic symptoms.

550
Q

What is the role of the B12 vitamin in diabetic neuropathy?

A

Vitamin B12 helps maintain nerve health and its deficiency can worsen neuropathy symptoms.

551
Q

How can a diabetic diet help manage neuropathic symptoms?

A

A well-balanced diet with controlled carbohydrate intake helps maintain stable blood glucose levels, reducing nerve damage.

552
Q

What is the goal of pain management in diabetic neuropathy?

A

To improve quality of life by reducing pain, preventing further nerve damage, and managing other symptoms.

553
Q

What are the common treatments for neuropathic pain in diabetic patients?

A

Medications such as gabapentin, pregabalin, and duloxetine, alongside proper glycemic control.

554
Q

How can controlling triglyceride levels benefit diabetic neuropathy patients?

A

Reducing triglyceride levels can improve circulation, helping prevent nerve damage.

555
Q

Why is it important to manage stress in diabetic patients with neuropathy?

A

Stress can raise blood glucose levels and worsen the severity of neuropathic pain.

556
Q

How can massage therapy help with diabetic neuropathy?

A

It can improve circulation, reduce muscle tension, and alleviate pain.

557
Q

How does sleep apnea affect neuropathy in diabetics?

A

Sleep apnea can worsen glycemic control, increasing the risk of developing neuropathy.

558
Q

How often should patients with diabetic neuropathy be checked for foot ulcers?

A

Daily, as early detection can prevent complications like infections and amputations.

559
Q

What is the significance of glycemic variability in neuropathy progression?

A

Frequent high and low blood glucose fluctuations increase the risk of nerve damage and worsen symptoms.

560
Q

How does diabetes affect small and large nerve fibers?

A

Small fibers are typically affected early in diabetic neuropathy, leading to sensory changes, while large fibers contribute to motor and autonomic symptoms.

561
Q

What impact does uncontrolled diabetes have on the development of ulcers in patients with neuropathy?

A

Poor blood sugar control leads to poor wound healing and increases the risk of developing ulcers, particularly in the feet.

562
Q

What is the role of foot care education for diabetic patients with neuropathy?

A

It helps prevent injuries and complications like infections by educating patients on proper footwear, skin care, and daily foot checks.

563
Q

How does the loss of protective sensation affect the risk of injury in diabetic patients?

A

Loss of sensation increases the likelihood of unnoticed injuries, which can lead to infections and ulcers.

564
Q

How does the use of physical therapy help manage diabetic neuropathy?

A

It can improve strength, reduce pain, enhance balance, and prevent falls in patients with diabetic neuropathy.

565
Q

What is the role of blood glucose monitoring in diabetic neuropathy management?

A

It allows for tight control of blood sugar levels, preventing further nerve damage and worsening symptoms.

566
Q

How does foot deformity contribute to diabetic neuropathy complications?

A

Deformities, such as Charcot foot, can cause misalignment and increase the risk of pressure sores, leading to ulcers and infections.

567
Q

How can patients with diabetic neuropathy manage burning sensations in their feet?

A

Medications like pregabalin, gabapentin, or topical treatments can be used to alleviate burning sensations.

568
Q

How does vitamin D deficiency impact diabetic neuropathy?

A

Vitamin D deficiency can worsen neuropathic symptoms and overall nerve health.

569
Q

How does vitamin D deficiency impact diabetic neuropathy?

A

Vitamin D deficiency may exacerbate pain and worsen symptoms in diabetic neuropathy by impairing nerve function.

570
Q

Why should diabetics with neuropathy monitor for changes in vision?

A

Diabetes can lead to diabetic retinopathy, which can worsen neuropathy due to the compromised circulation.

571
Q

How does neuropathic pain from diabetes differ from other types of pain?

A

It is typically described as burning, tingling, stabbing, or shooting pain and may occur without a clear external cause.

572
Q

How does alcohol consumption affect diabetic neuropathy?

A

Chronic alcohol consumption can worsen neuropathy by increasing blood sugar levels and contributing to nerve damage.

573
Q

What are the risks associated with untreated diabetic neuropathy?

A

Increased risk of infections, amputations, ulcers, and significant functional impairments.

574
Q

What is the importance of a multidisciplinary approach in managing diabetic neuropathy?

A

Involvement of a team, including endocrinologists, podiatrists, and physical therapists, helps provide comprehensive care and improves outcomes.

575
Q

How can glycemic control reduce the risk of amputations in diabetic patients?

A

Tight blood sugar control prevents the progression of neuropathy and reduces the risk of complications that may lead to amputations.

576
Q

What should diabetics with neuropathy do if they notice changes in their skin color or temperature?

A

They should consult a healthcare provider to rule out infections, poor circulation, or other complications.

577
Q

How does chronic hyperglycemia lead to diabetic neuropathy?

A

It causes increased blood sugar levels, which lead to nerve damage due to the accumulation of harmful substances like sorbitol.

578
Q

What is the role of pain management in preventing the progression of diabetic neuropathy?

A

Effective pain management can improve quality of life and help patients remain active, which may prevent further complications.

579
Q

How can controlling blood lipids help in the management of diabetic neuropathy?

A

It can reduce the risk of vascular complications, which may contribute to worsening neuropathy.

580
Q

How does reducing blood pressure help prevent diabetic neuropathy progression?

A

It helps improve circulation, reducing the strain on nerves and slowing the progression of neuropathy.

581
Q

What is the benefit of physical therapy for improving balance in diabetic patients with neuropathy?

A

It can help patients regain stability and prevent falls by strengthening muscles and improving coordination.

582
Q

How does diabetes affect the autonomic nervous system?

A

It can lead to autonomic neuropathy, causing problems with heart rate, digestion, and other involuntary functions.

583
Q

What is the role of regular eye exams for diabetic neuropathy patients?

A

To detect diabetic retinopathy and other vision issues that may complicate neuropathy management.

584
Q

What is the significance of a high HbA1c level in diabetic neuropathy patients?

A

A high HbA1c indicates poor blood sugar control, increasing the risk of neuropathy progression.

585
Q

What are the long-term effects of uncontrolled diabetes on nerve health?

A

Prolonged high blood glucose levels can cause permanent nerve damage and increase the risk of amputations.

586
Q

Why should diabetic neuropathy patients avoid excessive heat on their feet?

A

Due to loss of sensation, they may not feel burns or injuries, which could lead to complications.

587
Q

What is the role of continuous glucose monitoring (CGM) in managing diabetic neuropathy?

A

CGM helps maintain stable blood glucose levels, reducing the risk of neuropathy progression.

588
Q

How can a diabetic patient reduce the risk of developing ulcers on their feet?

A

By wearing well-fitting shoes, avoiding walking barefoot, and performing daily foot checks.

589
Q

What is Charcot foot, and how does it relate to diabetes?

A

Charcot foot is a deformity caused by neuropathy, leading to joint destruction and misalignment in diabetic patients.

590
Q

How does diabetic nephropathy affect neuropathy progression?

A

Kidney damage from diabetes can worsen circulation, thereby increasing the risk of nerve damage.

591
Q

How can tight blood glucose control slow the progression of diabetic neuropathy?

A

It reduces the accumulation of harmful substances in the body, protecting nerve function.

592
Q

Why is it important for diabetic patients to monitor their foot temperature?

A

Changes in temperature may indicate poor circulation or infection, which require prompt attention.

593
Q

How do blood sugar spikes impact nerve function?

A

Sudden increases in blood glucose can lead to nerve inflammation, causing pain and discomfort.

594
Q

What is the relationship between blood glucose levels and nerve regeneration in diabetic neuropathy?

A

Maintaining optimal blood glucose levels promotes nerve repair and reduces further damage.

595
Q

What is the significance of glycemic control in preventing diabetic foot infections?

A

Stable blood glucose levels enhance immune function and help prevent infections.

596
Q

How do blood sugar fluctuations contribute to the development of neuropathy in diabetics?

A

Constant changes in blood sugar levels can damage nerves over time, increasing the risk of neuropathy.

597
Q

What is the connection between vitamin B12 deficiency and diabetic neuropathy?

A

Vitamin B12 is essential for nerve health, and its deficiency can exacerbate neuropathy symptoms.

598
Q

How does metabolic syndrome contribute to diabetic neuropathy?

A

Metabolic syndrome, which includes insulin resistance, increases the risk of nerve damage through poor glucose control.

599
Q

What is the role of glucosamine sulfate in diabetic neuropathy management?

A

It may help in alleviating joint pain and improving circulation, though more research is needed.

600
Q

What is the role of exercise in managing diabetic neuropathy?

A

Exercise improves blood circulation, reduces pain, and helps maintain healthy blood glucose levels.

601
Q

How does the use of statins help in managing diabetic neuropathy?

A

Statins lower cholesterol levels, improving circulation and reducing the risk of further nerve damage.

602
Q

What is the significance of daily foot inspections for diabetic patients with neuropathy?

A

Early detection of foot injuries or ulcers can prevent complications such as infections and amputations.

603
Q

How does autonomic neuropathy affect the digestive system in diabetics?

A

It can lead to gastroparesis, causing delayed stomach emptying, nausea, and bloating.

604
Q

Why are regular eye exams important for diabetic neuropathy patients?

A

Diabetes can cause diabetic retinopathy, which can worsen neuropathy due to poor circulation.

605
Q

How does alcohol consumption worsen neuropathy in diabetics?

A

Alcohol increases blood sugar variability and can lead to nerve damage when consumed in excess.

606
Q

What role does maintaining a healthy weight play in diabetic neuropathy prevention?

A

Healthy weight reduces the burden on nerves and improves blood circulation, helping prevent neuropathy.

607
Q

What is the role of a podiatrist in the care of diabetic patients with neuropathy?

A

Podiatrists help manage foot care, prevent ulcers, and treat deformities such as Charcot foot.

608
Q

How can diabetic neuropathy affect a patient’s ability to sense injuries?

A

Loss of sensation in the feet can lead to undetected wounds, increasing the risk of infection and complications.

609
Q

Why is it important to maintain normal blood pressure in diabetic patients with neuropathy?

A

High blood pressure can worsen the blood flow to nerves, accelerating nerve damage.

610
Q

What is the effect of glycemic variability on peripheral neuropathy?

A

Fluctuating glucose levels can increase oxidative stress, exacerbating neuropathy symptoms.

611
Q

How can diabetic patients reduce the risk of developing diabetic foot ulcers?

A

By wearing appropriate footwear, avoiding walking barefoot, and keeping feet clean and dry.

612
Q

What is the role of the A1C test in managing diabetic neuropathy?

A

The A1C test helps monitor long-term blood glucose control, which is crucial in preventing neuropathy.

613
Q

How does metabolic control impact the risk of developing diabetic neuropathy?

A

Poor metabolic control increases the risk of nerve damage, while good control can delay or prevent neuropathy.

614
Q

What is the role of gabapentin in managing diabetic neuropathy pain?

A

Gabapentin is commonly prescribed to help manage nerve-related pain by reducing nerve excitability.

615
Q

How does insulin resistance contribute to neuropathy in diabetes?

A

Insulin resistance leads to high blood glucose levels, which can damage nerves over time.

616
Q

How does neuropathy contribute to functional impairments in diabetics?

A

Neuropathy causes pain, muscle weakness, and balance problems, making daily activities difficult.

617
Q

How does diabetic neuropathy impact foot care in patients with poor circulation?

A

Poor circulation, combined with neuropathy, increases the risk of foot ulcers and infections.

618
Q

What is the role of pregabalin in treating diabetic neuropathy?

A

Pregabalin helps reduce pain and improve quality of life for patients with neuropathic pain.

619
Q

Why is it important for diabetic patients to maintain regular follow-ups with healthcare providers?

A

Regular checkups ensure that any complications, including neuropathy, are detected early and managed effectively.

620
Q

How does vitamin E deficiency affect diabetic neuropathy?

A

Vitamin E is an antioxidant that helps protect nerve tissue from damage caused by oxidative stress.

621
Q

How can pain management improve the quality of life for diabetic neuropathy patients?

A

Effective pain relief allows patients to maintain independence, engage in physical activities, and prevent depression.

622
Q

What are some non-pharmacological approaches to managing diabetic neuropathy pain?

A

Approaches include physical therapy, acupuncture, and transcutaneous electrical nerve stimulation (TENS).

623
Q

How can controlling triglyceride levels benefit neuropathy patients?

A

Lowering triglycerides can improve blood circulation, which helps slow down the progression of neuropathy.

624
Q

What is the impact of neuropathy on diabetic wound healing?

A

Neuropathy impairs the ability to feel injuries, leading to delayed healing and increased risk of infection.

625
Q

How does high blood sugar contribute to oxidative stress in diabetic neuropathy?

A

High blood sugar leads to the formation of free radicals, which damage nerve tissues and worsen neuropathy.

626
Q

Why is it crucial for diabetics to monitor their blood glucose levels frequently?

A

Regular monitoring helps maintain stable glucose levels, reducing the risk of complications like neuropathy.

627
Q

How does neuropathy influence balance and coordination in diabetics?

A

Sensory loss from neuropathy can lead to poor balance and coordination, increasing the risk of falls.

628
Q

What are the complications of untreated diabetic neuropathy?

A

Untreated neuropathy can lead to severe foot ulcers, amputations, chronic pain, and disability.

629
Q

How can a balanced diet aid in preventing neuropathy in diabetics?

A

A balanced diet helps control blood glucose levels and provides essential nutrients that support nerve health.

630
Q

What is the role of the monofilament test in assessing diabetic neuropathy?

A

The monofilament test checks for loss of sensation in the feet, helping identify early signs of neuropathy.

631
Q

What are the most common symptoms of diabetic autonomic neuropathy?

A

Symptoms include erectile dysfunction, bladder problems, gastrointestinal issues, and orthostatic hypotension.

632
Q

How does managing cholesterol levels impact diabetic neuropathy management?

A

Lower cholesterol improves blood flow, reducing the risk of nerve damage and worsening neuropathy.

633
Q

What is the significance of early diagnosis in preventing diabetic neuropathy progression?

A

Early detection allows for prompt treatment, which can prevent or delay nerve damage and related complications.

634
Q

How does low blood sugar (hypoglycemia) contribute to diabetic neuropathy?

A

Recurrent hypoglycemia can lead to nerve cell injury.

635
Q

What is the role of antioxidants in managing diabetic neuropathy?

A

Antioxidants help reduce oxidative stress, protecting nerve cells from damage caused by high blood glucose levels.

636
Q

How does tight glucose control help prevent diabetic neuropathy?

A

Tight glucose control reduces the amount of advanced glycation end products (AGEs), which can damage nerves.

637
Q

Why should diabetic patients avoid smoking to manage neuropathy?

A

Smoking constricts blood vessels, worsening circulation and exacerbating nerve damage.

638
Q

What is the effect of uncontrolled blood sugar on nerve fibers?

A

Chronic hyperglycemia damages nerve fibers, impairing their function and causing symptoms of neuropathy.

639
Q

How does the use of ACE inhibitors help prevent diabetic nephropathy and neuropathy?

A

ACE inhibitors improve kidney function and blood flow, which may also help reduce the risk of nerve damage.

640
Q

What is the connection between kidney disease and diabetic neuropathy?

A

Diabetic kidney disease can reduce circulation, worsening the progression of neuropathy.

641
Q

Why is it important to check for peripheral artery disease in diabetic patients with neuropathy?

A

Peripheral artery disease can worsen circulation and increase the risk of infections and amputations in patients with neuropathy.

642
Q

What is the importance of managing high cholesterol levels for diabetic neuropathy patients?

A

High cholesterol levels contribute to poor circulation, which can exacerbate nerve damage and delay healing.

643
Q

How does neuropathy affect the sensory system in diabetics?

A

Neuropathy damages the sensory nerves, leading to reduced ability to feel pain, temperature, and pressure.

644
Q

What is the relationship between sleep disturbances and diabetic neuropathy?

A

Chronic pain from neuropathy can lead to sleep problems, which in turn can worsen symptoms of neuropathy.

645
Q

How does managing blood pressure help reduce the risk of diabetic neuropathy?

A

Maintaining normal blood pressure improves blood flow to the nerves, which helps prevent or slow down nerve damage.

646
Q

What is the role of alpha-lipoic acid in diabetic neuropathy management?

A

Alpha-lipoic acid is an antioxidant that can help reduce symptoms of diabetic neuropathy, such as pain and tingling.

647
Q

Why is it essential for diabetic patients with neuropathy to monitor their blood pressure regularly?

A

Uncontrolled high blood pressure can damage nerves and worsen the symptoms of neuropathy.

648
Q

What is diabetic retinopathy, and how is it related to neuropathy?

A

Diabetic retinopathy is damage to the blood vessels in the eyes, often linked to poor blood glucose control, which also increases the risk of neuropathy.

649
Q

How does obesity contribute to the development of diabetic neuropathy?

A

Obesity worsens insulin resistance and inflammation, both of which contribute to nerve damage in diabetic patients.

650
Q

What is the significance of vitamin D in diabetic neuropathy management?

A

Vitamin D plays a role in nerve health, and deficiency can worsen neuropathic symptoms in diabetics.

651
Q

Why is regular physical activity important for managing diabetic neuropathy?

A

Physical activity helps improve blood flow, maintain weight, and manage blood sugar levels, reducing the progression of neuropathy.

652
Q

What role does the lipid profile play in managing diabetic neuropathy?

A

Abnormal lipid levels can contribute to vascular problems, worsening the progression of neuropathy in diabetic patients.

653
Q

How does poor glycemic control affect the kidneys in diabetic patients?

A

Poor glucose control leads to kidney damage, which can worsen neuropathy due to reduced circulation.

654
Q

What is the role of the monofilament test in detecting neuropathy?

A

The monofilament test assesses the loss of sensation in the feet, helping detect early-stage neuropathy.

655
Q

How does the consumption of omega-3 fatty acids help in diabetic neuropathy management?

A

Omega-3 fatty acids reduce inflammation and improve blood flow, potentially alleviating neuropathy symptoms.

656
Q

What is the relationship between diabetes and small fiber neuropathy?

A

Small fiber neuropathy, affecting the small nerve fibers responsible for pain and temperature sensations, is common in diabetics, especially with poor glucose control.

657
Q

Why is it important for diabetic patients to maintain a healthy diet to prevent neuropathy?

A

A balanced diet helps control blood glucose, cholesterol, and blood pressure, all of which are critical in preventing or managing neuropathy.

658
Q

How can increasing fiber intake benefit diabetic neuropathy patients?

A

A high-fiber diet helps control blood glucose and cholesterol, potentially improving circulation and reducing neuropathy symptoms.

659
Q

What is the role of sodium in the management of diabetic neuropathy?

A

Excess sodium intake can raise blood pressure and worsen neuropathy by affecting blood circulation.

660
Q

How does poor circulation contribute to the progression of diabetic neuropathy?

A

Poor circulation impairs nerve health by reducing oxygen and nutrient delivery to nerve tissues, accelerating damage.

661
Q

What is the significance of managing comorbidities in patients with diabetic neuropathy?

A

Managing comorbidities such as hypertension, hyperlipidemia, and kidney disease is essential in preventing further nerve damage.

662
Q

How can controlling inflammation help in managing diabetic neuropathy?

A

Inflammation accelerates nerve damage.

663
Q

How can controlling inflammation help in managing diabetic neuropathy?

A

Inflammation accelerates nerve damage in diabetic neuropathy, so controlling inflammation with diet or medication can help reduce symptoms.

664
Q

What is the role of SGLT2 inhibitors in managing diabetic neuropathy?

A

SGLT2 inhibitors improve glycemic control and may have protective effects on nerves by improving vascular health.

665
Q

How does the presence of infections complicate diabetic neuropathy?

A

Infections can exacerbate neuropathy symptoms, especially in the feet, by causing further damage and reducing circulation.

666
Q

What is the link between stress and diabetic neuropathy?

A

Chronic stress can increase blood sugar levels and inflammation, which may accelerate the progression of neuropathy.

667
Q

What role does physical therapy play in managing diabetic neuropathy?

A

Physical therapy helps improve strength, flexibility, and balance, which can help reduce the functional impact of neuropathy.

668
Q

How do diabetic patients with neuropathy benefit from wearing custom orthotics?

A

Custom orthotics provide support, reduce pressure, and help prevent foot injuries, which are common in neuropathic patients.

669
Q

Why is it important to manage alcohol consumption in diabetic neuropathy?

A

Alcohol can affect blood glucose levels, exacerbate nerve damage, and lead to poor nutritional intake, which worsens neuropathy.

670
Q

How can cognitive behavioral therapy (CBT) aid in managing neuropathic pain?

A

CBT helps patients cope with the emotional aspects of chronic pain and develop strategies to manage symptoms.

671
Q

What is the role of corticosteroids in treating diabetic neuropathy?

A

Corticosteroids may be used to reduce inflammation, but their use is limited due to potential side effects such as increased blood sugar levels.

672
Q

How does foot care education reduce the risk of complications in diabetic neuropathy patients?

A

Educating patients on proper foot care techniques can prevent injuries, infections, and complications like amputations.

673
Q

Why is neuropathy often underdiagnosed in diabetic patients?

A

Symptoms of neuropathy may be subtle at first, and patients may not recognize the importance of early intervention.

674
Q

How does diuretic use in diabetic patients impact neuropathy?

A

Diuretics can affect electrolyte balance and circulation, potentially worsening neuropathy symptoms.

675
Q

What is the role of antioxidant-rich foods in preventing diabetic neuropathy?

A

Antioxidants help neutralize free radicals, reducing oxidative damage to nerves and preventing neuropathy progression.

676
Q

Why is tight glycemic control particularly important during pregnancy for women with diabetes?

A

Tight control helps prevent complications like diabetic neuropathy, preeclampsia, and fetal issues associated with uncontrolled blood glucose.

677
Q

What are the risks of untreated diabetic neuropathy?

A

Untreated neuropathy can lead to severe complications, such as foot ulcers, infections, amputations, and chronic pain.

678
Q

How does diabetes-induced neuropathy impact the autonomic nervous system?

A

Autonomic neuropathy can cause problems with digestion, heart rate, and blood pressure regulation in diabetic patients.

679
Q

How does regular monitoring of blood glucose help in preventing diabetic neuropathy?

A

Regular monitoring allows for early adjustments to diet, medication, and lifestyle to maintain stable glucose levels and prevent nerve damage.

680
Q

What is the role of diet in managing blood pressure for diabetic neuropathy patients?

A

A healthy diet can help control blood pressure, which in turn improves circulation and reduces the risk of nerve damage.

681
Q

What is the potential benefit of using duloxetine in diabetic neuropathy management?

A

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that can reduce neuropathic pain and improve quality of life in diabetic neuropathy patients.

682
Q

How does vitamin B12 deficiency contribute to neuropathy in diabetic patients?

A

Vitamin B12 deficiency can worsen nerve function by impairing nerve regeneration and causing additional neurological damage, potentially exacerbating diabetic neuropathy.

683
Q

How does maintaining a healthy weight help prevent or manage diabetic neuropathy?

A

Maintaining a healthy weight helps improve insulin sensitivity, control blood glucose levels, and reduce strain on nerves, lowering the risk of neuropathy.

684
Q

Why are regular foot exams crucial for diabetic neuropathy patients?

A

Regular foot exams can help detect early signs of nerve damage or infection, preventing complications like ulcers or amputations.

685
Q

How do certain medications, like pregabalin, assist in managing diabetic neuropathy pain?

A

Pregabalin reduces the release of excitatory neurotransmitters, which helps decrease neuropathic pain by calming overactive nerve signals.

686
Q

What is the role of compression stockings in managing diabetic neuropathy?

A

Compression stockings improve circulation in the legs and feet, helping prevent the progression of neuropathy and reducing swelling.

687
Q

How can managing comorbid conditions, like hypothyroidism, help in treating diabetic neuropathy?

A

Proper management of hypothyroidism ensures better nerve function and reduces additional stress on the nervous system, which may help alleviate neuropathic symptoms.

688
Q

What is anovulation?

A

No corpus luteum production of progesterone

This leads to unopposed estrogen, hyperplastic endometrium, and irregular bleeding, increasing the risk of endometrial cancer.

689
Q

What is the effect of increased testosterone on LH levels?

A

Increased T LH levels lead to theca cell production of androgens

This process suppresses hepatic production of SHBG, resulting in elevated total testosterone and free testosterone.

690
Q

What is the consequence of unopposed estrogen due to anovulation?

A

Hyperplastic endometrium and irregular bleeding

This condition predisposes individuals to endometrial cancer.

691
Q

Fill in the blank: Anovulation results in _______ which can lead to endometrial cancer.

A

unopposed estrogen

692
Q

True or False: Increased testosterone levels suppress SHBG production.

A

True

693
Q

What does increased T LH levels indicate?

A

Theca cell production of androgens

This is a key part of the hormonal regulation in the ovaries.