נוירוטרנמיטרים - מפורט

Question 1

What are the 3 Glutamate receptors?

Answer 1

AMPA, NMDA, Kainate

Question 2

What is the main excitatory neurotranmitter?

Answer 2

Glutamate

Question 3

AMPA is?

Answer 3

Ionotropic receptor, Opens Na+, K+, EPSP, glutamate

Question 4

NMDA is?

Answer 4

glutamate metabotropic receptor that is involved with learning, EPSP, 4 binding sites, NT & voltage dependent (Glycine & depolarization)

Question 5

How does NMDA work?

Answer 5

High voltage (depolarization) causes release of mg from binding site, and a glycine molecule both enable this Glutamate receptor to let cations in, thus creating a EPSP

Question 6

Kainate is?

Answer 6

ionotropic glutamate recpetor, opens for Na+ and K+

Question 7

Glycine is?

Answer 7

NT, Inhibitory

Question 8

What is the receptor for Glycine? What does it open for?

Answer 8

GlyR, Opens for Cl-, IPSP, mainly CNS

Question 9

What is the main inhibitory NT?

Answer 9

GABA

Question 10

What are the 2 GABA receptors?

Answer 10

GABAa (ionotropic), GABAb (metatbotropic)

Question 11

GABAa is?

Answer 11

GABA ionotropic receptor with 5 binding sites, causes IPSP

Question 12

Link the behaviour of GABA to drugs

Answer 12

the GABAa receptor has 5 binding sites for, some are for tranqs, steroids and other shit.

Question 13

Agonists and antagonists of GABAa

Answer 13

Muscimol – direct agonist

Bicuculline – direct antagonist

Question 14

What is ACh?

Answer 14

Acetylcholine, an exitatory NT, mainly motoric but also learning

Question 15

What are the 2 ACh receptors?

Answer 15

Nicotinic – ionotropic – Na+ & K+ (and some Ca2+)

, Muscarinic – metabotropic – close K+

Question 16

AChE is?

Answer 16

Acetylcholinesterase, an enzyme that breaks ACh to acetate and choline for the sake of reuptake.

Question 17

What are the 2 Monoamine NT groups?

Answer 17

Catecholamine (dopamine, norepinephrine, epinephrine) and Indolamine (serotonin)

Question 18

what is the main type of Monoamine receptor?

Answer 18

Metabotropic for slow release

Question 19

what is the process of dopamine

Answer 19

tyrosine –> L-Dopa – > Dopamine

Question 20

dopamine receptors:

Answer 20

all meta, D1, D2… some IPSP some EPSP

Question 21

what is the norepinephrine process?

Answer 21

dopamine + Dopamine Beta-Hydroxylase enzyme

Question 22

norepinephrine receptors

Answer 22

metabotropic, usually EPSP (but some IPSP), alpha and beta

Question 23

what are the cathecolamine, Indolamine NTs?

Answer 23

CA - dopamin, norepinephrine

IA - Serotonin

Question 24

precursor of dopamine is

Answer 24

L-Dopa

Question 25

precursor of Glutamate is

Answer 25

MSG

Question 26

example of peptide NT

Answer 26

Opium