Zinc

Question 1

30-40 % of intracellular zinc is found where?

Answer 1

nucleus

Question 2

What are good sources of zinc?

Answer 2

red meats and seafood

Question 3

Major transporter used by zinc to cross brush border?

Answer 3

Zrt and Irt-like protein (ZIP4)

Question 4

Acrodermatitis enteropathica is caused by a mutation in what?

Answer 4

ZIP4

Question 5

Zinc inhibits absorption of what mineral?

Answer 5

copper

Question 6

What are the two families of zinc transporters?

Answer 6

1. ZnT family with 10 isoforms

2. ZIP family with 14

Question 7

How is zinc transported through the basolateral boarder membrane?

Answer 7

ZnT1

Question 8

Zinc can be used functionally in what?

Answer 8

metalloenzymes

Question 9

Zinc is transported into organelles and vesicles by what?

Answer 9

ZnT2 and ZnT7

Question 10

Zinc can be stored on what cysteine rich protein?

Answer 10

metallothionein

Question 11

Metallothionein binds how many zinc atoms?

Answer 11

7

Question 12

What are the most abundant isoforms of metallothionein?

Answer 12

MT1 and MT2

Question 13

ZIP14 transports what?

Answer 13

zinc into hepatocytes

- protective

Question 14

ZIP5 transports what?

Answer 14

zinc out of the body into intestinal cells and into the GI lumen for excretion

Question 15

In addition to zinc, metallothionein can also bind what?

Answer 15

copper, cadmium, and mercury

Question 16

What can be used as a zinc status marker?

Answer 16

Metallothionein

Question 17

What mineral is apart of more enzyme systems than all the other minerals combined?

Answer 17

zinc

Question 18

What are the 10 zinc dependent enzymes?

Answer 18

1. carbonic anhydrase
2. alcohol dehydrogenase
3. Carboxypeptidase
4. aminopeptidase
5. alkaline phosphatase (bone mineralization)
6. aminolevulinic acid dehydratase
7. superoxide dismutase (SOD)
8. Folylpolyglutamate carboxypeptidase
9. Collagenase and other matrix metalloproteinases
10. DNA/RNA polymerase

Question 19

The zinc dependent enzyme alkaline phosphatase is used for what?

Answer 19

bone mineralization

Question 20

In lead poisoning lead replaces zinc on what enzyme?

Answer 20

aminolevulinic acid dehydratase

- resulting in microcytic hypochromic anemia

Question 21

Zinc is a part of what taste protein?

Answer 21

gustin

Question 22

What important hormone needs zinc for structural stability?

Answer 22

insulin in the granules of pancreatic B-cells

- contains 2 zinc ions

Question 23

Polymorphisms of which zinc transporter may predispose them to type ll diabetes?

Answer 23

ZnT8

Question 24

How can zinc deficiencies affect immunity?

Answer 24

zinc deficiency can diminish thymulin activity which affects T cell numbers

Question 25

Zinc is needed for the hepatic synthesis of what?

Answer 25

retinol binding protein

Question 26

What does retinol binding protein do?

Answer 26

transports Vit A

Question 27

A zinc deficiency can result in what vitamin deficiency?

Answer 27

vitamin A

Question 28

Excess zinc stimulates synthesis of what?

Answer 28

thionein

Question 29

Thionein has a high affinity for what?

Answer 29

copper

Question 30

What directly inhibits zinc?

Answer 30

cadmium