zero to finals Flashcards
what can be used if there are contraindications to HRT
clonidine
what is an agonist of alpha 2 adrenergic receptors adn imidazoline receptors
clonidine
inidcations for HRT
premature ovarian insuffiency, vasomotor symptoms, low mood decreased. libido poor sleep joint pain, osteoporosis
best way to delvier oestrogen
patches
best way of providing progesterone
intrauterine device eg Mirena coil
should stop what 4 weeks before major surgery
oestrogen containing contraceptive or HRT
oestrogenic side effects
Nausea and bloating
Breast swelling
Breast tenderness
Headaches
Leg cramps
progestogenic side effects
Mood swings
Bloating
Fluid retention
Weight gain
Acne and greasy skin
what are the most common ovarian cyst
follicular cyst
when do folliculaar cysts tend to disappear
after a few menstrual cycles
corpus leteum cysts are often seen in
early pregnancy
dermoid cysts are particularly associated with
ovarian torsion
what increases the risk of ovarian cancer
the more ovulations
what is the tumour marker to remeber for ovarian cancer
ca- 125
cyst greater than – need referral to gynae
5cm
ovarian torsion may show
whirlpool sign, free fluid in pelvis and oedema of the ovary
the outer area of the cervix. visible on speculum exmantintion should eb
stratified squamous epithelium
vault prolapse is when
the top of the vagina descends into the vagina
antidepressant that can be given for stress incontinece
duloxetine
first line for urge inconcinence
bladder retraining
medication for urge incontince
anti cholinergics eg oxybutyin, tolterodine and solifenacin
alternative to anti cholinergics for urge incontince
Mirabegron
management for atrophic vaginitis
topical eostrogen
most common bacterial cause of barthoins abscess
e. coli
word catheter and marsupialisation are surgeries for
bartholins cyst
lichen sclerosis is thought to be what
autoimmune condition
mainstay of treatment for lichen sclerosus
topical steriods
upper vagina, cervixm uterus and fallopian tubes develop from the
paramesonephric ducts (mullerian ducts)
vaginal agenesis refers to an
absent vagina
in androgen insensitivity syndrome there are what instead of ovaries
testes
how does androgen insensitivity often present
infancy with inguinal hernia containing testes or at puberty with primary amenorrhoea
cervical cancer tends to peak in what age group
reproductive years
most common cause of cervical cancer
HPV
how does HPV promote the development of cnacer
it inhibits tumour supressor genes
how is CIN diagnosed
at colposcopy
smear sample looking for precancerous changes called
dyskaryosis
how often is smears in under 50
every 3 years
how often is smears in over 50
every 5
when do you get first smear
25
colposcopy if use acetic acid adn iodine solution
abnormal cells will turn white with the acid and with the iodine abnormal cells will not stain and healthy will stain a brown
usually management for CIN
LLETZ (large loop excision of the transformation zone) or cone biopsy
bavacizumab can be used for
metastatic or recurrent cervical cancer
current NHS vaccine for HPV is
Gardasil
HPV what causes cervical cancer
16 and 18
most endometrial cancers are what kind of cancers
ADENOCARCINOMAS!!!
KEY RF FOR ENDOMETRIAL CANCER ARE
OBESITY AND DIABETES
any woman presenting iwth postmenopausal bleeding has what until proven otherwise
endometrial cancer
endometrial hyperplasia may be trated with
progestogens eg Intrauterine Mirena or oral progestogen eg medroxyprogesterone or levonorgestrel
what appears to be protective against endometrial cancer in post menopasual woman by being anti oestrogenic
smoking
pipelle biopsy is highly sensitivie for
endometrial cancer
what may be used to slow the progression of endoemtrial cancer
progesterone
usual management for endometrial cancer
TAH and BSO - total abdominal hysterectomy with bilateral salpingo-oophorectomy
what cancer often presents late due to non specific symptoms and so has often already spread beyond the pelvis
ovarian
epithelial cell tumours are the most common ovarian cancer and out of these what is the most common
serous
krukenberg tumour refers to a metastasis in the ovary ususally from the
stomach
kruckenberg tumours have a characteristic
signet ring cells on histology
factors that reduce risk of ovarian caner
CCP, breastfeeding and pregnancy
ovarian mass may press on what nerve
obturator causing referred hip or groin pain
before referral for ovarian cancer what should you do
Ca125 blood test
most vulval cancer are
squamous cell carcinomas
around 5% of women with — get vulval cancer
lichen slerosus
vulvar cancers most frequently affects the
labia majora
is bacterial vaginosis sexually transmitted
no
what is the friendly bacteria in th vagina
lactobacilli
most common bacteria associated with bacterial vaginosis
gardnerella vaginalis
standard presenting feature of bacterial vaginosis is
fishy smelling dischage
bacterial vaginosis occurs with a pH greater than
4.5
clue cells on microscopy means
bacterial vaginossi
antibiotic of choice for treating bacterial vaginosis
Metronidazole
what to avoid if taking metronidazole
alcohol
thick white discharge that does not typically smell
candidiasis
warning if using antifungal cream or pessaries
they can damage latex condoms adn prevent spermicides working so alternative contraceptive is required for at least 5 days after use
what test are used to diagnose chlamydia
Nucleic acid amplification test (NAAT)
first line for chlaymdia is
doxycycline
what is doxycycline contraindicated in
pregancny and breastfeeding
what is a condition affecting the lymphoid tissue around the site of infectin with chlamydia
lymphogranuloma venerum
what infects mucous membranes with a columnar epithelium
gonorrhoea