Zebrafish Flashcards
1
Q
What is most replicative of myocardial infarction? Resection, Genetic ablation or cryoinjury?
A
Cryoinjury
2
Q
What are the three phases of cardiac repair in zebrafish?
A
1) Inflammatory phase
2) Reparative phase
3) Regenerative phase
3
Q
What are Neuropilins?
A
Co-receptors for several ligands (VEGF, PDGF etc)
The human genome encodes 2 neuropilins NRP1 and NRP2.
Zebrafish have 4; NRP1a, NRP1b and NRP2a, NRP2b
4
Q
What is the result of a neuropilin1a KO in zebrafish
A
A reduced regenerative capacity over time.
5
Q
What is optical projection tomography?
A
An optical version of CT scanning that can be used for fluorescent imaging. It does however require optically clear organisms such as zebrafish embryos or translucent mutant strains.
