Yuste C15: Emotions Flashcards

1
Q

What are emotions

A

physiological responses of the body to a particular stressor — either positive or negative

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2
Q

What are feelings

A

feelings are the conscious cognitive flavor that accompanies emotions.

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3
Q

Emotions vs feelings

A

emotions are unconscious, and are generated sub-cortically, whereas feelings are conscious, and involve the cortex. However, physiological responses are often the same for different emotions and different feelings. All mixed up.

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4
Q

Are the autonomic and enteric systems technically still part of the motor system?

A

yes, as they can generate motricity and behavior. But they are also fundamentally involved in internal states; an independent part of the nervous system; probably evolutionary remnants of an ancient nervous system; resemble the nervous system of cnidarians in their ganglionic structure and also in their heavy use of neuromodulators and peptides.

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5
Q

Why do we say the autonomic nervous system is motor?

A

neurons from the brain stem or the spinal cord (“preganglionic” neurons) activate autonomic neurons in ganglia that are located throughout the body, and these “postganglionic” neurons activate effector cells in the body, such as smooth muscle cells, cardiac muscle cells, or gland cells, for example; these postganglionic neurons resemble “motor” neurons, except that they are located outside the spinal cord and don’t control skeletal muscle, but other types of muscle.

The autonomic nervous system relays brain commands to activate non-skeletal muscle cells and glands through an intermediate set of neurons located in ganglia throughout the body.

it activates or inactivates a body response; it also generates reflexes

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6
Q

How is the autonomic system divided?

A

the sympathetic and the parasympathetic systems

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7
Q

Autonomic nervous system specialised for what

A

To generate and orchestrate “fight or flight” (or “fight or fright”) responses: those are critical, life-threatening moments in the life of an animal where it needs to either fight an adversary or escape a predator.
The sympathetic system does “fight” and the parasympathetic “flight”.

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8
Q

How do you make sure you are efficient in the fight or fright/flight responses

A

engage different parts of the body. For example, if you are fighting you need to increase heart rate and blood pressure, to better oxygenate the muscles, stop digestion and circulation to non essential organs, inhibit salivation, widen your pupils to gather more light, widen your bronchia to get more oxygen, stimulate your liver to deliver more glucose, erect your hairs in your skin and increase sweating to dissipate more heat, etc.

if you want to escape, or, if you want to escape and go unnoticed by a predator (”fright response”), or if you want to recover after a fight and relax, you need to do pretty much the opposite with respect to all these body organs, and also stimulate digestion, to generate energy to replenish the lost reserves.

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9
Q

Autonomic system general

A

Mostly antagonistic. With the sympathetic branch involved in arousal, defence, and escape behaviors, and the parasympathetic in eating and procreation.

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10
Q

Sympathetic ganglia

A

located in rows parallel to the spinal cord, and innervate essentially every organ in the body, or the blood vessels that irrigate them.

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11
Q

Parasympathetic ganglia

A

are right next to the organs that they innervate, and they avoid the skin and skeletal muscle.

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12
Q

Sympathetic vs parasympathetic innervation

A

each organ or part of the body receives dual sympathetic and parasympathetic innervation. Their opposite functions are due to the different neurotransmitters they release: sympathetic axons mostly release norepinephrine (noradrenaline), whereas parasympathetic axons mostly release acetylcholine. And these transmitters, acting through adrenergic or muscarinic receptors, together with peptides like vasointestinal peptide (VIP), have opposite physiological effects

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13
Q

The autonomic system also generates reflexes

A

the baroreceptor reflex, which critically controls our blood pressure, raising it or lowering it as our posture changes and controlling the redistribution of blood.

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14
Q

Autonomic system reflexes vs spinal cord reflexes

A

whereas the spinal cord innervates skeletal muscle, the autonomic innervates smooth and cardiac muscle.

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15
Q

Baroreceptor reflex

A

Needed because of impact of postural changes etc on blood pressure. When you sit down or lie down, and blood pressure increases above a certain level, the baroreceptors send action potentials to the nucleus of the solitary tract in the brain stem, which activates a series of circuits which engages the parasympathetic system and disengages the sympathetic system, causing dilation of blood vessels, decreased cardiac output, and decreased blood pressure. When you stand up, your blood pressure drops, the baroreceptors stop firing and stop activating the brainstem, removing the inhibition on the sympathetic system, and that speeds up the heart and contracts the arteries to increase your blood pressure.

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16
Q

Baroreceptors

A

located in the carotid sinus (in the cranial artery)
and in the aortic arteries to monitor blood pressure,
and have stretch receptors that are activated by high
blood pressure, or inactivated if the blood pressure
falls below a particular level

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17
Q

Baroreceptor reflex and control theory

A

a set point of ideal blood pressure, a sensor that measures blood pressure and a negative feedback loop (high blood pressure decreases it, whereas low blood pressure increases it), and a “gain” that controls how strong this feedback loop is.

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18
Q

Enteric nervous sustem covers what

A

The digestive system; essentially disconnected from the rest of the nervous system; also known as the “visceral” nervous system.

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19
Q

How is the enteric nervous system built

A

built as a system of two parallel nerve nets, or plexuses, in the intestinal wall, one next to the intestinal mucosa and another one next to the muscle layer; like in cnidarians, the neurons are spread out, without forming ganglia, and are loaded with peptides.

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20
Q

What do the neurons of the enteric nervous system do

A

They control secretion from the mucosa, vasodilation or vasoconstriction of the blood supply, and also activate or inhibit the smooth muscle in the intestinal wall. ==> generate reflexes.

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21
Q

CPG that generates peristalsis in the enteric nervous system

A

digestive tract as essentially a tube lined with smooth muscle with the goal of propelling food through. This is achieved by periodic waves of contraction behind the bolus of food with an associated relaxation ahead of it. A set of excitatory neurons activate muscle, while at the same time they activate inhibitory neurons located directly; underneath them (with GABA or glycine) to relax it. All you need is a circuit with asymmetry in the projections of the neurons from top to bottom and this anatomical asymmetry generates the functional asymmetry, which is expressed as a peristalsis.

Controlled by commands from above; triggered by stimulating particular nuclei in the brainstem.

22
Q

Hypothalamus location

A

a tiny nucleus at the base of the forebrain

23
Q

Hypothalamus composition

A

composed of many different subnuclei, all stuck together. 3 types of nuclei: anterior, posterior and descending nuclei. The hypothalamus also has a structure called the pituitary (or the hypophysis), which sits right next to the optic chiasm.

24
Q

Where do neurons from the hypothalamus synapse ==> implications

A

on neurons in the pituitary, which in turn secrete hormones, which are carried out by the blood stream to the rest of the body. That makes the hypothalamus-pituitary axis hormone central: it is the place from which the brain controls the hormonal state of the body.

25
Q

Importance of hormones

A

very likely that a lot of our behavior is controlled by hormonal signals through the blood stream (the “chemical” connectome).

26
Q

Anterior axis of the hypothalamus

A

hormone synthesis is a 2-step process: first, parvo cells (small cells) in the anterior hypothalamus synthesize a first set of hormones, called “releasing” hormones; activate receptor cells in the anterior pituitary. These pituitary neurons then release a second set of hormones, which are sent to the rest of the body through the blood stream.

27
Q

Why does the pituitary secrete hormones rather than the hypothalamus

A

Maybe for amplification purposes, or to enable more flexible regulation.

28
Q

Hormone pairs

A

TRH and TSH = sets the point of our bodies metabolism.
TRH and prolactin = controls production of milk in breast tissue
CRH and ACTH = release of cortisol from adrenal glands.
GHRH/GRH and GH = bone growth etc.
GnRH and LH + FSH = production of steroids in the gonads.
PIH inhibits prolactin release
GIH/GHRIH inhibits GH release

29
Q

Push-pull system of antagonistic levers

A

Like with prolactin and GH

30
Q

Posterior axis of the hypothalamus/pituitary

A

Neurons in the posterior hypothalamus (larger, magno cells) project to posterior pituitary and their axons branch around the blood vessels; these blood vessels form a mesh in order to collect all the hormones synthesized by the posterior hypothalamus and send them out to the rest of the body.

31
Q

Two main hormones secreted by posterior pituitary

A

Vasopressine (restricts production of urine and helps retain water if blood pressure drops or blood osmolarity increases); oxytocin (important for uterine contractions during birth and enhances lactation after birth; also social bonding).

32
Q

Vasopressin

A

NT or a hormone - bloodborne.

33
Q

Prairie moles and oxytocin

A

one of which is monogamous and other is not, and the difference seems to be determined by oxytocin.

34
Q

Descending hypothalamus

A

This is the part of the hypothalamus that talks to the brain stem and influences/triggers autonomic reflexes and CPGs.

35
Q

Emotion as a motor reflex

A

An emotional stimulus from the outside world is integrated by some emotional control center in the brain, which then triggers the autonomic system to react via the hypothalamus and brain stem and that engages the three branches of the nervous system (central, autonomic, and enteric), and generates a muscle, autonomic, and enteric physiological response.

36
Q

Emotions and CPGs

A

some emotional responses where there isn’t a clear emotional stimulus, or where the emotional stimulus modulates a basic emotional tone, can also be thought of as a CPG.

37
Q

The emotional integrator centre/command centre of the autonomic NS

A

in the Brainstem. Central Autonomic Network CAN; makes up a major part of the brainstem

38
Q

CAN

A

you connect the CNS with the autonomic and enteric nervous system. This happens via the connections that the CAN has with the rest of the brain, in particular the hypothalamus, the amygdala, and the “limbic lobe”.

39
Q

The limbic lobe

A

The limbic lobe is the part of the cortex involved in the control of many autonomic reflexes, encompasses the cingulate cortex and the insula cortex, entorhinal cortex, hippocampus, amygdala and parts of the temporal lobe.

40
Q

What happens if you section the forebrain of an animal and disconnect the cortex

A

This animal can not only survive (which goes to show you that we do not actually need the cortex to live) but they actually express rage. This demonstrates that we do not need the cortex for emotion.

41
Q

Hypothalamus and CAN

A

The hypothalamus can also be viewed an integrator for emotional stimuli. In fact, if the hypothalamus is removed (leaving the brainstem attached), then the animal does not have rage, so this demonstrates that the combination of CAN and hypothalamus is necessary/critical for emotions.

42
Q

Limbic cortex and learning

A

Seems important for some emotional learning. ==> fear conditioning in the cortical amygdala.

43
Q

Fear conditioning and mouse w/ neutral sound – why does this happen?

A

So any time the mouse hears the sound in the future, it will freeze, displaying a stereotyped classical behavior response to fear, mediated by the autonomic system. It turns out that both auditory (sound) and somatosensory (electric shock pain) stimuli go through the thalamus, up into their respective cortices, and they also go to the amygdala in parallel and converge in the lateral nucleus of the amygdala, which triggers an emotional response.

44
Q

LTP and fear conditioning

A

When the two stimuli happen at the same time, long-term synaptic plasticity (LTP) occurs in the lateral nucleus. And, once it happens, future auditory stimuli will automatically activate the amygdala circuits, even without the pain stimulus.

45
Q

Implication of fear conditioning regarding the amygdala

A

sensing important sensory inputs and giving them an emotional tone, according to the emotional salience of the stimulus. If you take out the amygdala, the animals still have normal emotions, but they cannot learn new fear emotions.

46
Q

Humans with amygdala lesions

A

Have a defect in fear conditioning. ==> the amygdala as functioning to generate emotional behaviors

47
Q

Emotional learning and the amygdala

A

both positive and negative emotions are learned by the amygdala; some amygdala nuclei are involved in innate fear.

48
Q

Limbic cortex and emotions ==> neural network

A

many different parts of the cortex light up in all kinds of emotions. We are dealing with a distributed system, a neural network again. In particular, there are three cortical areas that get preferentially activated: the cingulate, prefrontal, and somatosensory cortex.

49
Q

Cingulate cortex

A

Activated when you are sad or depressed. Depressed patients have big difference in activity here.

50
Q

Prefrontal cortex

A

Patients with prefrontal lesions usually have a dramatic change in their personality. They become disinhibited, lose empathy, are emotionally cold, and have no guilt.

51
Q

Primary somatosensory cortex

A

somatosensory cortex receives pain information may be part of this: there is a deep connection between somatosensation and positive and negative emotions.

52
Q

Importance of fear/ability to learn emotion

A

We use the memory of feelings to imagine future situations to steer our future behavior.