Yr4 Palliative Care - Lectures Flashcards
What is the definition of Palliative Care?
- List 8 Principles of Palliative Care.
Palliative care is an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial and spiritual.
What is the evidence for Palliative care?
List which symptoms cause the most distress at the end of life.
- Dyspnoea
- Pain
- Incontinence
- Nausea
- Psychological suffering
Describe the Traditional Model of Palliative Care in comparison to the Current model of care in regards to the timing of referrals.
Timing of referrals - Palliative care referrals are generally made when there is need for :
1. Pain management
2. Symptom management
3. Psychosocial support
4. Counseling
5. Terminal care (often far too late!)
What is the Palliative Care-Enhanced Model?
What is the model of palliative care in Australia?
List the palliative care services available in WA.
List 5 Patient Factors Causing Particular Challenges in Communication in Palliative Care.
- What are the qualities of the health professional that may help/hinder communication?
Patient Factors Causing Particular Challenges in Communication
1. Hearing impairment
2. Visual impairment
3. Cognitive impairment
4. Dysphasia/ Dysarthria
5. Language/Cultural differences
Outline a Framework for Palliative Care in Community-based aged care patients.
What is Palliative Care? Define it.
Palliative care is person and family-centred care provided for a person with an active, progressive, advanced disease, who has little or no prospect of cure and who is expected to die, and for whom the primary goal is to optimise the quality of life.
When is palliative care
appropriate?
- Why do we have palliative care? (4)
Palliative Care is:
- applicable early in the course of illness
- in conjunction with other therapies that are intended to prolong life, such as chemotherapy or radiation therapy,
- includes those investigations needed to better understand and manage distressing clinical complications.
True or False: most people suffer severe pain when they die.
- What factors influence patient outcomes? (3)
Reality in Australia
Palliative Care Outcomes Collaboration data show:
- statistically significant improvement in pain and other symptoms over the last decade
- 26% of all palliative care patients report 1 or more severe symptom when starting palliative care
- This decreases to 13.9% as death approaches.
List 6 Adverse Effects of Opioids prescribed for pain in palliative care and their treatments.
- Constipation –> Aperients
- Drowsiness –> Psychostimulants
- Nausea/vomiting –> Antiemetics
- Dry mouth –> Artificial saliva
- Delirium –> (Anti-psychotics :( )
- Myoclonic jerks –> Anticonvulsants
- Hallucinations
List the 6 Principles of Symptom Control in Palliative Care.
- Evaluation
- Explanation
- Set realistic goals
- Continuity of care
- Monitor and review
- Prophylactic prescribing
What individual factors may affect how you prescribe in pall care?
Individualise:
1. Preference
2. Ability
3. Age
4. Pharmacokinetics
5. Current and previous drug history,
6. Duration of treatment
What are 3 outcomes measures for drug therapy in
palliative care?
Outcome measures of drug therapy in
palliative care
1. Hard to define and measure
2. Not curing
3. Not reducing disease burden
Why might PO meds not be suitable for palliative care patients?
- 2 conditions?
The absorption and handling of oral
medications may be disrupted
1. “Ileus”
2. Constipation
3. Mechanical obstruction
4. Extrinsic compression by ascites)
If nausea or vomiting present - Avoid oral route.
Gut dysfunction - Also diabetes & parkinsons = delayed gastric emptying = impact oral absorption
TRUE or FALSE: The steady state drug concentration is dependent on the size of the body.
In which circumstances may you be concerned about drug elimination in palliative care?
- Which drugs should be avoided when there is deranged liver function?
Elimination: Liver
- Advanced hepatic tumor load rarely causes significant effect
- Except in abnormal shunting of blood
from portal to systemic circulation
- Deranged liver function = Reduced first pass metabolism - Eg Targin (naloxone systemic absorption)
- CYP interactions
- Beware hepatotoxic drugs
- Avoid paracetamol if transaminases are up 3 x limit normal
- Valproate - can be hepatotoxic - used for seizure control = eg. Pt with a glioblastoma or pain relief
What considerations need to be made regarding drug elimination for palliative care patients?
- What is morphine? How is it metabolised?
- How is morphine & its metabolites eliminated?
- What GFR is a predictor of adverse effects?
- Which opioids would you give in impaired renal excretion?
- Why may parenteral infusion of morphine minimise adverse side effects attributed to metabolites?
Morphine elimination
- mu-opioid receptor agonist
- principal effects in CNS and GIT
- metabolised in the liver to
1. Morphine-3-glucuronide
2. Morphine-6-glucuronide and others
- M6G is analgesic = 5 x potency of parent morphine & significantly contributes to analgesia in chronic dosing
What is the approximate absorption/half life of SR opioids?
- What options do we have for SR oral opioids? (6)
Sustained-release opioids
Most opioids have a rapid absorption and short half-life
- e.g. morphine: t½ = 2 to 4 hours
To maintain stable drug levels:
- Dose interval 4 hourly or less
- SR formulations alter the rate of dissolution
- the effective absorption is artificially slowed
What are the 3 options for Transdermal SR Opioids and how often are the patches changed?
- Role of Buprenorphine in Pall care?
Buphrenorphine different to other opioids because its a weak partial mu-opioid agonist and a weak kappa-opioid receptor antagonist.
- Considered safer
- Good for post-op patients
- Bad for pall care as the antagonist action can block other opioids that may be prescribed and there tends to be a ceiling effect so not good for pall pts with increasing pain
How does the time to peak and duration of IR compare to SR for Oral Opioids?
Pts require slow release & PR Immediate release for PRN/breakthrough
List 3 Advantages & 5 Disadvantages of SR Opioids?
SR Advantages
2. Convenience
2. Improved compliance
3. Less fluctuation in plasma levels
SR Disadvantages
1. Amount of drug bay be far higher than that contained in a single conventional (IR) dose
2. Damage to the SR mechanism poses risk - Consider if capsule of SR breaks you are dumping entire 24hr dose in one go = issues with tox
3. Once an SR drug releases it is difficult to stop
4. Impact of GI transit time on absorption
5. Opioid and anticholinergics may worsen delayed gastric emptying
What might duloxetine cause/exacerbate?
- Risk of dexamethasone?
- Naproxen?
- Give 2 examples of when side effects may be used beneficially?
A knowledge of ALL side effects is valuable
- The propensity for duloxetine to cause or exacerbate hyponatraemia could be a relative contra-indication!
- The risk of dexamethasone induced proximal myopathy might be a relative contraindication where mobility was already compromised.
- Naproxen may cause gastric intolerance
Discuss the role of Multi-modal analgesia vs. polypharmacy in palliative care?
Multi-modal analgesia vs. polypharmacy
Polypharmacy is common in the palliative care patient population because
- Patients are often elderly
- Multiple co-morbidities
- Multiple symptoms requiring palliation
The contemporary approach to effective analgesia encourages co administration of multiple drugs providing analgesia by differing mechanisms…
What are the different priorities in the management of chronic non-malignant vs. pain in patients receiving palliative care?
What are the 10 basic principles of analgesia in the palliative care patient?
10 Basic Principles of Analgesia in the Palliative Care Patient
- 1. Use the oral route when possible - Why?
- 2. Prescribe regular and prn analgesia for persistent pain?
- What dose of opioid would you give for rescue opioid?
- When would you increase the background opioid dose?
1. Use the oral route when possible
- Ease of administration
- Minimises risk
- Easily transferable to a home setting
- Rescue PRN dose for opioids = approx 1/10th of their daily background dose
- If PRN >3xday —> increased background opioid dose OR consider non-opioid responsive causes
3. Recognise and treat breakthrough pain
(BTP)
- What is BTP?
- Tx?
- Dose?
- Therapies for BTP?
Describe the ideal BTP management?
- BTP = breakthrough pain
Opioids for breakthrough pain relief - What is the dosing interval dependent on?
- What is the frequency of dosing for non-opioid analgesics dependent on?
- Why are IR opioids only used for PRNs?
Opioids for breakthrough pain relief
- IR opioid dosing interval in response to sub-therapeutic plasma levels is determined by Tmax (time to peak plasma level.)
- Breakthrough dosing intervals are dependant on the ROUTE of ADMINISTRATION rather than the particular opioid chosen.
- For non-opioid and adjuvant analgesics the dosing interval is related to the ½-life of the drug.
- When using opioids to relieve breakthrough pain, the intent is to rapidly raise the opioid plasma levels to exceed the present (temporary) analgesic threshold.
- Because a rapid response is desired use only immediate-release opioids on a prn basis.
- If you can be certain that plasma opioid levels have already peaked without the desired analgesic effect, it is reasonable to repeat the IR opioid dose.
Principles of Pain Management in Palliative Care - 4. Use the analgesic ladder as a guide?
Why do we Consider using multi-modal analgesia in pall care?
- Why do we need a variety of pharmacological agents to control pain? (give examples)
- Sub-maximal dosages of two, three or more drugs may result in improved analgesic efficacy and fewer adverse effects than maximal dosages of a single drug.
- Non-opioid analgesics should be continued when opioids are introduced IF THEY HAVE BEEN OF BENEFIT, and may be helpful even for patients on moderate doses of opioid
Multi-modal Analgesia
- Why must you understand the mechanism of pain before you can choose an appropriate analgesic?
- When would you reduce paracetamol dose?
- What is the role of NSAIDs in pall care analgesia?
Using multi-modal analgesia in practice
- Classify the type of pain: Nociceptive (Somatic/Visceral) vs. Neuropathic
- Understanding the different mechanisms of pain can help guide the choice of analgesic agent
- Make use of the wide range of oral or transdermal sustained-release opioids now available along with appropriate non-opioids
- When patients are entering the terminal phase use imagination and all available forms of administration (parenteral infusions, sublingual, transdermal, rectal) to continue using multi-modal therapy where possible if of proven benefit
How do we do conversion doses for methadone?
You don’t! Remember that if you are ever asked to convert to or substitute methadone for an opioid, insist on the need to seek advice from an expert and experienced Pain Specialist or Pall Care Specialist.
What can too little opioid analgesia cause in the palliative care patient? (2)
What can too much opioid analgesia cause? (6)
- Apply patch at same time of last dose of SR oxycontin as it will take up to 24hrs to ready steady state
- Need to check her renal function —> if she’s in renal failure she may be accuulating oxycontin which is causing her disorientation/drowsiness ALSO is this her usual dose
- Could use a subcut infusion of morphine - steps: 1. 40mg oxyctonin convert to 60mg of oral morphine (x1.5) then convert oral morphine to subcut morphine by diving by 3 = 20mg of subcut morphine over 24hrs
- Always covert to morphine and oral then to whatever you need
Analgesic equivalents
- A patient is prescribed morphine 10mg injection 4-hourly prn subcutaneously
- Patient became unresponsive
- Respiratory rate 8/minute
- Pupils pin-point
- Use the opioid conversion guide to calculate equi-analgesic alternatives to oral oxycodone 40mg/24 hours.
Ongoing management
An appropriate regimen might include:
1. IV paracetamol
2. Rectal indomethacin
3. Equivalent analgesic dose of an opioid
4. Confidence that depressed level of consciousness is due to the disease process, rather than overdose of opioid
Principles of Pain Management in Palliative Care
- Why do we Avoid mixing different opioid analgesics where possible? (6)
- How can we be proactive in managing side-effects?
- No proven benefit
- Causes confusion
- Increases risk of errors
- More difficult to calculate appropriate background and prn doses
- Sometimes necessary due to lack of availability of suitable preparations e.g. fentanyl, methadone
- In some situations, changing to another opioid (opioid rotation) can be helpful
Principles of Pain Management in Palliative Care
- What are some red flags from the history that may mean we have missed something in regards to a patient’s pain?
- What is the 10th principle of pain management in pall care?
- Rapidly escalating opioid requirements usually mean we have missed something!
- Morphine requirements exceeding 250mg orally per day (or equivalent for other opioids) should prompt a review
- Be alert to dose-limiting side effects.
List 9 Potential Goals of Care in Medicine?
- How might a person’s goals of care
impact on decision-making?
Historically, a dichotomous division of goals of care
- Focus on curing illness Little attention to relief of suffering, care of dying
- Hospice / palliative care arose in response to a need.
Can multiple goals of care exist in medicine?
How might goals of care change? What potential precipitating factors can you think of for this?
Describe the Contemporary model of intent of treatment.
Multiple goals of care
- Multiple goals often apply simultaneously
- Goals are often contradictory
- Certain goals may take priority over others
- You need to understand what the patient’s priorities and preferences are every step of the way
Goals may change
- Some take precedence over others
- The shift in focus of care: may be gradual, may be rapid, is an expected part of the continuum of medical care.
- Review with any change in:
1. Health status
2. Advancing illness
3. Setting of care
4. Treatment preferences
Outline a 7 step protocol to
negotiate goals of care.
- What happens when the physician cannot support a patient’s choices? Examples?
- Create the right setting
- Determine what the patient and family know
- Explore what they are expecting/ hoping for
- Suggest realistic goals
- Respond empathically
- Make a plan and follow-through
- Review and revise periodically, as appropriate
What 5 things must a person have/do in order to have capacity?
- Who can determine capacity?
- What does it vary by?
- Does a person with dementia have capacity?
“Capacity” implies the ability to understand and make own decision.
Patient must:
1. Retain and understand the information
2. Use the information rationally
3. Appreciate the consequences
4. Come to a reasonable decision for him or herself
5. Communicate the decision
Any doctor can determine capacity
* Capacity varies by decision
* Other cognitive abilities do not need to be intact