YOPS Flashcards
a cell penetrating scaffold protein
interferes with immune cell signalling, particularly targeting Natural Killer (NK) cells
suppresses the host’s immune response
YopM
a GTPase activating protein
plays a major role in the initial bacterial defense against phagocytes
disrupts actin cytoskeleton of host cells, inhibiting phagocytosis
YopE
an irreversible inhibitor of Rho-GTPases
a cystine protease that cleaves Rho-GTPases, leading to the disruption of the host cell’s cytoskeleton
YopT
a multi domain effector protein
aka Yersinia protein kinase A (YpkA)
a serine/threonine kinase and GTPase-activating protein that disrupts the actin cytoskeleton and inhibits phagocytosis
compromises membrane localization, serine/threonine kinase, and GDI domain
YopO
a highly potent anti-inflammatory effector protein
an acetyl transferase that blocks signalling pathways
causes the disruption of pro-inflammatory cytokine production and macrophage apoptosis
YopP
a versatile phosphotyrosine
dephosphorylates focal adhesion points, disrupting signal transduction in host cells
inhibits phagocytosis and the immune response by preventing the activation of immune signalling pathways
YopH
YOPS
Yersinia outer-membrane proteins
a set of virulence factors used by Yesinia spp. to evade the immune system and establish infection by:
inhibiting phagocytosis of neutrophils and macrophages
inhibiting cytokine production of macrophages
Yersinia outer-membrane proteins (YOPS)
