XVII - The Pancreas Flashcards
This disease is characterized by the following morphological changes: (1) microvascular leakage causing edema, (2) necrosis of fat by lipases, (3) an acute inflammatory reaction, (4) proteolytic destruction of parenchyma, (5) destruction of blood vessels with hemorrhage
Acute pancreatitis (TOPNOTCH) Robbins Basic Pathology, 8th ed., pg. 677
Extensive pancreatic parenchymal necrosis accompanied by diffuse hemorrhage.
Hemorrhagic pancreatitis(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 678
Cardinal manifestation of acute pancreatitis.
Abdominal pain(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 679
Necrosis of pancreatic tissue affecting acinar and ductal tissues as well as the islets of Langerhans; vascular damage causes hemorrhage into the parenchyma.Macroscopically, the pancreas exhibits red-black hemorrhage interspersed with foci of yellow-white, chalky fat necrosis.
Acute necrotizing pancreatitis(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 678
Solitary, 2-30 cm lesions of the pancreas, formed by walling-off of areas with hemorrhagic fat necrosis.Composed of necrotic debris encased by fibrous walls of granulation tissue, and lacks epithelial lining.
Pancreatic pseudocysts(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 679
Characterized by parenchymal fibrosis, reduced number and size of acini, and variable dilation of the pancreatic ducts. With relative sparing of Islets of Langerhans. Ductal concretions are present.
Chronic pancreatitis(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 680
Presents as painless, slow-growing cystic masses filled with thick, tenacious mucin, lined with columnar mucinous epithelium, associated with densely cellular stroma. Almost always arise in women.
Mucinous cystic neoplasm of the pancreas(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 681
Similar to mucinous cystic neoplasms but appear more frequently in men.
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 682
Most common location of pancreatic cancer.
Head of pancreas(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 684
Most common symptom of pancreatic carcinoma located at the tail and body of the gland?
None/AsymptomaticSince it does not impinge on the biliary tract, it may be quite large and widely disseminated by the time they are discovered.(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 684
Moderately to poorly differentiated adenocarcinoma forming abortive tubular structures or cell clusters and exhibiting an aggressive, deeply infiltrative growth pattern.
Pancreatic carcinoma(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 684
Type of pancreatic carcinoma showing prominent acinar cell differentiation with zymogen granules and exocrine enzyme production.
Acinar cell carcinomas(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 684
Type of pancreatic carcinoma with focal squamous differentiation in addition to glandular differentiation.
Adenosquamous carcinomas(TOPNOTCH)Robbins Basic Pathology, 8th ed., pg. 684
What is the most common clinically significant congenital anomaly of the pancreas?
Pancreas Divisum(TOPNOTCH)
This congenital abnormality develops embryologically when one portion of the ventral pancreatic primordium becomes fixed, while the other portion of this primordium is drawn around the duodenum
Annular Pancreas(TOPNOTCH)