X LINKED GENES/DOSAGE COMP Flashcards
1
Q
Who is mostly affected by an X linked disease?
A
Males
2
Q
What are the two forms of X inactivation?
A
Random and imprinted
3
Q
What is the structure called where female mammals silence one of their X chromosomes?
A
Barr body
4
Q
What initiates and controls the x inactivation process?
A
complementary RNAS
5
Q
What are the complementary RNAs involved in X inactivation?
A
XIST and TSIX
6
Q
What is imprinted X inactivation?
A
When the fathers X chromosome is silenced in the placenta
7
Q
What is random X inactivation?
A
The maternal or paternal X chromosome can become inactivated whilst in the embryo
8
Q
What is dosage compensation in mammals?
A
Balances the levels of X linked gene products between sexes
