Wurpel epilepsy Flashcards
What are the AED VOC-Na+ channel blockers
(Fos)Phenytoin (CYP 2C9, 2C19), Oxcarbamazepine (CYP 3A4, 1A2, 2C8), oxcarbazepine (Cytosolic enzymes & glucuronidation), esilcarbazepine (Glucuronidation), zpnisamide (CYP 3A4, 2C19), cenobamate (CYP B6,3A, C19)
Vigabatrin MOA and metabolism
inhibits GABA-T.
little/no metabolism
Valproate MOA and metabolism
inhibits GABA-T; blocks VOC-Na+; downregulate NMDA receptors.
CYP 2C9 2C19, glucuronidation.
Tigabine MOA and metabolism
inhibits GAT-1.
CYP 3A4
Retigabine MOA
neuronal KCNQ/Kv7
potassium channel opener
Lamotrigine MOA
blocks VOC-Na+ reducing GLU release
Ethosuzimide MOA and metabolism
blocks T-type Ca++ channels.
CYP 3A4, 2E1
Phenobarbital metabolism
CYP 2C19
What are the benzodiapzapenes
Diazepam, lorazepam, clonazepam
Gabepentin and pregabalin MOA
alpha, delta subunits of VOC-Ca++
Locosamide MOA and info
- enhances slow inactivation of VOC-Na+ without affecting the fast inactivation of VOC-Na+.
- modulates collapsin response mediator protein 2 (CRMP-2) prevents formation of abnormal
neuronal connections in the brain. - only affects neurons which are depolarized or active for long periods of time, typical of neurons at
the focus of epilepsy. - CYP 2C19
Topiramate MOA
locks VOC-Na+; downregulate AMPA/Kainate receptors
Felbamate MOA and metabolism
blocks VOC-Na+; upregulate GABA receptors; downregulate NMDA receptors.
CYP 3A4, 2E1
Levetiracetam MOA and SE/ADR
reduce/inhibit transmitter release by binding to SV2A (storage vesicle
glycoprotein) inhibiting presynaptic Ca++ channel
SE - hydrolysis in plasma
Brivaracetam MOA and metabolism
SV2A ligand; inhibit Na+ channels
Amidase and 2C19
