WS: Epigenetics Flashcards
1
Q
Epigenetic change associated with Queen Bee phenotype (Caste change in bees)
A
- HDAC found to be inhibited
- Leads to more histone acetylation and euchromatin formation
- Results in translation of genes for Queen Bee phenotype
2
Q
What type of mutations (x2) regarding epigenetic machinery are commonly mutated in cancer?
A
- Overexpression of CENP-A found in several types of cancer -> extensive mislocalisation of epigenetic machinery
- POT1 mutation oppose telomerase inhibition and have been observed in familial melanoma cases among other cancer types
