Wright-Anemia Treatments

Question 1

What does this indicate?
Bone marrow aspirate with flow cytometry and cytogenetics
46, XX, del (5)(q13) aka 5q-

Answer 1

myelodysplastic syndrome

Question 2

What is the treatment for myelodysplastic syndrome?

Answer 2

Treatment
EPO (Procrit)
Will eventually be ineffective
Transfusions (supportive care)
Lenalinomide for 5q- 
Bone marrow modulating agent

Question 3

How do you treat Vit B12 deficiency?

Answer 3

Oral-1000-2000 mg po daily
IM-1000mg weekly x 8 weeks then monthly
Long term if pernicious anemia

Question 4

How do you treat folate deficiency?

Answer 4

Oral- 1 to 5 mg po daily

Treat until anemia resolved (usually 2 months)

Question 5

With these conditions: thalassemia, ACD, aplastic anemia…what would be the RDW?

Answer 5

WNL

Question 6

What would the iron studies look like for anemia of chronic disease?

Answer 6

serum iron low-normal; transferrin or TIBC low

Question 7

What is your first consult for anemia of an unknown source?

Answer 7

GI consult

Question 8

Which is a better treatment for iron deficiency anemia?

Trial of oral iron for 4-6 weeks
Ferrous sulfate 325mg po tid x 6 months

Answer 8

Ferrous sulfate 6 mo b/c it takes a while to fully restore the stores of iron

Question 9

Which is an appropriate treatment for anemia of chronic disease:
Iron
EPO?

Answer 9

EPO