Wounds and Wound Management Flashcards

1
Q

Skin consists of two main layers –

A

the epidermis and the dermis.

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2
Q

Describe the epidermis

A

Avascular keratinized stratified squamous epithelium

The stratum corneum is the outer layer of the epidermis.

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3
Q

Describe the dermis.

A

Underneath the epidermis

  • Thicker, vascular (blood and lymph vessels)
  • Tough fibroelastic tissue
  • Supportive and nourishing function
  • Rests on a layer of loose connective tissue - subcutis (hypodermis)

Subdermal plexus is of major importance.

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4
Q

Subcutis is composed of

A

adipose tissue, the cutaneous trunci muscle
and direct cutaneous arteries and veins.

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5
Q

Superficial blood supply in animals is different from

A

humans (musculocutaneous vessels) → thus we have different reconstructive techniques for each.

Musculocutaneous arteries in animals:
* Perpendicular to the skin surface
* Supply small portions of the skin

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6
Q

Direct cutaneous arteries in dogs and cats, vascularize…

A

most of the skin.

  • Parallel to the skin in the hypodermis
  • Arise from perforator arteries

Subdermal plexus is of major importance.

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7
Q

If you had an inner thigh wound what vessel would you use for your flap?

A

epigastric vessel number 9

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8
Q

Classification of wounds broadly:

A

open wounds and closed wounds.

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9
Q

Open wounds can be: (8)

A
  • Surgical incision
  • Laceration
  • Abrasion
  • Avulsion
  • Degloving
  • Shearing
  • Puncture
  • Bite/sting: cat/dog; snake; insect; tick
  • Firearm
  • Burn: thermal; chemical; electrical; radiation
  • Pressure sores
  • Cast- and bandage-related
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10
Q

Closed wounds can be: (4)

A
  • Contusion
  • Hematoma
  • Crush injury
  • Hygroma
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11
Q

Open would type: Avulsion, can be due to: (2)

A
  • Degloving
  • Shearing
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12
Q

Open would type: puncture, can also be due to: (2)

A
  • Bite/sting: cat/dog; snake; insect; tick
  • Firearm
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13
Q

Describe Incisional injuries and lacerations

A
  • Surgical or traumatic
  • Edges generally clean and free from tissue damage

Tend not to get infected
- Minimal contamination
- Sufficient bleeding to decrease tissue colonization
- Rarely significant damage to surrounding tissues

  • Deep wound requires physical exploration/imaging!
  • Surgical management
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14
Q

Describe Abrasions

A
  • Superficial damage not extending beyond the dermis
  • Frictional forces when moving parallel to a rough surface, usually at speed
  • Typically combination of graze, abrasion and avulsion
  • Generally heavily contaminated
  • Severe abrasions with ongoing tissue
    necrosis might become avulsions
  • Surgical vs open wound management (more commonly)
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15
Q

Describe avulsions: degloving injuries

A

Avulsion is the separation of tissue from their deeper attachments (usually including muscle).

Degloving refers to skin and deeper tissues torn from an extremity, just as a glove is removed from a hand (mechanical vs physiological).

  • Defects are often extensive and complex
  • May be initially free of bacterial contamination, but without appropriate wound management rapid colonization and infection of necrotic tissue will occur.
  • Degloved skin should be preserved where possible
  • Surgical/open wound management/in combination
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16
Q

Describe avulsions: shearing injuries

A
  • Usually involve loss of deeper tissues (including skin, tendons, muscle, possibly bone)
  • The joints of the distal limb frequently exposed
  • Heavily contaminated with bacteria and debris
  • Extremely prone to infection
  • Need for orthopedic surgery?
  • Open wound management
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17
Q

What is meant by “physiological degloving” (versus mechanical)?

A

physiological degloving refers to skin sloughing off due to necrosis caused by a defect in e.g. vascularization.

mechanical degloving by an object such as a car at high speed.

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18
Q

Describe puncture wounds.

A
  • Caused by any sharp object that pierces the skin to create a relatively small deficit or hole
  • Bite wounds (also insects/snakes); impalement (full penetration); oropharyngeal; firearm wounds (lead!?)
  • Contamination/infection variable
  • Damage assessment!
  • Risk of abscessation
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19
Q

Describe burn wounds.

A
  • Caused by extreme temperature (hot or cold) or by contact with a corrosive chemical substance, electricity or radiation.
  • 1st, 2nd, 3rd degree → thickness (damage)
  • ‘’Rule of nines“? (not accurate in veterinary medicine)
  • May require prolonged treatment, monitoring (inpatient)
  • Treatment depends on the case
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20
Q

Describe pressure sores.

A
  • Caused by pressure typically on the elbows and hocks of large dogs. Intact calluses don’t need treatment.
  • Open or closed wounds (e.g. hygroma is a closed pressure wound)
  • Hygromas are best treated medically (meaning not surgically), so bandaging, draining etc.
  • Open sores prone to infection (bones and joints)
  • Medical/surgical treatment for pressure sores.
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21
Q

Describe Cast- and bandage-related wounds

A

Iatrogenic wounds are common
* Ischemic injury due to overtight application of bandage
* Inadequate padding of vulnerable areas
* Excessive exercise, allowing bandage slippage
* Wet or dirty bandages (higher risk of bacterial strikethrough and infection)

Serious wounds may result in the loss of digits or limbs

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22
Q

Wound healing has four distinctive phases:

A
  • Acute inflammatory phase
  • Debridement phase (breakdown)
  • Proliferation phase (reparation)
  • Maturation phase (remodeling)

Several phases can occur at the same time.

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23
Q

Depending on the type of wound and its classification, one or several phases of wound healing can be (3) (characterize the healing)

A

accelerated, delayed or complicated.

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24
Q

The inflammatory phase of wound healing can be characterized by: (5)

A

redness / rubor
pain / dolor
heat / calor
swelling / tumor
loss of function / functio laesa

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25
Q

Describe the inflammatory phase of healing:

A

Lasts approximately 5 days

What occurs after wound occurrence:
1. Filling with blood and lymph (from damaged vessels)

  1. Immediate vasoconstriction of the damaged vessels (lasts 5-10 min)
  2. Vasodilation (dilutes toxic substances, provides nutrients and results in a blood clot)
  3. Epithelial cells begin to migrate from the wound periphery onto the exposed tissue
  4. The blood clot dries to form a scab
  5. White blood cells leaking into wounds initiate the debridement phase
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26
Q

Describe the debridement (breakdown) phase of healing:

A
  • Approximately 6-12 hours after injury (not always visible clinically)
  • Formed inflammatory exudate provides all the necessary phagocytic cells and proteolytic enzymes to deal with the demarcation
  • An exudate (of WBC, dead tissue, wound fluid) forms on the wound
  • Necrotic tissue impedes wound healing
  • Phase ends with the rejection of nonvital tissue
  • Debridement/break down phase sometimes combines with inflammatory phase
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27
Q

Debridement phase also known as?
Proliferation phase also known as?
Maturation phase also known as?

A
  • Debridement phase (breakdown)
  • Proliferation phase (reparation)
  • Maturation phase (remodelling)
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28
Q

Describe the Proliferation (reparation) phase of healing:

A

Is the repair phase

  • Approximately 3-5 days after injury
  • Signs of inflammation subside
  • Neovascularization

This phase is divided into 3 processes:
* Granulation
* Wound contraction
* Epithelialization

29
Q

Describe the Maturation (remodeling) phase of healing:

A
  • Increasing strength of the scar as a result of remodelling of tissue.
  • The newly formed collagen is arranged parallel to the tension lines of the skin.
  • Total duration can range from weeks to a year or even longer.
  • No or insufficient hair follicles, sweat and sebaceous glands, poor movability and elasticity and an absence of pigment.
  • The healed wound will never regain skin’s original strength.
30
Q

This proliferation/repair phase is divided into 3 processes:

A
  • Granulation
  • Wound contraction
  • Epithelialization
31
Q

Describe Proliferation phase granulation

A
  • Red irregular surface
  • Fragile tissue
  • Functions as a barrier to infection and a scaffold for migrating epithelial cells
  • Capillary network occurs through sprout formation of capillary endothelial cells on the wound surface
  • Granulation tissue formed at each wound edge at a rate of 0.4 to 1 mm/24h
32
Q

Describe Proliferation phase: wound contraction

A
  • The surface and the cavity of the wound become smaller. Adjacent skin pulled closer to the center of the wound.
  • Especially loose skin
  • Begins 5-9 days after wounding
  • Stops when edges connected/tension
    too high
  • Risk of contracture
  • Thinning of the surrounding skin
    (temporary)
33
Q

Describe Proliferation phase: epithelialization

A
  • Proliferation of basal epithelial cells from the adjacent skin edges and their moving over and adhesion to the surface of the wound.
  • Prevention of excessive formation of granulation tissue.
  • Total duration can range from days to weeks.
  • Surface of the wound that has become epithelialized is known as the epithelial scar (thin and fragile).
34
Q

What is the maturation phase in regards to wound healing?

A

Maturation of tissue/the scar developed during the 3rd phase of wound healing, the proliferation phase (3rd part, epithelialization).

  • Increasing strength of the scar as a result of remodeling of tissue.
  • The newly formed collagen is arranged parallel to the tension lines of the skin.
  • Total duration can range from weeks to a year or even longer.
  • Usually have no or insufficient hair follicles, sweat and sebaceous glands, poor movability and elasticity and an absence of pigment.
  • The healed wound will never regain skin’s original strength.
35
Q

Acute vs chronic wounds

A

In chronic wounds there is a lack of orderly progression through the four phases of wound healing.

  • An important cause of chronic wounds is infection, which causes a sustained inflammatory phase.

Factors influencing wound healing:
* Malnutrition
* Radiation
* Use of corticosteroids
* Underlying metabolic diseases

36
Q

Differences between dogs and cats in wound healing:

A
  • Research predominantly in dogs
  • Intact skin of cats less perfused in comparison to dogs
  • Breaking strength of a wound 50% less in cats 7 days after primary closure
  • Formation of granulation tissue takes longer in cats and first appears only at the wound edges
  • Pseudohealing more common in cats (refers to what looks like a healed wound on the surface but in fact dehisces so it was not truly healed)
  • More research warranted
37
Q

Describe Wound management broadly.

A

Many will heal naturally. Some need intervention (large, necrotic, infected).

Management:
1) Stabilization of the patient!

1) Stopping the bleeding (pressure; special dressings for minor wounds [adrenaline-soaked gauze etc.])

2) Reduction of the level of contamination, clipping the area (ideally up to 4-6
hours after wounding to prevent bacterial infection).

38
Q

First 3 steps in wound management:

A

1) Stabilize the patient!

2) Stop active bleeding (pressure; special dressings for minor wounds
[adrenaline-soaked gauzes etc.])

3) Reduction of the level of contamination, clipping the area (ideally up to 4-6
hours after wounding to prevent bacterial infection).

39
Q

Identification of what is necessary
before initiating wound treatment?

A

Identification of the causative agent necessary before initiating treatment.

Exact trauma needn’t be known but at least Trauma vs. dermatologic disease (including
parasitosis) vs. neoplasia vs. ?

Important to treat the underlying cause in case of non-traumatic wounds.

40
Q

Describe wound irrigation (lavage)

A
  • Dirty or contaminated wounds can be cleaned by irrigation
  • Obvious debris, necrotic tissue, dirt and bacteria will be washed away by fluid under pressure
  • Irrigation pressure should not be too high because it may damage tissue and push contamination further into the wound
  • In Minimal to moderately contaminated wounds, cleaning is performed using isotonic saline or Ri-Lac
  • In selected patients, dilute antiseptic solutions such as 0.05% chlorhexidine or 1% povidone–iodine solution can be used.
41
Q

Describe wound debridement

A
  • In case of debris or necrotic tissue
  • Anesthesia often required
  • Objective is to convert the open contaminated wound into a surgically
    clean wound edge
  • Different methods (choice depends on the patient): surgical, mechanical, autolytic, enzymatic, chemical, biosurgical
  • More than one procedure may be necessary.
42
Q

Describe Surgical debridement

A
  • Used most commonly
  • Goal is to remove all obvious necrotic tissue and debris.
  • Difficult to distinguish necrotic nonviable tissue from healthy viable tissue during the inflammatory phase.
  • Layered approach often used (superficial tissues removed first).
  • Removal to the level where active bleeding is present.
  • Questionably viable tissue should be left in place and re-evaluated.
  • En-bloc debridement sometimes used (complete excision of the wound and all affected tissue).
43
Q

define En-bloc debridement

A

removing the entire wound, including its margins

En bloc debridement is used where there is adequate normal tissue present to allow closure after the debridement has occurred even when all the affected tissue has been excised.

” a block of tissue” versus layered removal approach

44
Q

Describe Mechanical debridement

A

a thin sliver of wound edge/surface may be removed

This can be Performed using wet-to-dry or dry-to-dry dressings after layered surgical debridement or as the sole means of debridement.

Wet-to-dry dressing (typically changed daily until granulation)
- Primary dressing of gauzes wetted with isotonic saline
- Several layers of wet gauze followed by several layers of dry gauze added
- As the bandage dries, it adheres to the wound surface
- Adhering tissue is removed as the dressing is changed

Dry-to-dry is the same procedure without wetting.

Several disadvantages; Some authors believe that these dressings no longer meet the expected standard of care in veterinary medicine.

45
Q

Describe Autolytic debridement

A
  • Creation of a moist wound environment to allow endogenous enzymes to dissolve nonviable tissue.
  • Often preferred in wounds with questionable tissue viability.
  • Highly selective for devitalized tissue
  • Can be performed with interactive dressings such as hydrogels, hydrocolloids, hydrofibers and foam dressings.
  • Use of honey or sugar topically (attraction of fluid).
  • Painless
  • Slow process
46
Q

Describe Enzymatic debridement

A
  • Proteolytic enzymes (exogenous) are applied to the wound to break down the necrotic tissue.
  • Wounds with small amounts of necrotic tissue or debris.
  • Trypsin, fibrinolysin, chymotrypsin, desoxyribonuclease, papain-urea
    and collagenase.
  • Sometimes used as an adjunct to mechanical and chemical wound
    debridement.
  • Effectiveness questionable
  • Slow process
47
Q

Name 6 types of wound debridement.

A

surgical (layered or en-bloc)
mechanical

autolytic
enzymatic

chemical
biosurgical (e.g. medical maggots)

48
Q

Describe Chemical debridement

A
  • Nonselective method (cells important for healing are also damaged)
  • Can be performed with antiseptics
  • Dakin’s solution, chlorhexidine, povidone-iodine, hydrogen peroxide
  • Not generally recommended
49
Q

Describe Biosurgical debridement

A
  • Placement of medical maggots (Lucilia sericata) into the wound.
  • The maggots produce enzymes that dissolve the necrotic tissue, but spare healthy tissue.
  • Maggots specially bred, expensive.
  • May be indicated for management of deep wounds.
50
Q

Describe Topical antibiotics and antiseptics

A
  • Systemic AB preferred (only for infected wounds)
  • The use of topical antibiotics and antiseptics is controversial – no
    beneficial effect once infection is established
  • Do not replace proper debridement
51
Q

Describe Topical wound medications such as antimicrobials and antibiotics.

A

Substances that may be used topically on wounds.

  • Triple antibiotic ointment
  • Silver sulfadiazine
  • Nitrofurazone
  • Gentamicin sulfate
  • Cefazolin
  • Mafenide
52
Q

Describe Topical wound “medications” such as Wound-healing enhancers.

A
  • Aloe vera
  • Tripeptide-copper complex
  • D-glucose polysaccharide
  • Honey
  • Sugar
  • Growth factors
  • Hydrolyzed bovine collagen
  • Chitosan
53
Q

Describe Open wound management

A
  • Due to wound characteristics/financial reasons/until surgical closure is possible
  • Superficial wounds
  • Dressing, bandage?
  • Wound-healing enhancers are used (such as honey)
  • Healing process often time-consuming
  • Might need some surgical intervention
54
Q

Describe Wound closure

A
  • Decision whether or not to close the wound, and when?
  • Primary closure
  • Delayed primary closure
  • Secondary closure
  • Drainage/drains
  • Tension lines (incisions/closure parallel to tension lines if possible)

Image depicts tension lines on illustrative dog.

55
Q

Describe primary wound closure.

A
  • Is preferred for clean wounds, including surgical wounds and contaminated wounds that have been debrided and are less than 6-8 hours old.
  • Direct closure of the wound after lavage and debridement.
  • Leads to a more rapid anatomical and functional recovery than delayed and secondary closure.
  • Sutures can generally be removed in 1-2 weeks.
  • If the level of contamination, tissue viability, depth of tissue damage or vascular supply is questionable, other options should be considered.
56
Q

Describe delayed primary wound closure.

A
  • Wound is managed as an open wound until it is clean and without formation of granulation tissue, then closed.

(if granulation tissue has time to form, so 5+days, then it is considered secondary closure).

  • Closure 3-5 days after the initial wounding.
  • Waiting Allows for drainage of the wound, a decrease in contamination and the development of a clear demarcation line between viable and necrotic tissue prior to surgery.
57
Q

Describe secondary wound closure.

A
  • Closure of the wound after the formation of granulation tissue (usually approx. 5 days after wounding).
  • Especially for contaminated or infected wounds.

Two methods:
* Leaving the existing granulation tissue intact, only separating the edge of the skin from the granulation tissue bed and advancing it over the wound.
or
* Excision of the granulation tissue bed followed by primary closure.

Second method is usually preferrable as:
* Wound edges more mobile
* Incidence of infection lower
* Cosmetic reasons

58
Q

Name 3 main wound closure options:

A

primary
delayed primary
secondary

59
Q

Describe wound drainage.

A

Necessary at times (moderate contamination or a large dead space).

The dead space resulting from suturing of large wounds promotes fluid accumulation, which is a good medium for growth of bacteria.

Passive drains (Penrose drain) are:
* Easier to insert, cost less
* Draining under gravity
* Risk of ascending infection

Active drains
* Creation of a vacuum that removes fluid by suction
* Can be placed anywhere on the body
* Containers need to be emptied regularly

Drain Removal as soon as possible (usually 2-4 days).

60
Q

what’s this

A

pen rose drain or passive drain

  • Easier to insert, cost less
  • Draining under gravity
  • Risk of ascending infection
61
Q

what’s this

A

active drains

  • Creation of a vacuum that removes fluid by suction
  • Can be placed anywhere on the body
  • Containers need to be emptied regularly
  • e.g. Jackson Pratt drain
62
Q

Wound dressings and bandages: difference.

A

Dressing materials are applied directly to the surface of a wound. It’s most important function is to allow moist healing.

No single dressing perfect for all wounds in all phases of wound healing – initial and follow-up assessments are necessary.

Bandage wraps are to hold plain and medicated dressings in place
(immobilization, pressure to control hemorrhage, obliteration of dead
space, protection from external trauma and contamination).

  • Primary layer (contact dressing)
  • Secondary (absorptive) layer
  • Tertiary (protective) layer
63
Q

Bandaging can be divided into 3 layers:

A
  • Primary layer (contact dressing against actual wound)
  • Secondary (absorptive for exudates) layer
  • Tertiary (protective) layer
64
Q

Functions of wound dressings.

A
  • Provide a moist environment
  • Provide a warm environment
  • Protect from trauma
  • Protect from external contamination
  • Application of topical medication
  • Immobilization of the wound
  • Support of the wound edges
  • Absorb exudate
  • Prevent or reduce edema
  • Provide an aesthetic appearance
65
Q

Describe wound bandages in general.

A
  • Appropriate materials of adequate width should be used.
  • As smoothly as possible to prevent irritation and skin necrosis.
  • Each turn of the bandage should overlap the previous turn by 50%.
  • Patients should be observed for discomfort, swelling, appendage hypothermia, skin discoloration, dryness, or odor.
  • (absorbent, adherent, non-adherent, stabilizing, pressure bandages, pressure relief bandages etc.)
66
Q

Describe/name Advanced techniques used in wound care/healing.

A

Used for chronic wounds.

  • Topical negative pressure
  • Low-level laser therapy
  • Hyperbaric oxygen therapy
  • Ultrasound

Seldom used, research warranted.

67
Q

Recite the Protocol for wound management. (10 steps)

A
  1. Use a clean room and aseptic technique.
  2. Obtain a complete medical history of the patient.
  3. Obtain information about the cause and age of the wound.
  4. Make a complete assessment of the wound.
  5. Debride necrotic tissue.
  6. Remove contamination.
  7. Choose the appropriate method of closure.
  8. Choose the appropriate dressing.
  9. Make regular assessments to monitor the progression of wound healing.
  10. When dealing with chronic wounds not responding to normal wound management, consider using an advanced technique.
68
Q

Describe surgical closure of wounds.

A
  • Possibilities limited mostly by imagination
  • Note tension (‘’dog ears“)
  • Skin stretching and expansion