Wound Healing Flashcards
Wound healing occurs in non-overlapping phases: Inflammatory
Proliferative
Remodeling
F
Overlapping. Phase order is correct.
sometimes haemostasis added as the first stage to make 4 stages
The depth of the wound determines the degree of contraction and the source of keratinocytes used for re-epithelialisation.
T
Sharp wounds created by scalpels heal faster than wounds created by destructive or ablative methods.
T
Platelets are the first cell to appear in the healing process.
T
Macrophages are the most important cell in the healing process.
T
Older patients tend to heal faster.
F
Slower.
Patient age is a critical factor in wound healing
Older patients’ wounds tend to have less tensile strength which correlates with reduced amounts of collagen and a worse cosmetic outcome.
F
Better cosmetic outcome. Everything else is true.
An erosion is defined as a wound that involves structures deep to the dermis.
F
This is true for an ulcer. Erosion = wound with only epidermal loss.
A partial-thickness wound is an ulcer that involves the epidermis and varying parts of the dermis.
T
A full-thickness wound is one that involves all of the dermis and deeper structures.
T
In partial-thickness wounds, skin appendages remain and serve as reservoirs of epithelial cells to repopulate the epidermis.
T
Partial-thickness wounds heal to some extent by contraction, while there is minimal contraction in full-thickness wounds.
F
Other way around.
Second intention healing refers to the process by which an acute wound heals on its own.
T
Occurs primarily by contraction of myofibroblasts.
Primary intention healing occurs when a surgeon directs closure of the wound by approximating the wound edges.
T
The method by which a wound was created does not tend to influence its healing.
F Wounds created by sharp steel (eg. surgery) heal faster than others.
The process of wound haemostasis can be divided into two parts – development of a fibrin clot and coagulation.
T
Almost immediately after injury, polymorphonuclear leukocytes begin to adhere to the sticky endothelium of venules.
T
The term margination refers to the process by which the entire endothelial margin of the venules may be covered with neutrophils.
T
In the early inflammatory state, macrophages predominate at the site of injury.
F
Neutrophils and monocytes. Macrophages later.
As inflammation persists the number of neutrophils increases although macrophages predominate
F
Neutrophils decrease
The presence of wound contamination prolongs the neutrophilic presence within the wound.
T
Neutrophils release elastase and collagenase
T
Macrophages phagocytise, digest and kill pathogenic organisms, scavenge tissue debris and destroy remaining neutrophils
T
Macrophages tolerate severe hypoxia well.
T
The presence of macrophages may act to reduce collagen deposition
F
May enhance it
Macrophages are essential for production of growth factors – they synthesize and secrete PDGF, fibroblast growth factor, vascular endothelial growth factor, TGF beta and TGF alpha
T
Mast calls help regular haemostasis by releasing substances such as platelet activiating factor, heparin, tryptase, chymase and t-plasminogen activator
T
The proliferation phase of wound healing involves re-epithelialisation (the creation of a permeability barrier), angiogenesis (the establishment of an appropriate blood supply) and fibroplasia (the reinforcement of injured tissue).
T
