Wound Healing Flashcards
intermediate phase: when and what (3)
4-30 days
epithelialization (24-48h after for incisional wounds)
angiogenesis
fibroblast migration & proliferation
early phase? how many days?
0-5 days
inflammatory. PMNs migrate to area first 48-72h
macrophages migrate 72h after injury, stimulate fibroblasts & collagen production
when is the late phase and what is it (4)
3 weeks- 2 years
matrix deposition for collagen
collagen synthesis
thickening of collagen fibers- increased tensile strength
wound contraction (continues for 12-15 days)
collagen synthesis timeline
begins 3-5 days after injury
rapid rate up to 4-5 weeks, then declines
when does the collagen content peak in a healing wound
4 weeks
when does the wound reach 80% of eventual strength? 90%?
6 weeks
6 mo.
when and what is the final phase of wound healing
30 days - 2 years
scar remodeling & maturation
becomes avascular and acellular
most common method of wound closure?
primary intention
how does a wound close by secondary intention
contraction & epithelialization
which wounds are usually closed by secondary intention? (3)
full thickness wounds
contaminated
infected
which wounds are closed by tertiary intention
obvious infection or contamination
how do you close an abrasion
rarely closed
closing a puncture?
secondary intention
closing a laceration?
6-8h after wound or ASAP
how long to leave a dressing in place on a clean wound
48h