wound healing 2

Question 1

healing by first intention involves what?

Answer 1

Focal disruption of epithelial basement membrane
relatively little cell death
small scar, minimal wound contraction
surgical incision

Question 2

healing by second intention

Answer 2

more extensive cell loss and wound contraction

Question 3

Healing by first intention - 24 hours

1) What forms?
2) what happens underneath answer to 1) and why

Answer 3

1) Thrombosis (Scab) which acts as a barrier to invading organisms and prevents loss of tissue fluid
2) inflammation so neutrophils and exudation

Question 4

healing by first intention - 3 to 7 days

1) what occurs
2) what forms
3) neutrophils from 24 hours are replaced by what?
4) what layer forms above the answer from 3)

Answer 4

1) regeneration, labile epithelial cells migrate and proliferate
2) form a thin epithelial layer beneath the scab
3) macrophages so there are mediators that help repair
4) granulation tissue, so angiogensis, fibroblast recuirtment and activation and forms new stroma.

Question 5

Scar formation

1) accumulation of what collagen?
2) what cell infiltrates and so what decreases?
3) what else decrease
4) wound strength

Answer 5

1) type 1
2) leukocyte infiltrate and edema decrease
3) vascularity
4) wound strength increases

Question 6

Healing by second intention

1) size of clot?
2) more of what 2 things?
3) wound size
4) what type of fibroblast

Answer 6

1) larger clot
2) more granulation and inflammation
3) wound contraction so reduce the size of the wound
4) myofibroblasts, modified fibroblast with smooth muscle cell like properties

Question 7

wound dehiscence is?

Answer 7

splitting due to infection,inappropriate suturing, poor nutrition and mechanical forces